Lifeboat Foundation

A team of scientists at the City of Hope Hospital – one of the largest cancer research and treatment organizations in the United States – has recently developed what could potentially be a “holy grail” molecule that can effectively eradicate all solid cancer tumors while leaving healthy cells unaffected.

In preclinical trials, this molecule – called AOH1996 – was found to target and eradicate the proliferating cell nuclear antigen (PCNA) protein, which usually contributes to the growth and repair of a variety of cancer tumors.

Most of the previous targeted anti-cancer therapies focus on a single pathway, enabling cancers to mutate and eventually become resistant. By contrast, since AOH1996 targets a cancerous variant of PCNA, a protein that in its mutated form is crucial in DNA replication and repair of all types of tumors, its effectiveness is higher and its range of action significantly broader.

Plants possess the unique ability to completely regenerate from a somatic cell, i.e., an ordinary cell that does not typically participate in reproduction. This process involves the de novo (or new) formation of a shoot apical meristem (SAM) that gives rise to lateral organs, which are key for the plant’s reconstruction.

On a cellular scale, the formation of SAM is meticulously controlled by either positive or negative regulators (genes/protein molecules) that may induce or restrict shoot regeneration, respectively. But which molecules are involved? Are there other regulatory layers that are yet to be uncovered?

To seek answers to the above questions, a research group led by Nara Institute of Science and Technology (NAIST), Japan studied the process in Arabidopsis, a plant commonly used in genetic research.

In this article, the fourth installment of our five-part series on different pathways of aging, we look at the rejuvenation of cells, tissues, and stem cells, a topic that has been gaining increasing popularity thanks to remarkable advancements in the field of epigenetic reprogramming. Recent research suggests that despite the accumulation of molecular damage over time, cells and tissues can indeed undergo rejuvenation. We’ll be exploring key subjects such as Epigenetic reprogramming, PGC1a and GSK3β, Telomerase (TERT), as well as Apoptosis and senescence. Join us on this enlightening journey as we uncover the groundbreaking discoveries that are shaping the future of aging research.

The idea for reprogramming was simple yet beautiful. Children are born young, even though their parents are old, because they have undergone a process of cellular reprogramming that leads to rejuvenation.

NASA Commercial Space Capabilities office and SpaceX have a 24 page agreed plan to develop the SpaceX starship into a low earth orbit space station design by 2028. This is unfunded and aspirational. The parties will cooperate to try and make it happen. SpaceX with successful Starlink commercial services will have the funds to make this happen.

There are many other milestones that NASA and SpaceX are trying to achieve with Starship.

It will take another 2–4 years to actually launch the Starship space station.

Radiation therapy is a key component of care for many types of cancers. But some tumors can be more difficult than others to treat. Cancers in the lungs, for example, move with each breath, while tumors that have metastasized to many places in the body can require repeated radiation sessions.

Earlier this week, Stanford Medicine launched a new method of delivering radiation that uses signals from cancer-targeting molecules called tracers to target tumors in real time. It is the first time the new approach, known as biology-guided radiation therapy or SCINTIX^TM, has been used in a clinic.

Continue reading “Stanford Medicine first to try out novel tumor-targeting radiation therapy machine” »

A paper published in GeroScience has described a gene responsible for a key biomarker of cellular senescence.

However, SA-ß-gal’s actual relationship to senescence processes has not been fully explored. In order to explore its potential as a biomarker, these researchers developed an RNA-binding protein that restricts SA-ß-gal expression both in C.elegans worms and in human cell cultures, and their experiments provided some insights into how this compound works.

Woa, 😲, my Wave after Wave of AI controlled fighter aircraft idea. If you like that one you will love my mini UAV idea, i dont know if Ion drive or electric centrifuge weapons are up to it yet though, maybe.

The Times, citing congressional expectations, reported that the costs of the Air Force’s collaborative combat aircraft will be between $3 million and $25 million depending on their status as expendable, attritable, or exquisite. Even the higher-end figure is far less than a manned aircraft with a pilot, both of which are valuable to the force.

Air Force and Department of Defense representatives did not immediately respond to Insider’s request for comment. Kratos Defense, which makes the Valkyrie, would not comment on collaborative combat aircraft, citing the classified nature of the program.

Continue reading “The US Air Force wants $5.8 billion to build 1,000 AI-driven unmanned combat aircraft, possibly more, as part of its next generation air dominance initiative” »

An artificial intelligence algorithm defeated a human F-16 fighter pilot in a virtual dogfight sponsored by DARPA Thursday.

Aditya-L1 will carry out scientific studies of the Sun from a vantage point 1.5 million km above Earth.