Lifeboat Foundation

The natural ends of chromosomes appear alarmingly like broken DNA, much as a snapped spaghetti strand is difficult to distinguish from its intact counterparts. Yet every cell in our bodies must have a way of differentiating between the two because the best way to protect the healthy end of a chromosome also happens to be the worst way to repair damaged DNA.

Consider the enzyme telomerase, which is responsible for maintaining protective telomeres at the natural ends of chromosomes. Were telomerase to seal off a broken strand of DNA with a telomere, it would prevent further repair of that break and delete essential genes.

Now, a new study in Science describes how cells avoid such mishaps. These findings show that telomerase can indeed run amok, adding telomeres to damaged DNA, and would do so were it not for the ATR kinase, a key enzyme that responds to DNA damage.

Remote surgery in orbit.

Earth-bound surgeons remotely controlled a small robot aboard the International Space Station over the weekend, conducting the first-ever such surgery in orbit—albeit on rubber bands.

The experiment, deemed a “huge success” by the participants, represents a new step in the development of space surgery, which could become necessary to treat medical emergencies during multi-year manned voyages, such as to Mars.

Continue reading “Space surgery: Doctors on ground operate robot on ISS for first time” »

More than 4,500 heart transplants were performed in the U.S. in 2023. While the lifesaving operation improves the quality of life and longevity for most recipients, organ rejection remains a risk, with acute rejection occurring in up to 32% of recipients within the first year.

A team of researchers from Emory University, Case Western Reserve University and the University of Pennsylvania developed artificial intelligence tools to examine cardiac biopsy images to improve the prediction of rejection, helping to ensure patients receive the best possible post-transplant treatment.

Currently, clinicians rely on histologic grading of cardiac biopsies to diagnose acute rejection. However, there are limitations to the method, which assigns International Society of Heart and Lung Transplantation (ISHLT) histologic grades corresponding to no, mild, moderate and severe rejection.

A different method for inertial fusion shows promise as it achieves implosion and fusion.

Tech billionaires are funding research into controversial methods for cooling the planet.

By Corbin Hiar & E&E News

In creating five new isotopes, an international research team working at the Facility for Rare Isotope Beams (FRIB) at Michigan State University has brought the stars closer to Earth.

The isotopes —known as thulium-182, thulium-183, ytterbium-186, ytterbium-187 and lutetium-190—are reported in the journal Physical Review Letters.

These represent the first batch of new isotopes made at FRIB, a user facility for the U.S. Department of Energy Office of Science, or DOE-SC, supporting the mission of the DOE-SC Office of Nuclear Physics. The new isotopes show that FRIB is nearing the creation of nuclear specimens that currently only exist when ultradense celestial bodies known as neutron stars crash into each other.

A new study, resorting to computational models, predicts that a subduction zone currently below the Gibraltar Strait will propagate further inside the Atlantic and contribute to forming an Atlantic subduction system—an Atlantic ring of fire. This will happen ‘soon’ in geological terms—in approximately 20 million years.

Oceans seem eternal to our lifespan, but they are not here for long: they are born, grow, and one day close. This process, which takes a few hundred million years, is called Wilson Cycle. The Atlantic, for example, was born when Pangea broke up around 180 million years ago and will one day close. And the Mediterranean is what remains from a big ocean—the Tethys– that once existed between Africa and Eurasia.

For an ocean like the Atlantic to stop growing and start closing, new subduction zones—places where one tectonic plate sinks below another—have to form. But subduction zones are hard to form, as they require plates to break and bend, and plates are very strong. A way out of this “paradox” is to consider that subduction zones can migrate from a dying ocean in which they already exist—the Mediterranean—into pristine oceans—such as the Atlantic. This process was dubbed subduction invasion.

In an experiment akin to stop-motion photography, scientists have isolated the energetic movement of an electron while “freezing” the motion of the much larger atom it orbits in a sample of liquid water.

The findings, reported in the journal Science, provide a new window into the electronic structure of molecules in the liquid phase on a timescale previously unattainable with X-rays. The new technique reveals the immediate electronic response when a target is hit with an X-ray, an important step in understanding the effects of radiation exposure on objects and people.

“The chemical reactions induced by radiation that we want to study are the result of the electronic response of the target that happens on the attosecond timescale,” said Linda Young, a senior author of the research and Distinguished Fellow at Argonne National Laboratory.

The interior of black holes remains a conundrum for science. In 1916, German physicist Karl Schwarzschild outlined a solution to Albert Einstein’s equations of general relativity, in which the center of a black hole consists of a so-called singularity, a point at which space and time no longer exist. Here, the theory goes, all physical laws, including Einstein’s general theory of relativity, no longer apply; the principle of causality is suspended.

This constitutes a great nuisance for science—after all, it means that no information can escape from a black hole beyond the so-called event horizon. This could be a reason why Schwarzschild’s solution did not attract much attention outside the theoretical realm—that is, until the first candidate for a black hole was discovered in 1971, followed by the discovery of the black hole in the center of our Milky Way in the 2000s, and finally the first image of a black hole, captured by the Event Horizon Telescope Collaboration in 2019.

In 2001, Pawel Mazur and Emil Mottola proposed a different solution to Einstein’s field equations that led to objects that they called gravitational condensate stars, or gravastars. Contrary to black holes, gravastars have several advantages from a theoretical astrophysics perspective.