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The following is an interview with CRISPR co-discoverer and Nobel Prize-winner Dr. Jennifer Doudna.

Describe the “eureka moment” around CRISPR — the moment when you realized that this technology was not only possible but actually worked. How did you feel? Has your feeling changed since that eureka moment? If so, how?

There’s one moment that stands out in my mind, right at the time we realized what CRISPR could do and that we could “reprogram” it to edit specific sequences of DNA. I was cooking dinner and thinking about it, and I burst out laughing. My son was in the kitchen and he asked why I was laughing. So I explained it to him with a little drawing of a car zooming around, grabbing onto viruses, and chopping them up. I think my drawing did the trick, because he started laughing too.

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Cyrus Brodén, orthopedic physician and researcher at Uppsala University Hospital and Uppsala University.

Administrative tasks take up a large share of a doctor’s working hours, reducing the time for patient contact and contributing to a stressful work situation. Researchers at Uppsala University Hospital and Uppsala University, in collaboration with Danderyd Hospital and the University Hospital of Basel, Switzerland, have shown in a new study that the AI model ChatGPT can write administrative medical notes up to ten times faster than doctors without compromising quality.

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OpenAI on Friday revealed a voice-cloning tool it plans to keep tightly controlled until safeguards are in place to thwart audio fakes meant to dupe listeners.

A model called “Voice Engine” can essentially duplicate someone’s speech based on a 15-second audio sample, according to an OpenAI blog post sharing results of a small-scale test of the tool.

“We recognize that generating speech that resembles people’s voices has serious risks, which are especially top of mind in an election year,” the San Francisco-based company said.

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For the first time in history, world timekeepers may have to consider subtracting a second from our clocks in a few years because the planet is rotating a tad faster than it used to. Clocks may have to skip a second — called a “negative leap second” — around 2029, a new study in the journal Nature said.

“This is an unprecedented situation and a big deal,” said study lead author Duncan Agnew, a geophysicist at the Scripps Institution of Oceanography at the University of California, San Diego. “It’s not a huge change in the Earth’s rotation that’s going to lead to some catastrophe or anything, but it is something notable. It’s yet another indication that we’re in a very unusual time.”

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The full collection of top quark mass measurements by the CMS experiment! 🗝

What’s the best way to pin down the exact mass of this enigmatic particle? Discover the diverse strategies perfected by CMS over the last decade:

When it comes to top quark mass measurements, the CMS collaborati on has the largest and most complete collection of publication-quality results, cov ering a wide range of methods and approaches. In a recent review paper, an overview is given of all top quark mass measurements published by CMS so far. In the quest to pin down the exact mass of this enigmatic particle, different methods were developed and perfected over the last decade.

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The effects of aging on the immune system

The aging immune system is associated with reduced lymphopoiesis, increased inflammation, and myeloid diseases due to alterations in self-renewing HSCs. During childhood, bal-HSCs predominate, thereby facilitating lymphopoiesis and adaptive immune responses.

Age increases my-HSCs, which reduces lymphopoiesis and enhances myelopoiesis. Myeloid-HSC origin and possible interconversions are unclear; however, removing my-HSCs in aged mice may reverse the aging phenotype.

Continue reading “Turning back the clock on aging immune systems: New treatment rejuvenates elderly defenses” | >

Alzheimer’s is the most common form of dementia, affecting an estimated 6.7 million people in the US. Researchers seeking an effective treatment for the affliction have, over the last 30 years, focused their efforts on a protein known as amyloid beta (A-beta), which form clumps in the brain.

These clumps of A-beta proteins attack nerve cells, resulting initially in short-term memory impairment and later in the loss of judgment, language and thought processes.

Other researchers have previously developed an antibody which can identify and attach itself to A-beta proteins and delay the progression of Alzheimer’s in patients with early-to-mild cognitive impairment by up to 36%.

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Computer simulations are giving us new insight into the riotous behavior of cannibal neutron stars.

When a neutron star slurps up material from a close binary companion, the unstable thermonuclear burning of that accumulated material can produce a wild explosion that sends X-radiation bursting across the Universe.

How exactly these powerful eruptions evolve and spread across the surface of a neutron star is something of a mystery. But by trying to replicate the observed X-ray flares using simulations, scientists are learning more about their ins and outs – as well as the ultra-dense neutron stars that produce them.

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