Lifeboat Foundation

Open source has emerged as a powerful set of principles for solving complex problems in fields as diverse as education and physical security. With roughly 60 million Americans suffering from a chronic health condition, traditional research progressing slowly, and personalized medicine on the horizon, the time is right to apply open source to health research. Advances in technology enabling cheap, massive data collection combined with the emerging phenomena of self quantification and crowdsourcing make this plan feasible today. We can all work together to cure disease, and here’s how.

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1. Language and cultural isolation lead to the situation then Russian researches are not known in West and vice versa. I spent a lot of time translating into Russian and promoting works of Bostrom, Yudkowsky, Circovic, D.Brin, Freitas, A.Kent and other writers on global risks. Here I would like to tell you about some Russian researchers. Though I can’t prove validity of their ideas I think they should be checked internationally in order to roll out them or to take preventive measures. A. V. Karnauhov created a theory of “green house” catastrophe. He shows that climate is non linear system this many positive feedbacks and one of them is often missed – it is that water vapor is also greenhouse gas and growing temperatures would lead to injection of more and more water vapor into atmosphere. Also current level of carbon dioxid should lead to much more temperature increase, but inertia of ocean temperature makes current temperature smaller. But ocean temperature will rise, especially in Arctic, where large amounts of methane stored under seebed on the low shallow waters. This would lead to clarhat gun explosion of metane. Cumulative effect of water vapor, CO₂, Metane and surmounting of ocean inertia will lead to very quick exponential global warming, which could have devastating effects as early as in 2020th and make global temperature higher not on 6 degrees but on several tens to the end of the century – which would mean human extinction, and after 200 years all life extinction on Earth Some his ideas you could see in the article: http://www.poteplenie.ru/doc/role.pdf Karnaukhov A.V. Role of the biosphere in the formation of the Earth’s Climate: The Greenhouse Catastrophe, Biophysics, Vol.46, No 6, 2001, pp. 1078–1088. Also I should mention works of Drobishevsky “Danger of the explosion of Callisto and the priority of space missions” http://www.springerlink.com/content/584mw0407824nt72/ He thinks that Jovian satellite Callisto could soon explode because of H and O reaction in its ice. Such explosion will lead to bombardment of the earth by comets and “nuclear winter” for 60 years. He suggested to send there a space mission. But I wrote him that, if he is write, it is very dangerous to send where mission, because it could trigger the explosion by drilling the ice crust. And the last man, about whom I would like to tell you, is a reviewer of my book “the Structure of the global catastrophe” Aranowich, who told me by way that his group has created much more effective way to penetrate the earth crust the Stevenson’s probe. Stevenson’s probe require 10 million ton of melted iron. His probe will weight only 10 tons and will use an energy of radioactive decay. It could reach 1000 km depth by one month – and the main danger is creation of supervolcano. Then I asked him, was any safety analysis done – he said not. But this is only theoretical work and no practical realization is planned.
2. I have wrote a book “The structure of global catastrophe” which aim was to investigate how different scenarios of global risks could interact in time, because all of them could realize in the XXI century. This book is sponsored by Russian Transhumanist movemet. Nick Bostrom wrote short preface to it. The book is mostly ready, but some editorial and organizational problems still persists. I hope it will be published by the end of the year.
3. I am started to translate this book into English. I have translated it by computer and then edit the result – now I am on the page 27 of 390. I need someone with native English who could help me to edit this translation. The book is here: http://avturchin.narod.ru/sgkengl2.doc I hope to finish English translation (in readable, but not high literature quality:) of the book until winter.
4. The shorter version of this book is already published on the name “War and 25 other scenarios of the End of the world”. This name was suggested by editorial house, the original name was: “Gnoseology of catastrophes”. The main idea of the book is that our inability to predict the future is equal to the end of the world.
5. I have translated the most part of Lifeboat site on Russian and I expect it will appear in the Net soon.
6. I have wrote several articles on the theme of global catastrophe: “Is SETI dangerous? English translation — http://www.proza.ru/texts/2008/04/12/55.html, “Atrophic principle and natural catastrophes” http://www.proza.ru/texts/2007/04/12-13.html and “About possibilities of manmade ignition of giant planets and other objects of Solar system” http://www.proza.ru/texts/2008/07/19/466.html which are in Russian.
7. I have created “Global catastrophic risks and human extinction library” there you could find many interesting literature on English and Russian. http://avturchin.narod.ru/Global.htm
8. I think that it is provable that if humanity will unite, it will have a chance to resist global risks, but if it will be divided on military competing parts, it almost doomed. Resent events on Caucasus put again in agenda the question of New cold war. Here we should ask what is the worst outcome of possible Cold war? Common answer is that Nuclear war is that worst outcome. But Nuclear war will not terminate all human population in most realistic scenarios. Much worse outcome is, I think, new arm race, which could lead to quick creation of much more destructive weapons, than nuclear. And the worst outcome of arm race is creation of Doomsday machine. Doomsday machine (DM) is ultimate defense weaponry. The example of such strategy was depicted by Kubrick in his genius movie “Dr. Strangelove”. Here we should say that DM-strategy is more suitable for a weaker state, which is in danger of aggression (or feels so). Quality of Russian nuclear forces is continue to deteriorating and minimum is expected around the year 2010 then most of old soviets rockets should be out of order. Simultaneously after the year 2010 US will rich a peak of their supremacy (because of thousand non nuclear cruise missiles, unique GPS system and antimissile shield it will have ability to make first strike without answer.), but later could lose supremacy because of economic crisis in US and growing arsenal of new Russian missiles. This situation looks dangerous, because from chess we know the principle: “Someone must attack under threat of losing his supremacy”. And antiballistic missile shield (ABM), which is developing now by NATO is very dangerous because it makes direct way to the creation of Doomsday Machine. Before ABM rockets were good as a mean of defense. But now only large underground bomb (gigaton order and with cobalt shield) could be a strategic defense. Such ideas is not only my creation but they are circulating in the air. Of course nobody is going to actually use such weapon, but it could be lunched accidentally. It should not be nuclear – it could be also large stockpile of anthrax, manmade supervulcano-threat or something more sophisticated. DM also could be used as a offensive mean. If Osama get it, he could say: everybody should convert in Islam, or I detonate it. The really big problem arise if in answer someone Catholic say: if anyone convert in Islam I will detonate my own Doomsday machine. In this case we finally doomed. But worst case scenarios are low probability ones, so I hope we have a chance to unite.

Following is a discussion of two potential threats to humanity – one which has existed for eons, the second we have seen recently resurfacing having thought it had been laid to rest.

First, a recent story on PhysOrg describes the work researchers at Vanderbilt University have performed in isolating antibodies from elderly people who had survived the 1918 flu pandemic. This comes three years after researchers at Mount Sinai and the Armed Forces Institute of Pathology in Washington, D.C isolated the same virus which caused this outbreak from the frozen bodies of people in Alaska who had died in the pandemic.

In addition to being an impressive achievement of biomedical science, which involved isolating antibody-secreting B cells from donors and generating “immortalized” cell lines to produce large amounts of antibodies, this research also demonstrates the amazing memory the immune system has (90 years!), as well as the ability scientists have to use tissue samples from people born nearly a century ago and fashion them into a potential weapon against future similar outbreaks. Indeed, these manufactured antibodies proved effective against 1918 flu virus when tested in mice.

Continue reading “Threats to humanity – the old and the resurgent” »

The Singularity Institute for Artificial Intelligence has announced the details of The Singularity Summit 2008. The event will be held October 25, 2008 at the Montgomery Theater in San Jose, California. Previous summits have featured Nick Bostrom, Eric Drexler, Douglas Hofstadter, Ray Kurzweil, and Peter Thiel.

Keynote speakers include Ray Kurzweil, author of The Singularity is Near, and Justin Rattner, CTO of Intel. At the Intel Developer Forum on August 21, 2008, Rattner explained why he thinks the gap between humans and machines will close by 2050. “Rather than look back, we’re going to look forward 40 years,” said Rattner. “It’s in that future where many people think that machine intelligence will surpass human intelligence.”

Other featured speakers include:

• Dr. Ben Goertzel, CEO of Novamente, director of research at SIAI
• Dr. Marvin Minsky
• Nova Spivack, CEO of Radar Networks, creator of Twine.com
• Dr. Vernor Vinge
• Eliezer Yudkowsky

You can find a comprehensive list of other upcoming Singularity and Artificial Intelligence events here.

Something to post to your websites and to vote online.

Aubrey de Grey can get $1.5 million for the Methuselah Foundation if enough people vote.

Voting ends September 1st, take a second to vote now.
Any US Amex cardmember or US resident (who makes a guest account) can vote.

Here is the page where you can vote “nominate”

The Methuselah Foundation Page with some more details if you are interested, to vote though you only need click on the above link…

The UK’s Guardian today published details of a report produced by Britain’s Security Service (MI5) entitled, ‘Understanding radicalization and violent extremism in the UK’. The report is from MI5’s internal behavioral analysis unit and contains within it some interesting and surprising conclusions. The Guardian report covers many of these in depth (so no need to go over here) but one point, which is worth highlighting is the claim made within the report that religion is and was not a contributory factor in the radicalization of the home-grown terrorist threat that the UK faces. In fact, the report goes on to state that a strong religious faith protects individuals from the effects of extremism.This viewpoint is one that is gathering strength and coincides with an article written by Martin Amis in the Wall Street Journal, which also argues that ‘terrorism’s new structure’ is about the quest for fame and thirst for power, with religion simply acting as a “means of mobilization”.

All of this also tends to agree with the assertion made by Philip Bobbit in ‘Terror and Consent’, that al-Qaeda is simply version 1.0 of a new type of terrorism for the 21st century. This type of terrorism is attuned to the advantages and pressures of a market based world and acts more like a Silicon Valley start-up company than the Red Brigades — being flexible, fast moving and wired — taking advantage of globalization to pursue a violent agenda.

This all somewhat begs the question of, what next? If al-Qaeda is version 1.0 what is 2.0? This of course is hard to discern but looking at the two certain trends, which will shape humanity over the next 20 years — urbanization and virtualization — throws up some interesting potential opponents who are operating today. The road to mass urbanization is currently being highlighted by the 192021 project (19 cities, 20 million people in the 21st century) and amongst other things, points to the large use of slum areas to grow the cities of the 21st century. Slum areas are today being globally exploited from Delhi to Sao Paulo by Nigerian drug organizations that are able to recruit the indigenous people to build their own cities within cities. This kind of highly profitable criminal activity in areas beyond the vision of government is a disturbing incubator.

Increased global virtualization complements urbanization as well as standing alone. Virtual environments provide a useful platform for any kind of real-life extremist (as is now widely accepted) but it is the formation of groups within virtual spaces that then spill-out into real-space that could become a significant feature of the 21st century security picture. This is happening with, ‘Project Chanology’ a group that was formed virtually with some elements of the Anonymous movement in order to disrupt the Church of Scientology. While Project Chanology (WhyWeProtest Website)began as a series of cyber actions directed at Scientology’s website, it is now organizing legal protests of Scientology buildings. A shift from the virtual to the real. A more sinister take on this is the alleged actions of the Patriotic Nigras — a group dedicated to the disruption of Second Life, which has reportedly taken to using the tactic of ‘swatting’ — which is the misdirection of armed police officers to a victim’s home address. A disturbing spill-over into real-space. Therefore, whatever pattern future terrorist movements follow, there are signs that religion will play a peripheral rather than central role.

Originally posted on the Counterterrorism blog.

Read our new report 23 Things Science Can Tell Us about Life, the Universe, and Everything and post your comments here!

My proposal for the Society for Risk Analysis’s annual meeting in Boston has been accepted, in oral presentation format, for the afternoon of Wednesday, December 10th, 2008. Any Lifeboat members who will be in the area at the time are more than welcome to attend. Any suggestions for content would also be greatly appreciated; speaking time is limited to 15 minutes, with 5 minutes for questions. The abstract for the paper is as follows:

Global Risk: A Quantitative Analysis

The scope and possible impact of global, long-term risks presents a unique challenge to humankind. The analysis and mitigation of such risks is extremely important, as such risks have the potential to affect billions of people worldwide; however, little systematic analysis has been done to determine the best strategies for overall mitigation. Direct, case-by-case analysis can be combined with standard probability theory, particularly Laplace’s rule of succession, to calculate the probability of any given risk, the scope of the risk, and the effectiveness of potential mitigation efforts. This methodology can be applied both to well-known risks, such as global warming, nuclear war, and bio-terrorism, and lesser-known or unknown risks. Although well-known risks are shown to be a significant threat, analysis strongly suggests that avoiding the risks of technologies which have not yet been developed may pose an even greater challenge. Eventually, some type of further quantitative analysis will be necessary for effective apportionment of government resources, as traditional indicators of risk level- such as press coverage and human intuition- can be shown to be inaccurate, often by many orders of magnitude.

More details are available online at the Society for Risk Analysis’s website. James Blodgett will be presenting on the precautionary principle two days earlier (Monday, Dec. 8th).

Researchers have devised a rapid and efficient method for generating protein sentinels of the immune system, called monoclonal antibodies, which mark and neutralize foreign invaders.

For both ethical and practical reasons, monoclonals are usually made in mice. And that’s a problem, because the human immune system recognizes the mouse proteins as foreign and sometimes attacks them instead. The result can be an allergic reaction, and sometimes even death.

To get around that problem, researchers now “humanize” the antibodies, replacing some or all of mouse-derived pieces with human ones.

Wilson and Ahmed were interested in the immune response to vaccination. Conventional wisdom held that the B-cell response would be dominated by “memory” B cells. But as the study authors monitored individuals vaccinated against influenza, they found that a different population of B cells peaked about one week after vaccination, and then disappeared, before the memory cells kicked in. This population of cells, called antibody-secreting plasma cells (ASCs), is highly enriched for cells that target the vaccine, with vaccine-specific cells accounting for nearly 70 percent of all ASCs.

Continue reading “30 days to make antibodies to limit Pandemics” »