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Chemists create publicly available tool that provides unrivaled look at RNA inside cells

The interior of a cell is packed with proteins and nucleic acids, such as RNA, all of which need to perform specific functions at the exact right time. If they don’t, serious diseases—ALS, Huntington’s or many cancers—can result. But what exactly is happening inside the crowded cell when it malfunctions, and how can these miscues be prevented?

Thanks to a pair of chemists at the University of Massachusetts Amherst, a new publicly available tool called iConRNA provides an unrivaled look at the mysterious world RNA, and could help solve the mystery of how devastating diseases develop.

The research is published in the journal Proceedings of the National Academy of Sciences.

New molecular strategy achieves complete synthesis of anti-MRSA natural product

Spiroaspertrione A is a complex polycyclic compound naturally produced by the fungus Aspergillus sp. TJ23. First isolated in 2017, it quickly drew scientific attention for its promising ability to combat drug-resistant bacteria and restore their sensitivity to existing antibiotics.

Scientists have now found a way to carry out the total synthesis of the molecule in 16 steps, starting from a chiral pool building block called (+)-enoxolone that costs less than one euro per gram. The synthesis technique is presented in Science.

Staphylococcus aureus (staph) is a type of bacteria that quietly lives on our skin and in our noses. It usually does no harm, but when it turns invasive, it triggers dangerous infections like sepsis, pneumonia, and many hospital-acquired infections. What makes it truly alarming is its growing resistance to antibiotics, which can turn treatable infections into deadly threats.

Novel carbon nanotube-based transistors reach THz frequencies

Carbon nanotubes (CNTs), cylindrical nanostructures made of carbon atoms arranged in a hexagonal lattice, have proved to be promising for the fabrication of various electronic devices. In fact, these structures exhibit outstanding electrical conductivity and mechanical strength, both of which are highly favorable for the development of transistors (i.e., the devices that control the flow of current in electronics).

In recent years, several have started using CNTs to develop various electronics, including metal-oxide-semiconductor field-effect transistors (MOSFETs). MOSFETs are transistors that control the flow of current through a semiconducting channel utilizing an applied to a gate electrode.

Notably, when arrays of CNTs are used to develop MOSFETs, they can operate at (RF), the range of electromagnetic waves that support wireless communication. The resulting MOSFETs could thus be particularly advantageous for the advancement of wireless communication systems and technologies.

Scientists create a new form of light matter in a quasicrystal

Researchers have for the first time created a reconfigurable polariton 2D quasicrystal. The team from the Skolkovo Institute of Science and Technology (Skoltech), in collaboration with colleagues from the University of Iceland, the University of Warsaw, and the Institute of Spectroscopy of the Russian Academy of Sciences, demonstrated that this unique state of matter exhibits long-range order and a novel type of phase synchronization, opening new pathways for research into exotic phenomena such as supersolids and superfluidity in aperiodic settings.

The breakthrough, published in Science Advances, was achieved using exciton-polaritons—hybrid quasiparticles that are part light and part matter. By arranging these polaritons in a Penrose tiling, a famous aperiodic pattern with five-fold symmetry, the team observed the emergence of a macroscopic coherent state where the individual nodes synchronized in a nontrivial way, unlike anything seen in conventional periodic crystals.

Scientists Finally Hear Black Holes Ring, Confirming Hawking’s Famous Prediction

Ten years after the first detection of gravitational waves, scientists have captured the clearest signal yet — and it confirms one of Stephen Hawking’s most famous predictions.

Using the upgraded LIGO detectors, researchers observed two black holes colliding over a billion light-years away, producing space-time ripples so precise they could “hear” the black holes ring like cosmic bells.

A new window on the universe.

Why Organizations Are Abandoning Static Secrets for Managed Identities

“Using a secret manager dramatically improves the security posture of systems that rely on shared secrets, but heavy use perpetuates the use of shared secrets rather than using strong identities,” according to identity security researchers. The goal isn’t to eliminate secret managers entirely, but to dramatically reduce their scope.

Smart organizations are strategically reducing their secret footprint by 70–80% through managed identities, then using robust secret management for remaining use cases, creating resilient architectures that leverage the best of both worlds.

The Non-Human Identity Discovery Challenge

Nuclear power in your pocket? 50-year battery innovation

While the technology of nuclear batteries has been available since the 1950s, today’s drive to electrify and decarbonize increases the impetus to find emission-free power sources and reliable energy storage. As a result, innovations are bringing renewed focus to nuclear energy in batteries.

Nuclear batteries — those using the natural decay of radioactive material to create an electric current — have been used in space applications or remote operations such as arctic lighthouses, where changing a battery is difficult or even impossible. The Mars Science Laboratory rover, for example, uses radioisotopic power systems (RPS), which convert heat from radioactive decay into electricity via a thermoelectric generator. Betavolt’s innovation, 3, is a betavoltaic battery that uses beta particles rather than heat as its energy source. (Probably a repost from March 11 2024)

There are additional challenges that hinder the wider usage of these and all types of nuclear batteries, particularly material supply and discomfort with the use of radioactive materials. Yet, the physical and materials science behind this technology could unlock important advances for CO2-free energy and provide power for applications where currently available energy storage technologies are insufficient.

How do betavoltaic batteries work?

Betavoltaic batteries contain radioactive emitters and semiconductor absorbers. As the emitter material naturally decays, it releases beta particles, or high-speed electrons, which strike the absorber material in the battery, separating electrons from atomic nuclei in the semiconductor absorber. Separation of the resulting electron-hole pairs generates an electric current in the absorber, resulting in electrical power that can be delivered by the battery.

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