Lifeboat Foundation

The European Commission is funding a 2-year, $312,000 study on the safety and ethical aspects of synthetic biology. From the introduction part of the site:

We will pursue our objectives by means of a fact-finding mission, contribution to the European “inaugural” Conference on Synthetic Biology in Zurich (SB 3.0), an open e-forum and an international workshop. The foreseen impact of our project will be no less than to stimulate a European debate on these issues at an early stage. Past experiences, especially in the field of GM-crops, have shown the importance of an early bio-safety and ethics debate. The community recognized this need, but up to now discussions are fragmentary. Our project aims to stimulate a European debate in a proactive way. That way we will contribute to the European synthetic biology community, supplementing genuine biosafety and bioethics aspects.

Looks like a great start on addressing a very important area of concern. For a blog post of mine that goes into a bit more detail on the issue of synthetic biology and its risks, see here.

Five evolutionary stages of pathogen progression from animals to human transmission have been identified A proposed monitoring system of viral chatter has been proposed to provide warning of new diseases before they spread to humans.

In 1999, Wolfe began field work in the jungles of Cameroon to track “viral chatter,” or the regular transmission of diseases from animals to people, usually without further spread among humans. By monitoring the habits and the blood pathologies of bushmeat hunters and their kills, Wolfe and his team have identified at least three previously unknown retroviruses from the same family as HIV, as well as promoted safe practices for handling animals and animal carcasses.

“The Cameroon project demonstrated that it’s possible to collect information on viral transmission under very difficult circumstances from these highly exposed people,” Wolfe said.

With Cameroon as a prototype and a $2.5 million National Institutes of Health Pioneer Award as seed money, Wolfe has gone on to create a network of virus-discovery projects that monitor hunters, butchers, and wildlife trade and zoo workers in some of the world’s most remote viral hotspots. The network of a dozen sites in China, the Democratic Republic of Congo, Malaysia, Laos, Madagascar and Paraguay include source locations for such emerging diseases as SARS, avian flu, Nipah, Ebola and monkeypox.

Continue reading “Researchers Endorse Global Early Warning System to Prevent Pandemics” »

If humanity ever meets lifeforms beyond Earth (or discovers our solitude in our galaxy) one thing will be sure–galactic historians will remark how interesting it must have been living in the nuclear age that “we now enjoy” (assuming we survive of course).

Speaking of nuclear, it seems that some scientists are utilizing a new drug that is showing major promises of fighting against radiation exposure, ensuring that victims not only survive, but remain “semi-healthy” as well.

(Space War) But now researchers at Washington University School of Medicine in St. Louis report they have developed an agent that protects cells from the lethal effects of radiation, regardless of whether it is given before or after exposure.

Using this agent in mice, the investigators found that the treatment helped shield rapidly dividing cells that are most vulnerable to radiation-induced death, providing proof in principle that it is possible to fend off radiation damage, according to a study published in the April issue of Biochemical and Biophysical Research Communications.

Continue reading “Could Anti-Radiation Drug Protect Us On Earth...And Mars?” »

In a report to be published in the peer-reviewed journal PLoS Computational Biology and currently available online, Sally Blower, a professor at the Semel Institute for Neuroscience and Human Behavior at UCLA, and Romulus Breban and Raffaele Vardavas, postdoctoral fellows in Blower’s research group, used novel mathematical modeling techniques to predict that current health policy — based on voluntary vaccinations — is not adequate to control severe flu epidemics and pandemics unless vaccination programs offer incentives to individuals.

According to the researchers, the severity of such a health crisis could be reduced if programs were to provide several years of free vaccinations to individuals who pay for only one year. Interestingly, however, some incentive programs could have the opposite effect. Providing free vaccinations for entire families, for example, could actually increase the frequency of severe epidemics. This is because when the head of the household makes a choice — flu shots or no flu shots — on behalf of all the other household members, there is no individual decision-making, and adaptability is decreased.

While other models have determined what proportion of the population would need to be vaccinated in order to prevent a pandemic, none of these models have shown whether this critical coverage can actually be reached. What has been missing, according to Blower, a mathematical and evolutionary biologist, is the human factor.

Continue reading “US flu control strategy flaws and suggested improvements” »

The Oxford Research Group has published “Beyond Terror: The Truth About the Real Threats to Our World”. The report focus on the disproportionate attention given to terrorism compared to the imminent threat from environmental degradation. The report looks at climate change, competition over resources, “marginalisation of the majority world” and global militarisation.

Read the entire report here.

Carnegie Mellon researchers Keith Florig and Baruch Fischhoff offer simple, practical advice: on whether it is worth citizens’ time to stock supplies needed for a home shelter, how urgently should one seek shelter following a nearby nuclear detonation, and how long should survivors remain in a shelter after the radioactive dust settles.

“A number of emergency-management organizations recommend that people stock their homes with a couple dozen categories of emergency supplies,” said Florig of Carnegie Mellon’s engineering and public policy department. “We calculated that it would cost about $240 per year for a typical family to maintain such a stock, including the value of storage space and the time needed to tend to it.”

Their research also suggests that many families who could afford to follow the stocking guidelines might think twice about whether the investment was really worth it, given the low probability that stocked supplies would actually be used in a nuclear emergency.

They advocate simple rules for minimizing risk based on how far people are from the blast. If you are within several miles of the blast, there will be no time to flee and you will have only minutes to seek shelter. If you are 10 miles [downwind] from the blast, you will have 15 to 60 minutes to find shelter, but not enough time to reliably flee the area before the fallout arrives,” said Florig.

However, the prior advice would suggest that if you are 10 miles from the blast that you could move perpendicular to the direction of the fallout plume and get out of the way in under 15 minutes. Needing to move one mile for smaller bombs. So I would think 10–20 miles downwind is a judgement call, but 25 miles you should be able to get out of the way of the fallout plume.

Cities that quickly closed schools and discouraged public gatherings had fewer deaths from the great flu pandemic in 1918 than cities that did not, researchers reported on Monday. Experts agree that a pandemic of some virus, most likely influenza, is almost 100 percent certain. What is not certain is when it will strike and which virus it will be.

In Kansas City, no more than 20 people could attend weddings or funerals. New York mandated staggered shifts at factories. In Seattle, the mayor told people to wear face masks.

No single action worked on its own, the researchers found, it was the combination of measures that saved lives. Peak death rates can be 50% to eight times lower. St. Louis authorities introduced “a broad series of measures designed to promote social distancing” as soon as flu showed up. Philadelphia downplayed the 1918 flu.

Philadelphia ended up with a peak death rate of 257 people per 100,000 population per week. St. Louis had just 31 per 100,000 at the peak.

Continue reading “Decisive, immediate action can reduce Pandemic Deaths” »

Here at the Lifeboat Foundation, we are pondering a website redesign. Are there any professional web designers in the audience who might be able to devote some evening/weekend time to brainstorming possible improvements and implementing them? If so, please get in contact with me via email.

Here is a small banner to put on your site if you want to link to us:

And one more:

Continue reading “Lifeboat Foundation Site Redesign” »

Never underestimate the power of a “do-over.”

Video gamers know exactly what I’m talking about: the ability to face a challenge over and over again, in most cases with a “reset” of the environment to the initial conditions of the fight (or trap, or puzzle, etc.). With a consistent situation and setting, the player is able to experiment with different strategies. Typically, the player will find the approach that works, succeed, then move on to the next challenge; occasionally, the player will try different winning strategies in order to find the one with the best results, putting the player in a better position to meet the next obstacle.

Real life, of course, doesn’t have do-overs. But one of the fascinating results of the increasing sophistication of virtual world and game environments is their ability to serve as proxies for the real world, allowing users to practice tasks and ideas in a sufficiently realistic setting that the results provide useful real life lessons. This capability is based upon virtual worlds being interactive systems, where one’s actions have consequences; these consequences, in turn, require new choices. The utility of the virtual world as a rehearsal system is dependent upon the plausibility of the underlying model of reality, but even simplified systems can elicit new insights.

The classic example of this is Sim City (which I’ve written about at length before), but with the so-called “serious games” movement, we’re seeing the overlap of gaming and rehearsal become increasingly common.

Continue reading “Rehearsing the Future” »