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Networks are mathematical representations to explore and understand diverse, complex systems—everything from military logistics and global finance to air traffic, social media, and the biological processes within our bodies. In each of those systems, a hierarchy of recurring, meaningful internal patterns—such as molecules and proteins interacting inside cells, and capacitors and resistors operating within integrated circuits—determines the functions or behaviors of those systems. The larger and more intricate a system is, however, the harder it is for current network modeling techniques to uncover these patterns and represent them in organized, easy-to-understand ways.

Researchers at Stanford University, funded by DARPA’s Simplifying Complexity in Scientific Discovery (SIMPLEX) program, have made progress in overcoming these challenges through a framework they have developed for identifying and clustering what mathematicians call “motifs”: essential but often obscure patterns within systems that are the building blocks of mathematical modeling and that facilitate the computational representation of complex systems.

A research paper describing the team’s achievement was published in Science (“Higher-order organization of complex networks”). At the heart of the team’s success was the creation of algorithms that can automatically explore and prioritize the hidden patterns in data that are fundamental to explaining network structure and function.

a mathematical framework that automatically identifies and prioritizes the patterns that are fundamental to explaining network structure and function

I just last week saw the movie Neon Demon. The movie explores pathology of prettiness, and to what degree people demand to consume prettiness. This is a particularly futurist topic, as society might change a lot with regards to commidifying as well as synthesizing completely new forms of beauty. This arouses deep seated fears. We fear those who manipulate desire (love, lust, loneliness, among others) for their own benefit. But many in the field claim “it is just another job”. Is relationship now part of the “gig economy” or should our politicians interfere? Will a basic income increase these forms of prostitution or decrease them?

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For all my Precision Medicine, Cancer researchers, and anti-aging friends researchers have id that the mitochondria pathway has been used by cancer cells to exploit for motility and metastasis.


Researchers have identified a new mitochondrial pathway that cancer cells exploit for motility and metastasis—providing a viable, “druggable” target for many different types of tumors. [NIEHS].

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Being treated for high cholesterol with statins is being linked with a reduced risk of death and better survival from four common cancers, a medical conference has heard.

Among the patients in the study, almost 8,000 had lung cancer, 5,500 had breast cancer, 4,600 had prostate cancer and 4,500 had colon cancer, the researchers found. So the researchers think the statin treatment might explain the protective effect, rather than high cholesterol itself.

Data for patients admitted to United Kingdom hospitals between January 1, 2000-March 31, 2013 with the listed cancers were obtained from the Algorithm for Comorbidities, Associations, Length of stay and Mortality (ACALM) clinical database, which also provided data on comorbidities such as high cholesterol; mortality data was obtained from the Office of National Statistics.