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Ever set off too many of the bitter taste receptors on your tongue? You probably spat out whatever it was in your mouth, and that’s our best guess for why we even have them: to stop us from ingesting things that might be harmful.

Our skin cells have the same receptors, which serve a similar purpose on a cellular level: to detect bitter substances. New research led by Okayama University of Science biologists builds on our knowledge of the type-2 taste receptors (TAS2Rs) found in the skin’s keratinocytes, finding their role is also to keep potentially harmful materials from sticking around and causing damage.

Once thought to be confined to the tongue, TAS2Rs are actually spread much further throughout the body. They line your colon, your stomach, and your upper airways.

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Maple syrup urine disease (MSUD) is a rare genetic inborn error of metabolism characterized by recurrent life-threatening neurologic crises and progressive brain injury. The disease is typically caused by biallelic mutations in genes (branched-chain α-ketoacid dehydrogenase E1α (BCKDHA), E1β (BCKDHB), or dihydrolipoamide branched-chain transacylase (DBT)) subunits which interact to form the mitochondrial BCKDH complex that decarboxylates ketoacid derivatives of leucine, isoleucine, and valine. MSUD can be treated by a strictly controlled diet or allogeneic liver transplantation.

Now, new work demonstrates that a gene therapy prevented newborn death, normalized growth, restored coordinated expression of the affected genes, and stabilized biomarkers in a calf as well as in mice.

This work is published in Science Translational Medicine in the paper, “BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease.”

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Brain-computer interfaces have enabled people with paralysis to move a computer cursor with their mind and reanimate their muscles with their thoughts. But the performance of the technology — how easily and accurately a BCI user’s thoughts move a cursor, for example—is limited by the number of channels communicating with the brain.

Science Corporation, one of the companies working towards commercial brain-computer interfaces(BCIs), is forgoing the traditional method of sticking small metal electrodes into the brain in favor of a biology-based approach to increase the number of communication channels safely. “What can I stick a million of, or what could I stick 10 million of, into the brain that won’t hurt it?” says Alan Mardinly, Science Corp co-founder.

The answer: Neurons.

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Amazon Web Services (AWS) on Thursday announced Ocelot, its first-generation quantum computing chip, as it enters the race against fellow tech giants in harnessing the experimental technology.

Developed by the AWS Center for Quantum Computing at the California Institute of Technology, the new chip can reduce the costs of implementing quantum error correction by up to 90%, according to the company.

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A plan to revive the mammoth is on track, scientists have said after creating a new species: the woolly mouse.

Scientists at the US biotechnology company Colossal Biosciences plan to “de-extinct” the prehistoric pachyderms by genetically modifying Asian elephants to give them woolly mammoth traits. They hope the first calf will be born by the end of 2028.

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Asteroids that orbit close to the Earth inevitably cause us some anxiety due to the even remote possibility of a collision. But their proximity also offers ample opportunities to learn more about the universe. Ryugu, a 900-meter diameter asteroid in the Apollo belt, has recently proven useful in our search for signs of life’s precursors elsewhere in our solar system.

A team of researchers at Kyoto University have found evidence of salt minerals in samples recovered from Ryugu during the initial phase of Japan’s Hayabusa2 mission. The discovery of these deposits, containing sodium carbonate, halite, and sodium sulfates, suggest that liquid saline water once existed within a parent body of Ryugu.

Before examining the samples, the team expected that sample grains returned from the asteroid might contain substances not generally found in meteorites. They anticipated that these could be highly water-soluble materials, which readily react with moisture in Earth’s atmosphere and are difficult to detect unless examined in their pristine state as preserved in the vacuum of space.

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Who hasn’t been there? The big meal is over, you’re full, but the craving for sweets remains. Researchers from the Max Planck Institute for Metabolism Research have now discovered that what we call the “dessert stomach” is rooted in the brain. The same nerve cells that make us feel full after a meal are also responsible for our craving for sweets afterwards.

To find the cause of the “dessert stomach,” the researchers investigated the reaction of mice to sugar and found that completely satiated mice still ate desserts. The paper is published in the journal Science.

Investigations of the brain showed that a group of nerve cells, the so-called POMC neurons, are responsible for this. These neurons became active as soon as the mice were given access to sugar, which facilitated their appetite.

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