Lifeboat Foundation

The incidence of cancer increases exponentially as we age. Unlike most age-related diseases, which generally cause cell and tissue degeneration and loss of function, cancer cells must acquire different, albeit aberrant, functions to progress to lethal disease. One link between age-related cancer and degeneration could be an inflammatory tissue environment driven by MTOR in senescent cells.

In her groundbreaking 2010 research perspective paper, The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression, Dr. Judith Campisi from the Buck Institute for Research on Aging highlighted the tumor-promoting aspects of senescent cells. Campisi’s research showcased the significant ability of senescent cells to reshape the cellular landscape around them, crafting what scientists term the ‘microenvironment.’

Far from being an inert backdrop, this microenvironment serves as a dynamic stage upon which cells interact and potentially pave the way for disease progression, particularly cancer.

This may be a great idea. Currently watching. Several countries are trying this.

The race is on to build the world’s first floating city.
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The recent surge in generative artificial intelligence (AI) technology is boosting the tech industry after growth slowed across the sector earlier this year.

As federal interest rates rose and the tech industry was coming off a pandemic-induced high, the once-vibrant sector suffered through lower earnings and layoffs throughout the year.

Britain’s state-run national health service will be the first in the world to offer an injection that treats cancer to hundreds of patients in England which could cut treatment times by up to three quarters.

Following approval from the Medicines and Healthcare products Regulatory Agency (MHRA), NHS England said on Tuesday (Aug 29) hundreds of eligible patients treated with the immunotherapy, atezolizumab, were set to have “under the skin” injection, which will free up more time for cancer teams.

“This approval will not only allow us to deliver convenient and faster care for our patients, but will enable our teams to treat more patients throughout the day,” Dr Alexander Martin, a consultant oncologist at West Suffolk NHS Foundation Trust said.

In a discovery akin to a sci-fi novel, scientists have observed the formation of reality-bending structures known as Alice Rings in a super-cold gas. These peculiar circular formations, named after Lewis Carroll’s iconic Alice of Wonderland fame, have given physicists an unprecedented opportunity to study one-sided magnetism.

Scientists have recently reviewed the available literature to examine the critical roles played by mitochondria in maintaining homeostasis. The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases. This review has been published in Experimental & Molecular Medicine.

Mitochondria is a cytoplasmic organelle in most eukaryotic cells and is enclosed by two phospholipid membranes: the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM). These membranes separate functionally compartmentalized structures, i.e., matrix and intermembrane space. Mitochondria contain a unique genetic code, mitochondrial DNA (mtDNA).

During evolution, most mitochondrial genes were lost or translocated to nuclei. However, genes that remained in mtDNA encode for essential translational apparatus, i.e., ribosomal RNAs and transfer RNAs. In addition, these genes also encode proteins that are key components of oxidative phosphorylation system (OXPHOS) complexes embedded in the IMM.

The James Webb Space Telescope has revealed colorful new portraits of the iconic Ring Nebula that capture unprecedented details a dying star creates glowing structures.

The findings suggest that adenosine base editing raised the expression of fetal hemoglobin to higher, more stable, and more uniform levels than other genome editing technologies that use CRISPR/Cas9 nuclease in human hematopoietic stem cells.

“Ultimately, we showed that not all genetic approaches are equal,” said Jonathan Yen, PhD, genome engineering group director at St. Jude Children’s Research Hospital. “Base editors may be able to create more potent and precise edits than other technologies. But we must do more safety testing and optimization.”

SCD and beta-thalassemia are blood disorders caused by mutations in the gene encoding hemoglobin affecting millions of people. Restoring gene expression of an alternative hemoglobin subunit active in a developing fetus has previously shown therapeutic benefit in SCD and beta-thalassemia patients. The researchers wanted to find and optimize genomic technology to edit the fetal hemoglobin gene.

Continue reading “Base Editing Beats Other Genome Editing Strategies for Treating Sickle Cell Disease” »

Now, you can use Google’s AI to make spreadsheets, whip up slide decks, and summarize all those documents you were never going to actually read.

Google announced today that it is rolling out its Duet AI assistant across all of its Workspace apps, including Gmail, Drive, Slides, Docs, and more. The Duet tech has been in testing for a while, the company said, with more than a million people already kicking the tires on Google’s virtual assistant. Now, it’s coming to anyone paying for Google’s Workspace apps.

Google announced Duet AI at its I/O developer conference earlier this year, pitching the collection of features as a helpful collaborator in all your Google apps. You might ask Duet to turn… More.

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