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A new approach to combating asthma-induced bronchial remodeling

Patients with bronchial asthma suffer from attacks of shortness of breath caused by constricted airways. “Anti-inflammatory medications are usually given to treat this, although it isn’t quite clear how inflammation and constriction correlate,” says Professor Daniela Wenzel, head of the Department of Systems Physiology in the Faculty of Medicine at Ruhr University Bochum.

“These medications often stop working at a certain point.” Furthermore, often experience a thickening of the bronchial tissue due to the accumulation of collagen. Goblet cells also form in increasing numbers, producing mucus and making breathing even more difficult. Currently, there is no medication to counteract these changes.

Cost effective method developed for co-packaging photonic and electronic chips

The future of digital computing and communications will involve both electronics—manipulating data with electricity—and photonics, or doing the same with light. Together the two could allow exponentially more data traffic across the globe in a process that is also more energy efficient.

“The bottom line is that integrating photonics with electronics in the same package is the transistor for the 21st century. If we can’t figure out how to do that, then we’re not going to be able to scale forward,” says Lionel Kimerling, the Thomas Lord Professor of Materials Science and Engineering at MIT and director of the MIT Microphotonics Center.

Enter FUTUR-IC, a new research team based at MIT. “Our goal is to build a microchip industry value chain that is resource-efficient,” says Anu Agarwal, head of FUTUR-IC and a principal research scientist at the Materials Research Laboratory (MRL).

Before These Clouds Form Stars, They Form A Complex Network of Filaments

Researchers working with China’s Five-hundred-meter Aperture Spherical radio Telescope (FAST) have revealed some of the complexity in a type of cloud in the ISM. They’ve detected a network of filaments in one Very High Velocity Cloud (VHVC). The observations hint at the complexity that can evolve in these clouds, all without the influence of gravity.

Lunar soil could support life on the Moon, say scientists

Scientists have developed a technology that may help humans survive on the moon. In a study published in the journal Joule, researchers extracted water from lunar soil and used it to convert carbon dioxide into oxygen and chemicals for fuel—potentially opening new doors for future deep space exploration by mitigating the need to transport essential resources like water and fuel all the way from Earth.

“We never fully imagined the ‘magic’ that the lunar soil possessed,” said Lu Wang of the Chinese University of Hong Kong, Shenzhen.

“The biggest surprise for us was the tangible success of this integrated approach. The one-step integration of lunar H2O extraction and photothermal CO2 catalysis could enhance energy utilization efficiency and decrease the cost and complexity of infrastructure development.”

Groundbreaking Study Identifies Four Biologically Distinct Autism Subtypes

Autism reveals multiple biological subtypes, each with unique genetic and developmental patterns. Researchers from Princeton University and the Simons Foundation have discovered four autism subtypes that are both clinically and biologically distinct. This breakthrough offers a deeper understandin

Kinase enzymes exist throughout tree of life—those found in bacteria may be vulnerable targets for new antibiotics

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have developed an atlas of bacterial kinases and say their new compendium holds a motherlode of possible targets for reimagined antimicrobial drugs.

A team of researchers at the University of Georgia has zeroed in on serine-threonine , regulators of cell growth and pathogenicity in a multitude of bacterial species. They say their compendium can provide guidance on research into bacterial virulence and potentially trailblazing ways to attack bacteria by inhibiting the activity of serine-threonine kinases. The team’s compendium was developed by analyzing serine-threonine kinases in nearly 26,000 strains of bacteria.

“Bacterial serine-threonine kinases regulate diverse cellular processes associated with , virulence, and pathogenicity and are evolutionarily related to the druggable eukaryotic serine-threonine kinases,” writes researcher Dr. Brady O’Boyle of the University of Georgia, lead author of the new study involving the massive atlas. O’Boyle and his team found that the number of serine-threonine kinases within bacterial genomes ranges from 1 in Escherichia coli to more than 60 in some species of Actinobacteria.