Lifeboat Foundation

Recent research from the S: CORT team has identified key biomarkers and treatment strategies that predict and enhance effectiveness of radiotherapy in rectal cancer treatment.

Patients with advanced rectal cancer often receive radiotherapy before surgery. However, despite this being standard practice, this treatment only results in complete disappearance (complete response) prior to surgery in 15% of patients.

Currently, there are no reliable biomarkers (a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease) to predict which colorectal patients will benefit from radiotherapy, meaning that many patients are unnecessarily exposed to significant side effects.

Google’s new Willow quantum processor has reignited discussions around blockchain security and their ability to withstand rapid advancements.

Researchers have discovered new connections between the gut and brain that hold promise for more targeted treatments for depression and anxiety, and could help prevent digestive issues in children by limiting the transmission of antidepressants during pregnancy.

The study, published in the journal Gastroenterology, shows that increasing serotonin in the gut epithelium—the thin layer of cells lining the small and large intestines—improves symptoms of anxiety and depression in animal studies. The researchers also found that, in humans, antidepressant use during pregnancy increases the risk of babies developing constipation in the first year of life.

“Our findings suggest that there may be an advantage to targeting antidepressants selectively to the gut epithelium, as systemic treatment may not be necessary for eliciting the drugs’ benefits but may be contributing to digestive issues in children exposed during pregnancy,” said Kara Margolis, director of the NYU Pain Research Center and associate professor of molecular pathobiology at NYU College of Dentistry, who co-led the study with Mark Ansorge, associate professor of clinical neurobiology at Columbia University.

More and more people under 50 have been diagnosed with bowel cancer in different parts of the world over the past few decades.

By Grace Wade

NASA’s James Webb Space Telescope (JWST) has for the first time captured an image of what our galaxy likely looked like just as it was forming — and it’s got space scientists feeling very Christmassy.

“I just love the sparkle galaxy with its Christmas lights shining as it was when the Universe was just 600 million years old,” Prof Catherine Heymans, Scotland’s Astronomer Royal, told BBC News.

The image shows ten balls of stars of different colours, appearing like Christmas tree baubles hanging in the cosmos.

Acting as an optics simulator, XLuminA explores all possible optical configurations.

Max Planck researchers developed an AI framework that autonomously designs microscopy experiments, optimizing it 10,000 times faster.

Continue reading “Max Planck’s AI-driven XLuminA boosts microscopy efficiency by 10,000x” »

HighlyCitedPapers.

📝 — Schulze, et al.

The present work reviews the strategies and technical approaches used to overcome the multilayered problems associated with large bone defect healing in long bones, with emphasis on research rooted in scaffold-guided tissue regeneration.

Continue reading “Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones” »

HighlyCitedPapers.

📝 The Many Faces of Immune Activation in HIV-1 Infection: A Multifactorial Interconnection — Mazzuti, et al.

Full text is available 👇

Continue reading “Patient-Derived Organoids: The Beginning of a New Era in Ovarian Cancer Disease Modeling and Drug Sensitivity Testing” »

Just a few months after the previous record was set, a start-up called Quantinuum has announced that it has entangled the largest number of logical qubits – this will be key to quantum computers that can correct their own errors.

By Karmela Padavic-Callaghan