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Chan Zuckerberg Initiative’s rBio uses virtual cells to train AI, bypassing lab work

The Chan Zuckerberg Initiative announced Thursday the launch of rBio, the first artificial intelligence model trained to reason about cellular biology using virtual simulations rather than requiring expensive laboratory experiments — a breakthrough that could dramatically accelerate biomedical research and drug discovery.

The reasoning model, detailed in a research paper published on bioRxiv, demonstrates a novel approach called “soft verification” that uses predictions from virtual cell models as training signals instead of relying solely on experimental data. This paradigm shift could help researchers test biological hypotheses computationally before committing time and resources to costly laboratory work.

Groundbreaking new cancer detection replaces toxic compounds with diamonds

Scientists have developed a diamond-based sensor that could make it easier for doctors to detect the spread of cancer.

Researchers at the University of Warwick have created a handheld device that is designed to trace tiny magnetic particles injected into the body.

The scientists said this offers a non-toxic alternative to radioactive tracers and dyes currently used in hospitals.

Cold plasma penetrates deep into tissue to fight cancer

Researchers at the Leibniz Institute for Plasma Science and Technology (INP) have collaborated with partners at Greifswald University Hospital and University Medical Center Rostock to demonstrate that cold plasma can effectively combat tumor cells even in deeper tissue layers.

What is particularly noteworthy is that, by developing new models, they were able to precisely investigate the effect of individual plasma components on tumor cells for the first time. The research is published in the journal Trends in Biotechnology.

Scientists solve 30-year mystery of a hidden nutrient that shields the brain and fights cancer

Scientists have finally uncovered the missing link in how our bodies absorb queuosine, a rare micronutrient crucial for brain health, memory, stress response, and cancer defense. For decades, researchers suspected a transporter had to exist, but it remained elusive—until now.

Zooming in reveals a world of detail: Protein mapping technique reveals inner workings of cells

In the past decade, there has been significant interest in studying the expression of our genetic code down to the level of single cells, to identify the functions and activities of any cell through the course of health or disease.

The identity of a cell, and the way that identity can go awry, is critical to its role in many of the biggest health challenges we face, including cancer, neurodegeneration, or genetic and developmental disorders. Zooming in on single cells allows us to tell the difference between variants which would otherwise be lost in the average of a region. This is essential for finding new medical solutions to diseases.

Most single-cell gene expression experiments make use of a technology called single-cell RNA sequencing (scRNA-seq), which produces a map of exactly which genes are being copied out into short “transcripts” inside the nucleus. However, scRNA-seq only gives us a window into the intermediate step between the genetic code and the proteins which take care of (almost) all the tasks inside our bodies.

Off-the-shelf cancer vaccine elicits strong immune response in patients with pancreatic and colorectal cancer

The findings, published in Nature Medicine, show that the vaccine can trigger powerful and lasting immune responses and may help prevent or delay cancer recurrence in high-risk patients whose tumors are driven by KRAS mutations.

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