Ancient bacteria that have evolved to become integral to our cells—converting nutrients from food into energy—may also contribute to neurologic disorders, such as spinal muscular atrophy (SMA) and autism, according to research in the lab of Yongchao Ma, Ph.D., from Ann & Robert H. Lurie Children’s Hospital of Chicago.
Called mitochondria, these mysterious parts of the cell have even retained their own DNA. Traditionally they are known as the “powerhouse of the cell.”
In recent years, however, mitochondria have been recognized as regulating many functions, including gene expression and how cells communicate. Dr. Ma’s research focuses on how dysregulation by mitochondria may lead to motor neuron degeneration in SMA or improper neuron connections in autism.