Blog – Page 16

European research led by University College London (UCL), together with Amsterdam UMC and the University of Basel, shows that a significant proportion of patients who suffer a stroke due to carotid artery narrowing can be treated with medication only.

A risky carotid artery operation, currently still the standard treatment for many patients, may then no longer be necessary for this group of patients. This research, published in The Lancet Neurology, may lead to the global guidelines for the treatment of these patients being adjusted.

In the Netherlands, about 2,000 people with carotid artery stenosis are operated on every year after they have had a stroke. Thirty years ago, large studies showed that an operation in which a narrowing in the carotid artery is removed reduced the risk of a new stroke.

Patients with ALS often lose their ability to speak making it harder to communicate with their family. This AI-powered device wants to change that.

The liver is the body’s control tower for metabolism, powering vital functions like converting nutrients to glucose, storing fat and breaking down toxins. Over a third of the world, however, is thought to be affected by conditions including metabolic dysfunction-associated steatotic liver disease (MASLD), which jeopardize key liver functions as the condition progresses. Hepatocyte organoids—the miniature, 3D models of the organ—hold immense promise for accelerating drug development and advancing regenerative therapies.

In a study published in Nature, Keio University researchers unveiled a method to proliferate these hard-to-grow organoids by a million-fold in just 3–4 weeks while maintaining key liver functions. “These organoids are potentially the closest laboratory representations of the liver and its multifunctionality,” says senior author Professor Toshiro Sato of the Keio University School of Medicine.

While organoids aim to mimic human organs, the liver’s repertoire of complex functions—and thus the energy it needs to operate—have made it challenging for researchers to grow organoids that proliferate and fully function, says Sato. When prioritizing growth and survival in laboratory settings, hepatocytes, the liver’s main cells, eventually transform into cells resembling cholangiocytes, which line the bile duct. Hepatocyte functions only last 1–2 weeks at most.