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Blog – Page 1709

Alpha ketoglutarate, or AKG, has long been used as a dietary supplement in the bodybuilding world.

By satisfying bioenergetic demands, generating biomass, and providing metabolites serving as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we report that a branch of glycolysis, the serine biosynthesis pathway (SBP), is activated in regenerating muscle stem cells (MuSCs). Gene inactivation and metabolomics revealed that Psat1, one of the three SBP enzymes, controls MuSC activation and expansion of myogenic progenitors through production of the metabolite α-ketoglutarate (α-KG) and α-KG-generated glutamine. Psat1 ablation resulted in defective expansion of MuSCs and impaired regeneration. Psat1, α-KG, and glutamine were reduced in MuSCs of old mice. α-KG or glutamine re-established appropriate muscle regeneration of adult conditional Psat1 -/- mice and of old mice. These findings contribute insights into the metabolic role of Psat1 during muscle regeneration and suggest α-KG and glutamine as potential therapeutic interventions to ameliorate muscle regeneration during aging.

Keywords: aging; glutamine; ketoglutarate; muscle regeneration; muscle stem cells.

Published by cold spring harbor laboratory press.

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A research team led by Prof. Meng Guowen and Prof. Han Fangming from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, together with Prof. Wei Bingqing from the University of Delaware, miniaturized line-filtering capacitors with “matryoshka doll” structure electrodes, providing a high-performance and space-saving solution for line-filtering applications.

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The Tesla FSD V12.3 performs well in snowy conditions, demonstrating good acceleration, braking, and handling capabilities, as well as safety features such as pausing at intersections without stop signs.

Questions to inspire discussion.

How does the Tesla FSD V12.3 perform in snowy conditions?
—The Tesla FSD V12.3 performs well in snowy conditions, demonstrating good acceleration, braking, and handling capabilities.

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A new research paper has discovered the usefulness of DRAM cache for GPUs which can help enable higher performance at low power.

Researchers Propose The Use Of Dedicated DRAM Caches Onto Newly-Built SCMs For GPUs, Replacing Conventional HBM Configuration

The GPU industry, which involves consumer, workstation, and AI GPUs, is proceeding in a way that we are seeing advancements in memory capacities and bandwidth, but it isn’t sustainable, and ultimately, we could hit the limits if an innovative approach isn’t taken.

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Hydrogen gas is a clean fuel. It burns with oxygen in the air to provide energy with no CO2. Hydrogen is a key to sustainable energy for the future. Though humans are just now coming to realize the benefits of hydrogen gas (H2 in chemical shorthand), microbes have known that H2 is a good fuel for as long as there has been life on Earth. Hydrogen is ancient energy.

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A small research group from the University of Michigan has developed a three-legged skating/shuffling robot called SKOOTR that rolls as it walks, can move along in any direction and can even rise up to overcome obstacles.

The idea for the SKOOTR – or SKating, Omni-Oriented, Tripedal Robot – project came from assistant professor Talia Y. Moore at the University of Michigan’s Evolution and Motion of Biology and Robotics (EMBiR) Lab.

“I came up with this idea as I was rolling around on my office chair between groups of students,” said Moore. “I realized that the passively rolling office chair could easily spin in any direction, and I could use my legs to perform a variety of maneuvers while staying remarkably stable. I realized that this omnidirectional maneuverability is similar to how brittle stars change directions while swimming.”

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