China’s latest tool can sever communication and power cables located deep in the oceans, giving it the power to disrupt global infrastructure.
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Study coauthors include UC’s Sreekar Puchala and Anca Ralescu and Ethan Muchnik of the University of Oregon. The study authors declare no competing interests.
This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Defense Medical Research and Development Program under Award No. W81XWH-16–2–0020. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.
The Impact of Socio-Economic Challenges and Technological Progress on Economic Inequality: An Estimation with the Perelman Model and Ricci Flow Methods
Posted in economics, innovation | Leave a Comment on The Impact of Socio-Economic Challenges and Technological Progress on Economic Inequality: An Estimation with the Perelman Model and Ricci Flow Methods
Keywords: technological advances, economical inequality, GinI coefficient, Ricci flow, Perelman models, technological innovations, research and development, innovations, sensitive analyze, automatization, economic stability, socio-economic challenges.
JEL Classification: E22, O11, O32.
Cite as: Gondauri, D. (2024). SocioEconomic Challenges, 8, 161–175. https://doi.org/10.61093/sec.8.161-175.2024.
Genome sequencing of cancer and normal tissues, alongside single-cell transcriptomics, continues to produce findings that challenge the idea that cancer is a ‘genetic disease’, as posited by the somatic mutation theory (SMT). In this prevailing paradigm, tumorigenesis is caused by cancer-driving somatic mutations and clonal expansion. However, results from tumor sequencing, motivated by the genetic paradigm itself, create apparent ‘paradoxes’ that are not conducive to a pure SMT. But beyond genetic causation, the new results lend credence to old ideas from organismal biology. To resolve inconsistencies between the genetic paradigm of cancer and biological reality, we must complement deep sequencing with deep thinking: embrace formal theory and historicity of biological entities, and (re)consider non-genetic plasticity of cells and tissues. In this Essay, we discuss the concepts of cell state dynamics and tissue fields that emerge from the collective action of genes and of cells in their morphogenetic context, respectively, and how they help explain inconsistencies in the data in the context of SMT.
Citation: Huang S, Soto AM, Sonnenschein C (2025) The end of the genetic paradigm of cancer. PLoS Biol 23: e3003052. https://doi.org/10.1371/journal.pbio.
Copyright: © 2025 Huang et al. This is an open access distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A breathable cardiac electronic skin possesses ICU-grade accuracy, outstanding stability, and biocompatibility.
Plastic consumption in seabirds causes blood signatures of widespread organ damage including brain, stomach, kidney, and liver.
A new method inspired by coral reefs can capture carbon dioxide from the atmosphere and transform it into durable, fire-resistant building materials, offering a promising solution for carbon-negative construction.
The approach, developed by USC researchers and detailed in a study published in npj Advanced Manufacturing, draws inspiration from the ocean’s coral reefs’ natural ability to create robust structures by sequestering carbon dioxide. The resulting mineral-polymer composites demonstrate extraordinary mechanical strength, fracture toughness and fire-resistance capabilities.
“This is a pivotal step in the evolution of converting carbon dioxide,” said Qiming Wang, associate professor of civil and environmental engineering at the USC Viterbi School of Engineering. “Unlike traditional carbon capture technologies that focus on storing carbon dioxide or converting it into liquid substances, we found this new electrochemical manufacturing process converts the chemical compound into calcium carbonate minerals in 3D-printed polymer scaffolds.”
If you’ve ever noticed how memories from the same day seem connected while events from weeks apart feel separate, a new study reveals the reason: Our brains physically link memories that occur close in time not in the cell bodies of neurons, but rather in their spiny extensions called dendrites.
This discovery stems from studies in mice, in which researchers observed memory formation using advanced imaging techniques, including miniature microscopes that captured single-cell resolution in live animals.
The study shows that memories are stored in dendritic compartments: When one memory forms, the affected dendrites are primed to capture new information arriving within the next few hours, linking memories formed close in time.