Lifeboat Foundation

Acetamiprid-induced oxidative stress can harm DNA and tRNA, leading to health problems. A study conducted by Huixia Zhang at Macau University of Science and Technology in 2023 introduced a comprehensive approach to assessing acetamiprid-induced oxidative damage to tRNA in human cells through oxidized nucleotide and tRNA profiling. Acetamiprid, a modern insecticide, is known for causing oxidative stress and related toxicity. Despite its impact on oxidative stress, the effects of acetamiprid-induced oxidative stress on RNA, especially tRNA, remained unexplored until this study.

Acetamiprid was found to elevate reactive oxygen species (ROS) production in HepG2 and LO2 cells, contributing to mitochondrial damage, free radical generation, and antioxidant status depletion. Oxidative damage to DNA and RNA can harm organisms, with prior research addressing RNA damage in aging, neurodegenerative diseases, and mental illnesses. However, its role in acetamiprid-induced toxicities has not been investigated.

The study employed TMSD labeling-based LC-MS/MS to measure oxidized nucleotide levels in HepG2 and LO2 cells treated with two mM acetamiprid. It also examined the impact of acetamiprid on the 8-oxo-G content of tRNAs and created volcano plots to compare RNase T1 digestion products of tRNAs from untreated and acetamiprid-treated cells.

This brain-teaser has baffled physicists since 1883. Thanks to some innovative engineering, it finally makes sense.

QuEra aims to unleash a new era of innovation and discovery.

A new cybercriminal group, ResumeLooters, targets job search platforms in APAC, stealing millions of resumes and personal data.

Immune guardians called complement proteins are manufactured by gut cells and help to protect against pathogens.

Researchers have not only built an AI child, but are now training AI using headcam footage from a human baby as well.

In a press release, New York University announced that its data science researchers had strapped a camera to the head of a real, live, human toddler for 18 months to see how much an AI model could learn from it.

Most large language models (LLMs), like OpenAI’s GPT-4 and its competitors, are trained on “astronomical amounts of language input” that are many times larger than what infants receive when learning to speak a language during the first years of their lives.

A team of scientists at the University of Wisconsin-Madison claim to have 3D-printed functional human brain tissue for the first time.

They hope their research could open the doors for the development of treatments for existing neurological disorders, including Alzheimer’s and Parkinson’s disease.

As detailed in a new paper published in the journal Cell Stem Cell, the team flipped the usual method of 3D-printing on its side, fabricating horizontal layers of brain cells encased in soft “bio-ink” gel.

Kickstarter has been the graveyard for several high-profile 3D printers. The crowdfunding platform has also introduced numerous subpar 3D printers, alongside some truly outstanding ones. It was on Kickstarter that Formlabs soared to remarkable heights. The platform also brought us the 3D printing pen. There was a period when a new 3D printing project on Kickstarter emerged every week, but both Kickstarter and additive manufacturing (AM) have become considerably less bustling recently. In 2014, things were simpler, as there were far fewer 3D printers available. Now, with the advent of Bambu Labs and sophisticated open-source 3D printers like Prusas, making a significant impact has become much more challenging. NAW 3D is currently attempting to enter the market with a pellet 3D printer on Kickstarter.

The N300 Pellet 3D Printer

NAW3D’s N300 Desktop Pellet 3D Printer boasts an automatic pellet feeding system, with a 100g capacity consumables box and a 2000cm³ material storage space for continuous printing. Additionally, all axes are equipped with linear guides. What’s more, each stage of the printer incorporates double guides. The printer’s nozzles are capable of reaching temperatures up to 300°C. The print head is designed to deposit substantial amounts of material, with printing tracks ranging from 0.2 to 2mm. This capability suggests that the printer can handle both fine details and rapid, large-scale printing tasks.