Lifeboat Foundation

The Advanced Research Projects Agency for Health (ARPA-H), an agency within the U.S. Department of Health and Human Services (HHS) announced a new funding opportunity through the launch of the PROactive Solutions for Prolonging Resilience, or PROSPR, program. The big question that drives the program is, “What if we had therapies to extend healthspan and prevent the onset of age-related diseases?”

ARPA-H PROSPR Program Manager Andrew Brack, Ph.D., says, “the ultimate goal is to extend healthspan—meaning the number of years aging adults live healthy lives and enjoy overall well-being by compressing the frailty and disability that comes with aging, into a shorter duration of time near the end of life.” The PROSPR program builds on foundational work by the National Institute of Aging and will work with industry and regulators to accelerate the testing and availability of new therapeutics targeted at healthspan.

This commitment by ARPA-H is not only an investment in national health, but an impactful economic investment. The number of people 65 and older accounts for 18% of the U.S. population and is projected to increase to 23% by 2054. Considering their increased care needs relative to younger ages, health care costs will increase by 75% if nothing is done to prevent the progressive loss of physical functioning during aging, according to a Pew Research Center Study. It is estimated that increasing the average American healthspan would lessen health care costs due to a combination of fewer medical needs, less reliance on assistance by others, and increased potential for individuals and their family caregivers to remain in the workforce. Because of these and other factors, it is estimated that extending healthspan by one year in only 10 percent of the aging population would reduce costs of U.S.

The trans–Tango genetic strategy, which mediates signaling across synapses, was adapted to identify neural connections in a vertebrate nervous system, with synaptic partners confirmed in the retina and spinal cord of larval zebrafish.

A UCLA study found that a diet low in omega-6 and high in omega-3 fatty acids, along with fish oil supplements, can significantly slow the growth of prostate cancer cells in men opting for active surveillance, potentially reducing the need for future aggressive treatments.

Researchers from UCLA Health Jonsson Comprehensive Cancer Center have found new evidence that dietary changes may slow cancer cell growth in men with prostate cancer undergoing active surveillance—a treatment approach that involves closely monitoring the cancer without immediate medical intervention.

Prostate Cancer and Dietary Intervention.

Physicists have created a new and long-lasting magnetic state in a material, using only light. They used a terahertz laser to stimulate atoms in antiferromagnetic materials, which could advance information processing and memory chip technology.

Lighting Up Hidden Magnetism with Terahertz Pulses: A New Frontier in Quantum Materials.

Imagine being able to control the magnetic properties of materials with flashes of light, unlocking states that last long after the light disappears. This groundbreaking approach to quantum materials is at the forefront of condensed-matter physics, offering tantalizing possibilities for future technologies.

Continue reading “Physicists magnetize a material with light” »

Genesis supports parallel simulation, making it ideal for training reinforcement learning (RL) locomotion policies efficiently. In this tutorial, we will walk you through a complete training example for obtaining a basic locomotion policy that enables a Unitree Go2 Robot to walk. With Genesis, you will be able to train a locomotion policy that’s deployable in real-world in less than 26 seconds (benchmarked on a RTX 4090).

Acknowledgement: This tutorial is inspired by and builds several core concepts from Legged Gym.

Your safety framework must include content filtering, output validation, rate limiting and detailed audit logging. I’ve found that implementing circuit breakers—automatic capability disablers triggered by anomalies—prevents small issues from becoming major incidents. For example, if an agent starts generating an unusual number of error responses, the system should automatically restrict its capabilities and alert the operations team.

Last year, I spoke to a tech company whose AI assistant became a victim of its own success. The system that flawlessly handled 1,000 daily requests crashed when usage jumped to 100,000 requests after a successful product launch. This taught us the importance of building for scale from day one. Even well-established companies like Netflix occasionally face challenges with scale, as seen during the recent live-streaming outages for the Jake Paul vs. Mike Tyson fight.

A production-ready architecture needs several key components working in harmony. The core engine should be modular, making updates and maintenance straightforward. Your integration layer should connect smoothly with enterprise systems through standardized APIs. Comprehensive monitoring helps you spot issues before they impact users, and robust memory management ensures consistent context handling across interactions.

While companies like Neuralink have recently provided some flashy demos of what could be achieved by hooking brains up to computers, the technology still has serious limitations preventing wider use.

Non-invasive approaches like electroencephalograms (EEGs) provide only coarse readings of neural signals, limiting their functionality. Directly implanting electrodes in the brain can provide a much clearer connection, but such risky medical procedures are hard to justify for all but the most serious conditions.

California-based startup Science Corporation thinks that an implant using living neurons to connect to the brain could better balance safety and precision. In recent non-peer-reviewed research posted on bioarXiv, the group showed a prototype device could connect with the brains of mice and even let them detect simple light signals.

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Hello and welcome! My name is Anton and in this video, we will talk about a major discovery in regards to the origins of life on Earth and the idea known as RNA World Hypothesis.
Links:
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00738-X
https://www.nature.com/articles/nrm.2017.7
https://theconversation.com/cells-have-more-mini-organs-than…als-239558
https://www.cell.com/biophysj/fulltext/S0006-3495(20)307…all%3Dtrue.
Previous videos:



https://youtu.be/DOUTF2cH4Ao.
https://youtu.be/UMJYVYX1VPg.

Continue reading “Strange RNA Based Structures Point at The Origins of Life (Biomolecular Condensates)” »

BERKELEY, Calif., Dec. 19, 2024 — Scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) used lasers and a supersonic sheet of gas to accelerate a high-quality beam of electrons to 10 billion electronvolts (eV) in just 30 cm. The energy and quality of the beam is a significant improvement compared to previous efforts.