The U.S. government is preparing to make moves to get food dyes out of what we eat– a plan which may spark curiosity across the nation as to what the potential health risks of artificial food dyes are.
Psychedelic use shows minimal link to schizotypal traits with possible reduction in delusional thinking, study suggests
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Psychedelic drugs are seeing a surge of interest from mainstream medicine, and initial results suggest that psychedelic-therapy can be a safe and effective treatment for some mental health conditions. However, the side-effect profile is still incompletely understood. In particular, the use of psychedelics has been posited to carry a risk of triggering latent psychotic disorders or persistent visual hallucinations, known as hallucinogen persisting perception disorder (HPPD).
In order to better understand the prevalence and risk factors of such side-effects, Katie Zhou and colleagues surveyed 654 people online who were planning to take psychedelics through their own initiative. The findings are published in the journal PNAS Nexus.
Of the 654 people surveyed, 315 people were resurveyed two weeks after their experience and 212 people were resurveyed again four weeks after their experience. The sample was 74% male, and 77% university-educated. About one-third had been diagnosed with at least one psychiatric condition.
Recurring dreams may feature taking a test the dreamer didn’t study for, having to make a speech or being attacked. Here’s why our sleeping brain comes back to these unpleasant dreams again and again
Utilizing ctDNA to discover mechanisms of resistance to targeted therapies in patients with metastatic NSCLC: towards more informative trials
Posted in biotech/medical | Leave a Comment on Utilizing ctDNA to discover mechanisms of resistance to targeted therapies in patients with metastatic NSCLC: towards more informative trials
Acquired resistance is a common occurrence among patients with oncogene-driven non-small-cell lung cancer receiving targeted therapies. Monitoring of circulating tumour DNA in liquid biopsy samples provides an appealing, minimally invasive method of monitoring for acquired resistance in this setting. However, research into detecting mechanisms of acquired resistance in liquid biopsy samples has thus far been limited by various challenges. In this Perspective, the authors describe the available data on detecting mechanisms of acquired resistance to targeted therapies in patients with non-small-cell lung cancer, as well as the various challenges to progress, such as a lack of a consensus definition of acquired resistance, and other inconsistencies in the approach to detecting and investigating these alterations.
This exercise “plays a crucial role in brain health, with increasing evidence linking it to a reduced risk of Alzheimer’s disease,” a doctor told Newsweek.
Sir William Crookes predicted plasma in 1879. Today, it’s fueling revolutionary space engines and automotive systems shaping our clean, high-tech future.
Scientists make incredible breakthrough that could help unleash limitless energy source: ‘Trying to make the design process as smooth as possible’
Posted in computing, innovation | Leave a Comment on Scientists make incredible breakthrough that could help unleash limitless energy source: ‘Trying to make the design process as smooth as possible’
To address issues in stellarator reactors, Princeton Plasma Physics Laboratory has developed its QUADCOIL computer code for optimizing and accelerating the design process.
Is it possible to build a Dyson sphere that isn’t catastrophically unstable? New research says yes, but only in one type of star system.
The metabolic fitness of microglia is markedly impaired in TREM2 knockout (KO) models [58]. TREM2, through its adaptors DAP12 and DAP10, activates the mechanistic target of rapamycin (mTOR) signaling pathway, which plays a crucial role in regulating metabolic pathways and protein synthesis [11, 58]. Loss of TREM2 impairs mTOR activation, leading to reduced ATP production and biosynthesis. In vivo FDG-PET imaging of TREM2 KO and TREM2 T66M knock-in mice shows a significant reduction in cerebral glucose metabolism [67, 68]. This decrease may correlate with impaired glucose uptake by microglia. Supporting this, ex vivo measurements of isolated microglia from TREM2 KO animals reveal lower FDG uptake [68].
Given the pivotal role of microglial metabolism in AD, targeting this process represents a promising therapeutic strategy. Agents such as interferon-γ (IFN-γ) and cyclocreatine, which enhance ATP production, have been shown to restore microglial functions and mitigate AD pathology [58, 65]. Notably, TREM2-activating antibodies boost microglial energy metabolism by promoting mitochondrial fatty acid and glucose oxidation [69]. Moreover, translocator protein (TSPO)-PET and FDG-PET imaging have demonstrated that TREM2 activation enhances microglial activity and glucose metabolism in amyloid mouse models. Thus, targeting TREM2 and microglial metabolism may complement existing AD therapies, which primarily focus on amyloid clearance and synaptic dysfunction, providing a more comprehensive approach to disease intervention.
Lipid metabolism is crucial for maintaining microglial functions and CNS homeostasis, influencing cellular membrane integrity, energy storage, and inflammatory responses. Emerging evidence identifies TREM2 as a key regulator of lipid metabolism in the brain. TREM2 binds a diverse range of lipids, including anionic and zwitterionic species such as sphingomyelin, phosphatidic acid, phosphatidylinositol, phosphatidylcholine, phosphatidylglycerol, phosphatidylserine (PtdSer) and sulfatide [49, 53, 70]. Among these, PtdSer is the most abundant negatively charged phospholipid in the inner leaflet of the plasma membrane in eukaryotic cells [71]. In neurodegenerative conditions, PtdSer externalization on damaged or apoptotic neurons serves as an “eat-me” signal, triggering TREM2-dependent microglial synaptic pruning and cell clearance [72]. Super-resolution microscopy and in vivo imaging studies have demonstrated that Aβ oligomer-induced hyperactive synapses expose PtdSer, marking them for TREM2-mediated engulfment, which helps mitigate neuronal hyperactivity in AD models. Additionally, individuals carrying TREM2 loss-of-function variants exhibit an accumulation of apoptotic-like synapses [72], underscoring TREM2’s essential role in synaptic homeostasis during early AD pathology. Beyond synaptic pruning, TREM2 facilitates the recognition and clearance of damaged cells. Notably, over-expression of TREM2 in non-phagocytic cells, such as Chinese hamster ovary (CHO) and HEK293 cells, enables them to engulf apoptotic neurons, highlighting TREM2’s function in lipid sensing and phagocytosis [16, 73]. This broad lipid-binding capability underscores TREM2’s critical role in modulating microglial responses to neurodegenerative insults and preserving neuronal health.