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Feb 27, 2024

Biomarker Changes during 20 Years Preceding Alzheimer’s Disease

Posted by in categories: biotech/medical, chemistry, life extension, neuroscience

We conducted a multicenter, nested case–control study of Alzheimer’s disease biomarkers in cognitively normal participants who were enrolled in the China Cognition and Aging Study from January 2000 through December 2020. A subgroup of these participants underwent testing of cerebrospinal fluid (CSF), cognitive assessments, and brain imaging at 2-year–to–3-year intervals. A total of 648 participants in whom Alzheimer’s disease developed were matched with 648 participants who had normal cognition, and the temporal trajectories of CSF biochemical marker concentrations, cognitive testing, and imaging were analyzed in the two groups.

The median follow-up was 19.9 years (interquartile range, 19.5 to 20.2). CSF and imaging biomarkers in the Alzheimer’s disease group diverged from those in the cognitively normal group at the following estimated number of years before diagnosis: amyloid-beta (Aβ)42, 18 years; the ratio of Aβ42 to Aβ40, 14 years; phosphorylated tau 181, 11 years; total tau, 10 years; neurofilament light chain, 9 years; hippocampal volume, 8 years; and cognitive decline, 6 years. As cognitive impairment progressed, the changes in CSF biomarker levels in the Alzheimer’s disease group initially accelerated and then slowed.

In this study involving Chinese participants during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease, we observed the time courses of CSF biomarkers, the times before diagnosis at which they diverged from the biomarkers from a matched group of participants who remained cognitively normal, and the temporal order in which the biomarkers became abnormal. (Funded by the Key Project of the National Natural Science Foundation of China and others; number, NCT03653156. opens in new tab.)

Feb 27, 2024

College to offer free medical degrees after $1bn gift

Posted by in categories: biotech/medical, education

“A New York City medical school will offer students free tuition following a $1bn donation from the 93-year-old widow of a major Wall Street investor.”

The record-breaking donation came from a 93-year-old former professor, who is the widow of a wealthy investor.

Feb 27, 2024

Super-realistic prosthetic eyes made in record time with 3D printing

Posted by in categories: 3D printing, biotech/medical, cyborgs

Scientists can now 3D print more-realistic prosthetic eyes in a fraction of the time and effort required by traditional approaches.

Feb 27, 2024

Texas Tech System receives 6,000 acres in state’s “Big Empty” region for research, learning labs

Posted by in category: food

The property is currently an observatory surrounded by open land. System officials say they’ll use it for agricultural research and other opportunities.

Feb 27, 2024

3 new moons discovered around Uranus and Neptune will be named after Shakespeare characters and Greek goddesses

Posted by in category: space

The International Astronomical Union has confirmed the existence of three currently unnamed moons — one around Uranus and two orbiting Neptune.

Feb 27, 2024

‘Fail quickly and inexpensively’: Nvidia founder and CEO Jensen Huang shares his mantra for success — here’s why Jim Cramer calls him a bigger visionary than Elon Musk

Posted by in category: Elon Musk

Important lessons from the Big Tech CEO of the hour.

Feb 27, 2024

Enhancing Lunar Exploration: Realistic Simulation of Moon Dust for Robot Operation

Posted by in categories: robotics/AI, space

Joe Louca: “Think of it like a realistic video game set on the Moon – we want to make sure the virtual version of moon dust behaves just like the actual thing, so that if we are using it to control a robot on the Moon, then it will behave as we expect.”

After Neil Armstrong took his first steps on the Moon, he said, “It’s almost like a powder”, as he described the lunar regolith, and astronauts on future Apollo missions found working on the lunar surface rather cumbersome and tedious due to the much finer lunar dust compared to Earth’s dirt. Therefore, what steps can be taken to better prepare future rovers and astronauts for NASA’s Artemis program to work on the lunar surface?

This is what a recent study published in Frontiers in Space Technologies hopes to address as a team of researchers led by the University of Bristol developed virtual models of lunar regolith simulants that could provide cost-effective methods to prepare astronauts and robots to work on the lunar surface, someday.

Continue reading “Enhancing Lunar Exploration: Realistic Simulation of Moon Dust for Robot Operation” »

Feb 27, 2024

Do Large Language Models Latently Perform Multi-Hop Reasoning?

Posted by in category: futurism

Join the discussion on this paper page.

Feb 27, 2024

Oppo’s AR glasses really look like regular glasses

Posted by in category: augmented reality

Like Google Glass, but…better?

Feb 27, 2024

Exploring galaxy groups and clusters and their brightest galaxies within the cosmic web

Posted by in category: cosmology

A common belief among astronomers is that galaxy groups and clusters differ mainly in the number of galaxies they contain—there are fewer galaxies in groups and more in clusters. Led by Maret Einasto, astronomers at Tartu Observatory of the University of Tartu decided to look into that and discovered even more differences between groups and clusters.

The structure of the universe can be described as a giant network, a cosmic web, with chains (filaments) of single galaxies and small groups of galaxies connecting rich and clusters that can contain thousands of galaxies. Between galaxy systems, there are giant voids with almost no visible matter (galaxies and gas). Galaxy groups and clusters can, in turn, form even larger systems called superclusters.

In their study, Tartu astronomers used data on galaxy groups, their brightest galaxies (so-called main galaxies), and their surroundings. The aim was to combine these data to see whether it could provide new information about the possible classification of groups of different sizes.

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