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Gene-editing nanoparticle system targets multiple organs simultaneously

A gene-editing delivery system developed by UT Southwestern Medical Center researchers simultaneously targeted the liver and lungs of a preclinical model of a rare genetic disease known as alpha-1 antitrypsin deficiency (AATD), significantly improving symptoms for months after a single treatment, a new study shows. The findings, published in Nature Biotechnology, could lead to new therapies for a variety of genetic diseases that affect multiple organs.

“Multi-organ diseases may need to be treated in more than one place. The development of multi-organ-targeted therapeutics opens the door to realizing those opportunities for this and other diseases,” said study leader Daniel Siegwart, Ph.D., Professor of Biomedical Engineering, Biochemistry, and in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern.

Gene editing—a group of technologies designed to correct disease-causing mutations in the genome—has the potential to revolutionize medicine, Dr. Siegwart explained. Targeting these technologies to specific organs, tissues, or will be necessary to effectively and safely treat patients.

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Artificial neural networks reveal how peripersonal neurons represent the space around the body

The brains of humans and other primates are known to execute various sophisticated functions, one of which is the representation of the space immediately surrounding the body. This area, also sometimes referred to as “peripersonal space,” is where most interactions between people and their surrounding environment typically take place.

Researchers at Chinese Academy of Sciences, Italian Institute of Technology (IIT) and other institutes recently investigated the neural processes through which the brain represents the area around the body, using brain-inspired computational models. Their findings, published in Nature Neuroscience, suggest that receptive fields surrounding different parts of the body contribute to building a modular model of the space immediately surrounding a person or (AI) agent.

“Our journey into this field began truly serendipitously, during unfunded experiments done purely out of curiosity,” Giandomenico Iannetti, senior author of the paper, told Medical Xpress. “We discovered that the hand-blink reflex, which is evoked by electrically shocking the hand, was strongly modulated by the position of the hand with respect to the eye.

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Herpes virus reshapes the human genome for its own benefit, but a single enzyme can stop it

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the host’s cellular machinery to make new copies of themselves. Herpes simplex virus-1 (HSV-1), it turns out, also redecorates, according to a study in Nature Communications.

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have discovered the cold sore reshapes the human genome’s architecture, rearranging its shape in three-dimensional space so that HSV-1 can access host genes most useful for its ability to reproduce.

“HSV-1 is an opportunistic interior designer, reshaping the human genome with great precision and choosing which bits it comes into contact with. It’s a novel mechanism of manipulation we didn’t know the virus had to exploit host resources,” says Dr. Esther González Almela, first author of the study.

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‘The models were right’: Astronomers find ‘missing’ matter linking four galaxy clusters

Astronomers have discovered a huge filament of hot gas bridging four galaxy clusters. At 10 times as massive as our galaxy, the thread could contain some of the universe’s ‘missing’ matter, addressing a decades-long mystery.

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Passive cooling paint sweats off heat to deliver 10X cooling and 30% energy savings

A new cement-based paint can cool down the building by sweating off the heat. The cooling paint, named CCP-30, was designed by an international team of researchers and features a nanoparticle-modified porous structure composed of a calcium silicate hydrate (C-S-H) gel network.

This design enabled it to achieve superior cooling by combining both radiative, evaporative and reflective cooling mechanisms, which allowed it to reflect 88–92% of sunlight, emit 95% of the heat as , and hold about 30% of its weight in water, making it a paint ideal for keeping spaces cool throughout the day and across seasons.

As per the findings published in Science, the paint provides 10 times the cooling power of commercial cooling paints in tropical climates, resulting in electricity savings of 30 to 40%.

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Websites are tracking you via browser fingerprinting, researchers show

Clearing your cookies is not enough to protect your privacy online. New research led by Texas A&M University has found that websites are covertly using browser fingerprinting—a method to uniquely identify a web browser—to track people across browser sessions and sites.

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Electron microscopy technique captures nanoparticle organizations to forge new materials

A research team including members from the University of Michigan have unveiled a new observational technique that’s sensitive to the dynamics of the intrinsic quantum jiggles of materials, or phonons.

This work will help scientists and engineers better design metamaterials—substances that possess exotic properties that rarely exist in nature—that are reconfigurable and made from solutions containing nanoparticles that self-assemble into larger structures, the researchers said. These materials have wide-ranging applications, from shock absorption to devices that guide acoustic and optical energy in high-powered computer applications.

“This opens a new research area where nanoscale building blocks—along with their intrinsic optical, electromagnetic and —can be incorporated into mechanical metamaterials, enabling emerging technologies in multiple fields from robotics and mechanical engineering to information technology,” said Xiaoming Mao, U-M professor of physics and co-author of the new study.

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Researcher’s lifelong work sheds light on neurodegenerative diseases caused by errors in cellular protein production

One of the great biological mysteries of the human body is how hundreds of complex, origami-like proteins, many of which are crucial for normal body function, come to assume their final, correct shape.

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Improved thermoelectrics: Scientists harness ‘traffic jam of electrons’ to boost heat-to-electricity conversion

Electricity can be easily converted into heat—every electric cooker does it. But is the opposite also possible? Can heat be converted into electricity—directly, without a steam turbine or similar detours?

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