In an observational study, noninvasive respiratory support was associated with disease slowing for ALS patients, regardless of stage or site of onset.
Alpha ketoglutarate, or AKG, has long been used as a dietary supplement in the bodybuilding world.
By satisfying bioenergetic demands, generating biomass, and providing metabolites serving as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we report that a branch of glycolysis, the serine biosynthesis pathway (SBP), is activated in regenerating muscle stem cells (MuSCs). Gene inactivation and metabolomics revealed that Psat1, one of the three SBP enzymes, controls MuSC activation and expansion of myogenic progenitors through production of the metabolite α-ketoglutarate (α-KG) and α-KG-generated glutamine. Psat1 ablation resulted in defective expansion of MuSCs and impaired regeneration. Psat1, α-KG, and glutamine were reduced in MuSCs of old mice. α-KG or glutamine re-established appropriate muscle regeneration of adult conditional Psat1 -/- mice and of old mice. These findings contribute insights into the metabolic role of Psat1 during muscle regeneration and suggest α-KG and glutamine as potential therapeutic interventions to ameliorate muscle regeneration during aging.
Keywords: aging; glutamine; ketoglutarate; muscle regeneration; muscle stem cells.
A research team led by Prof. Meng Guowen and Prof. Han Fangming from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, together with Prof. Wei Bingqing from the University of Delaware, miniaturized line-filtering capacitors with “matryoshka doll” structure electrodes, providing a high-performance and space-saving solution for line-filtering applications.
The Tesla FSD V12.3 performs well in snowy conditions, demonstrating good acceleration, braking, and handling capabilities, as well as safety features such as pausing at intersections without stop signs.
Questions to inspire discussion.
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A new research paper has discovered the usefulness of DRAM cache for GPUs which can help enable higher performance at low power.
Researchers Propose The Use Of Dedicated DRAM Caches Onto Newly-Built SCMs For GPUs, Replacing Conventional HBM Configuration
The GPU industry, which involves consumer, workstation, and AI GPUs, is proceeding in a way that we are seeing advancements in memory capacities and bandwidth, but it isn’t sustainable, and ultimately, we could hit the limits if an innovative approach isn’t taken.
The advanced artificial intelligence model powering Copilot’s Pro tier wasn’t free to all until now.
SpaceX’s president and COO has one priority for the next test-flight: ‘getting reentry right.’
Hydrogen gas is a clean fuel. It burns with oxygen in the air to provide energy with no CO2. Hydrogen is a key to sustainable energy for the future. Though humans are just now coming to realize the benefits of hydrogen gas (H2 in chemical shorthand), microbes have known that H2 is a good fuel for as long as there has been life on Earth. Hydrogen is ancient energy.
Spring weather brings welcome conditions for flowers and plant life to bloom across the land. The right mixture of temperature, moisture, and light helps keep the green world vibrant.
