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Over the past several years, DARPA-funded researchers have pioneered RNA vaccine technology, a medical countermeasure against infectious diseases that uses coded genetic constructs to stimulate production of viral proteins in the body, which in turn can trigger a protective antibody response. As a follow-on effort, DARPA funded research into genetic constructs that can directly stimulate production of antibodies in the body., DARPA is now launching the Pandemic Prevention Platform (P3) program, aimed at developing that foundational work into an entire system capable of halting the spread of any viral disease outbreak before it can escalate to pandemic status. Such a capability would offer a stark contrast to the state of the art for developing and deploying traditional vaccines—a process that does not deliver treatments to patients until months, years, or even decades after a viral threat emerges.

“DARPA’s goal is to create a technology platform that can place a protective treatment into health providers’ hands within 60 days of a pathogen being identified, and have that treatment induce protection in patients within three days of administration. We need to be able to move at this speed considering how quickly outbreaks can get out of control,” said Matt Hepburn, the P3 Program Manager. “The technology needs to work on any viral disease, whether it’s one humans have faced before or not.”

Recent outbreaks of viral infectious diseases such as Zika, H1N1 influenza, and Ebola have cast into sharp relief the inability of the global health system to rapidly contain the spread of a disease using existing tools and procedures. State-of-the-art medical countermeasures typically take many months or even years to develop, produce, distribute, and administer. These solutions often arrive too late—if at all—and in quantities too small to respond to emerging threats. In contrast, the envisioned P3 platform would cut response time to weeks and stay within the window of relevance for containing an outbreak.

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The machine-learned smarts that enable Microsoft’s Skype Translator, Bing and Cortana to accomplish tasks such as translating conversations, compiling knowledge and understanding the intent of spoken words are increasingly finding their way into third-party applications that people use every day.

These advances in the democratization of artificial intelligence are coming in part from Microsoft Cognitive Services, a collection of 25 tools that allow developers to add features such as emotion and sentiment detection, vision and speech recognition, and language understanding to their applications with zero expertise in machine learning.

“Cognitive Services is about taking all of the machine learning and AI smarts that we have in this company and exposing them to developers through easy-to-use APIs, so that they don’t have to invent the technology themselves,” said Mike Seltzer, a principal researcher in the Speech and Dialog Research Group at Microsoft’s research lab in Redmond, Washington.

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DNA — now with a new base pair! (credit: Romesberg Lab)

Scientists at The Scripps Research Institute (TSRI) have developed the first stable semisynthetic organism — a bacterium with two new synthetic bases (called X and Y) added to the four natural bases (A, T, C, and G) that every living organism possesses. Adding two more letters to expand the genetic alphabet can be used to make novel proteins for new therapeutics, according to the researchers.

All life as we currently know it contains just four bases that pair up to form two “base pairs” — the rungs of the DNA ladder — which are simply rearranged to create different organisms.

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Innocorp has a new drone that is a flying submarine. It is an unmanned underwater vehicle (UUV), unmanned aerial vehicle (UAV) drone and iot can transitio from water to air to land without any individual or multiple deployments, fission of elements, (as in rockets), or complicated maneuvering.

Like the Murres, a unique seabird which can circumnavigate in the air and in water, SubMurres does both in unprecedented fashion. SubMurres has all the key features of a submarine, including complete marine functionality, communication tower with periscope for panoramic viewing of above-water landscape, dual propulsion blades, fully-articulated rotors that emerge as needed, sensors, and more. But it doesn’t end there.

The dual submarine aircraft moves ubiquitously from water to air. As a submarine, Submurres glide silently underwater performing its mission as it surfaces. Once on the water surface its flight system is engaged and its four rotors emerge from their compartments as vertical take-off and landing (VTOL) is initiated. Once airborne, there is no expulsion of parts. SubMurres simply flies unfettered, with all components intact. Its landing apparatus allow it to settle on terrain, and its second camera system allows it to fully capture surroundings. From land, it can be directly re-dispatched to water. No need to redeploy or to be picked up by another carrier aircraft, unlike any of the chief aeronautic industry or Navy-funded university’s latest submersive drone models.

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Research can seem bland to us laypersons. But, Marko Vukolić shares many of my research interests and he exceeds my academic credentials (with just enough overlap for me to understand his work). So, in my opinion, his writing is anything but bland…

Vukolić started his career as a post-doc intern at IBM in Zurich Switzerland. After a teaching stint as assistant professor at Eurecom and visiting professor at ETH Zurich, he rejoined the IBM research staff in both cloud computing infrastructure and the Blockchain Group.*

As a researcher and academic, Vukolić is a rising star in consensus-based mechanisms and low latency replicated state machines. At Institut Mines-Télécom in Paris, he wrote papers and participated in research projects on fault tolerance, scalability, cloud computing and distributed trust mechanisms.

Now, at IBM Zurich, Vukolić has published a superior analysis addressing the first and biggest elephant in the Bitcoin ballroom, Each elephant addresses an urgent need:

  • Scalability & throughput
  • Incentivize (as mining reward withers)
  • Grow & diversify governance & geographic influence
  • Anonymize transactions to protect privacy
  • Recognize & preserve ownership

Regarding the first elephant, scalability, Bitcoin urgently needs to grow its Blockchain dynamics into something that is living and manageable. To that end, Vukolić refers to a transaction bookkeeping mechanism that works as a “fabric”. That is, it does not require every miner to access the history-of-the-world and append each transaction onto the same chain in serial fashion. Rather than growing an ever bigger blockchain—with ever bigger computers—we need a more 3D approach that uses relational databases in a multi-threaded, transactional environment, while still preserving the distributed, p2p trust mechanisms of the original blockchain.

While clearly technical, it is a good read, even for lay enthusiasts. It directly relates to one of the elephants in the room.

I have pasted Marko’s Abstract below. The full paper is 10½ pages (14 with references).

Bitcoin cryptocurrency demonstrated the utility of global consensus across thousands of nodes, changing the world of digital transactions forever. In the early days of Bitcoin, the performance of its probabilistic proof-of-work (PoW) based consensus fabric, also known as blockchain, was not a major issue. Bitcoin became a success story, despite its consensus latencies on the order of an hour and the theoretical peak throughput of only up to 7 transactions per second.

The situation today is radically different and the poor performance scalability of early PoW blockchains no longer makes sense. Specifically, the trend of modern cryptocurrency platforms, such as Ethereum, is to support execution of arbitrary distributed applications on blockchain fabric, needing much better performance. This approach, however, makes cryptocurrency platforms step away from their original purpose and enter the domain of database-replication protocols, notably, the classical state-machine replication, and in particular its Byzantine fault-tolerant (BFT) variants.

In this paper, we contrast PoW-based blockchains to those based on BFT state machine replication, focusing on their scalability limits. We also discuss recent proposals to overcoming these scalability limits and outline key outstanding open problems in the quest for the “ultimate” blockchain fabric(s). Keywords: Bitcoin, blockchain, Byzantine fault tolerance, consensus, proof-of-work, scalability, state machine replication

* Like Marko, Blockchains, Cloud computing, and Privacy are, also my primary reserach interests, (GMTA!). But, I cede the rigorous, academic credentials to Marko.

† BFT = Byzantine Fault Tolerant consensus protocols

Related—and recently in the news:

Raymond co-chairs CRYPSA and The Bitcoin Event. A columnist & board member at Lifeboat Foundation
he edits AWildDuck. He will deliver the keynote address at Digital Currency Summit in Johannesburg.

RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio-visual journey, diving into a cell to show how genes are transcribed to make messenger RNA (mRNA) and how RNAi can silence specific mRNAs to stop them from making proteins. The animation is based on the latest research, to give you an up-to-date view.

If you’d like to know more about the structures and processes you see in this video, check out the accompanying slideshow: http://www.nature.com/nrg/multimedia/rnai/animation/index.html

Sponsor message (May 2014): Dharmacon RNAi products are now part of GE Healthcare.

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Recent evidence suggests that a variety of organisms may harness some of the unique features of quantum mechanics to gain a biological advantage. These features go beyond trivial quantum effects and may include harnessing quantum coherence on physiologically important timescales.

Quantum Biology — Quantum Mind Theory

IBM researchers have established experimental proof of a previously difficult-to-prove law of physics, and in so doing may have pointed to a way to overcome many of the heat management issues faced in today’s electronics. Researchers at IBM Zurich have been able to take measurements of the thermal conductance of metallic quantum point contacts made of gold. No big deal, you say? They conducted measurements at the single-atom level, at room temperature—the first time that’s ever been done.

These measurements confirm the Wiedemann–Franz law, which predicts that the smallest amount of heat that can be carried across a metallic junction — a single quantum of heat — is directly proportional to the quantum of electrical conductance through the same junction. By experimentally confirming this law, it can now be used with confidence to predict and to explore nanoscale thermal and electrical phenomena affecting materials down to the size of few atoms or a single molecule.

“Although the Wiedemann–Franz law is predicted, and should be valid for certain metals, it has turned out to be difficult to prove it when you go to the nanoscale,” explained Bernd Gotsmann, an IBM scientist and one of the lead researchers on this work, in an e-mail interview with IEEE Spectrum. “We think the difficulty is mainly a sign of the challenges related to the measurement of thermal transport on small scales.”

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