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Blog – Page 17

Breakthrough light-powered chip speeds up AI training and reduces energy consumption.

Engineers at Penn have developed the first programmable chip capable of training nonlinear neural networks using light—a major breakthrough that could significantly accelerate AI training, lower energy consumption, and potentially lead to fully light-powered computing systems.

Unlike conventional AI chips that rely on electricity, this new chip is photonic, meaning it performs calculations using beams of light. Published in Nature Photonics.

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The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed cell death, is also necessary for the proper development and function of the body. It has also been a focus of researchers developing treatments for cancer by finding ways to activate the cell death of cancer cells themselves.

Ferroptosis is a recently discovered form of programmed and has been a promising target for the development of cancer treatments. It is mediated by iron molecules, with the cell dying through the degradation of the phospholipid bilayer by oxidation, a process called . However, recent studies have shown that certain cancer cells are less susceptible to ferroptosis, raising concerns that this resistance could pose a barrier to future therapeutics.

In a paper published in Nature Communications, researchers from Kyushu University, using cultured cells and mice, found that the lipid peroxidation of the lysosomes—the organelle responsible for degrading and recycling molecules in a cell—plays a critical role in the execution of ferroptosis.

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Antimicrobial resistance (AMR) presents a serious challenge in today’s world. The use of antimicrobials (AMU) significantly contributes to the emergence and spread of resistant bacteria. Companion animals gain recognition as potential reservoirs and vectors for transmitting resistant microorganisms to both humans and other animals. The full extent of this transmission remains unclear, which is particularly concerning given the substantial and growing number of households with companion animals. This situation highlights critical knowledge gaps in our understanding of risk factors and transmission pathways for AMR transfer between companion animals and humans. Moreover, there’s a significant lack of information regarding AMU in everyday veterinary practices for companion animals.

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Antimicrobial resistance (AMR) presents a serious challenge in today’s world. The use of antimicrobials (AMU) significantly contributes to the emergence and spread of resistant bacteria. Companion animals gain recognition as potential reservoirs and vectors for transmitting resistant microorganisms to both humans and other animals. The full extent of this transmission remains unclear, which is particularly concerning given the substantial and growing number of households with companion animals. This situation highlights critical knowledge gaps in our understanding of risk factors and transmission pathways for AMR transfer between companion animals and humans. Moreover, there’s a significant lack of information regarding AMU in everyday veterinary practices for companion animals. The exploration and development of alternative therapeutic approaches to antimicrobial treatments of companion animals also represents a research priority. To address these pressing issues, this Reprint aims to compile and disseminate crucial additional knowledge. It serves as a platform for relevant research studies and reviews, shedding light on the complex interplay between AMU, AMR, and the role of companion animals in this global health challenge. This Reprint is especially addressed to companion animal veterinary practitioners as well as all researchers working on the field of AMR in both animals and humans, from a One Health perspective.

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Neutrophils, one of the immune system warriors that were thought to be all the same, turn out to be diverse. Unfortunately, these cells are also active in autoimmune diseases. New research has found that a certain subpopulation of these white blood cells can predict disease relapse at an early stage, which may enable improved personalized treatment.

In a study published in Nature Communications, a multi-institutional research team investigated which cell types dominate the blood of patients at the early stage of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, which is caused by inflammation in the blood vessels and can disrupt organ function.

“Figuring out the mechanism of this disease, which is poorly understood, will help us understand autoimmune dysregulation in neutrophils. This could aid in the development of new drugs tailored for each patient,” says the lead author of the study. “Because we want to understand the dynamics of neutrophil behavior at the cell level in the early stages of the disease, for this study we recruited new patients that had not yet been treated.”

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Is the nearest galaxy to ours being torn apart? Research suggests so. A team led by Satoya Nakano and Kengo Tachihara at Nagoya University in Japan has revealed new insights into the motion of massive stars in the Small Magellanic Cloud (SMC), a small galaxy neighboring the Milky Way. Their findings suggest that the gravitational pull of the Large Magellanic Cloud (LMC), the SMC’s larger companion, may be tearing the smaller one apart. This discovery reveals a new pattern in the motion of these stars that could transform our understanding of galaxy evolution and interactions. The results were published in The Astrophysical Journal Supplement Series.

“When we first got this result, we suspected that there might be an error in our method of analysis,” Tachihara said. “However, upon closer examination, the results are indisputable, and we were surprised.”

The SMC remains one of the closest galaxies to the Milky Way. This proximity allowed the research team to identify and track approximately 7,000 massive stars within the galaxy. These stars, which are over eight times the mass of our Sun, typically survive for only a few million years before exploding as supernovae. Their presence indicates regions rich in hydrogen gas, a crucial component of star formation.

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Urea, with the formula CO(NH2)2, is a chemical compound that is widely used in a range of sectors, including manufacturing, agriculture and various industries. Conventionally, this compound is produced via a two-step process that entails the synthesis of ammonia from nitrogen (N₂) and its subsequent reaction with carbon dioxide (CO₂).

This reaction occurs at and under , leading to the formation of a compound called ammonium carbamate. This compound is then decomposed at lower pressures, which ultimately produces and water.

Traditional processes for producing urea are very energy intensive, meaning that to produce desired amounts of urea they consume a lot of electrical power. Over the past few years, some engineers have thus been trying to devise more energy-efficient strategies to synthesize urea.

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