Lifeboat Foundation

Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists at Scripps Research and the Albert Einstein College of Medicine have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.

The drug-like inhibitors block the virus from entering the body’s respiratory cells — specifically, they target hemagglutinin, a protein on the surface of type A influenza viruses. The findings, published in the Proceedings of the National Academy of Sciences on May 16, 2024, represent an important step forward in developing a drug that can prevent influenza infection.

“We’re trying to target the very first stage of influenza infection since it would be better to prevent infection in the first place, but these molecules could also be used to inhibit the spread of the virus after one’s infected,” says corresponding author Ian Wilson, DPhil, the Hansen Professor of Structural Biology at Scripps Research.

In recent years, my lab — or perhaps it’s just me — has developed an obsession with evolutionary transitions. The view that every gene originates from an ancestral state and undergoes impactful changes through its evolutionary journey, whether it’s the gain or loss of an activity or function. The challenge lies in meticulously mapping out these key evolutionary innovations that have significantly influenced function. Addressing this challenge is not merely interesting but absolutely essential in biology. Our aim as biologists transcends understanding how biological systems operate; we seek to unravel how they came to be. And the two questions are more connected than many think.

This post stems from my observation that molecular biologists sometimes appear indifferent to evolution, questioning its relevance to mechanistic research. It baffles me why the centrality of evolution in biology isn’t apparent to some. Maybe they’ve never taken a course on the subject, or perhaps they’ve never fully appreciated the profound concept that every organism and every gene is connected through an unbroken chain of descent to countless ancestors. This perspective holds profound implications for mechanistic molecular biology.

If you already appreciate the link between evolutionary biology and molecular mechanisms, you might find this post to be music to your ears. However, if you’re among those who question the value of evolutionary biology, I encourage you to stay with me; you might discover its significance in ways you hadn’t considered before.

May 2024 was the hottest May on record, marking a full annual cycle of monthly records, the longest ever recorded.

In research published earlier this year, physicists from the University of Hyderabad in India say they’re on the path to solving one of the universe’s biggest outstanding problems. Since Edwin Hubble realized the universe is always expanding nearly 100 years ago, scientists have used the “Hubble constant” in calculations on virtually every scale in the universe. But today, estimates for the Hubble constant don’t always align, with a difference of up to 10 percent between calculations made using different methods. (When someone at NASA mixes up meters and yards and loses an entire spacecraft, that’s not even a full 10 percent deviation.)

The paper appears in the peer reviewed journal Classical and Quantum Gravity. The journal has an ongoing, periodically updated “focus issue” specifically about this measurement tension, and the editors explain the problem there—scientists can’t say for sure that the different Hubble constants measured are actually different, rather than just observation or calibration issues.

When it comes to quantum computing, that chilling effect on research and development would enormously jeopardize U.S. national security. Our projects received ample funding from defense and intelligence agencies for good reason. Quantum computing may soon become the https://www.cyberdefensemagazine.com/quantum-security-is-nat...at%20allow, codebreaking%20attacks%20against%20traditional%20encryption" rel="noopener" class="">gold standard technology for codebreaking and defending large computer networks against cyberattacks.

Adopting the proposed march-in framework would also have major implications for our future economic stability. While still a nascent technology today, quantum computing’s ability to rapidly process huge volumes of data is set to revolutionize business in the coming decades. It may be the only way to capture the complexity needed for future AI and machine learning in, say, self-driving vehicles. It may enable companies to hone their supply chains and other logistical operations, such as manufacturing, with unprecedented precision. It may also transform finance by allowing portfolio managers to create new, superior investment algorithms and strategies.

Given the technology’s immense potential, it’s no mystery why China committed what is believed to be more than https://www.mckinsey.com/featured-insights/sustainable-inclu…n-quantum” rel=“noopener” class=””>$15 billion in 2022 to develop its quantum computing capacity–more than double the budget for quantum computing of EU countries and eight times what the U.S. government plans to spend.

Prototype quantum photonic-dimer laser uses entanglement to bind photons and deliver a powerful beam of concentrated light that can shine through adverse weather like thick fog.

From Stanford & Chan Zuckerberg Biohub TextGrad Automatic “Differentiation” via Text.

From stanford & chan zuckerberg biohub.

TextGrad.

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The Prompt Report.

A systematic survey of prompting techniques.

Sander schulhoff, michael ilie, nishant balepur, konstantine kahadze, amanda liu, chenglei si, yinheng li, aayush gupta, hyojung han, sevien schulhoff, pranav sandeep dulepet, saurav vidyadhara,…

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When compressed, nanoribbons of titanium and sulfur can change properties dramatically, turning into materials with the ability to conduct electricity without losing energy, according to a study published in the journal Nano Letters.