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Development and Validation of a Simple and Cost-Effective LC-MS/MS Method for the Quantitation of the Gut-Derived Metabolite Trimethylamine N-Oxide in Human Plasma of Healthy and Hyperlipidemic Volunteers

Trimethylamine N-oxide (TMAO) is a gut microbial metabolite of dietary precursors, including choline and carnitine. Elevated levels of TMAO in human plasma have been associated with several diseases such as cardiovascular, diabetes mellitus, chronic kidney disease, neurological disorders, and cancer. This has led to an increased interest in the accurate determination of TMAO in human blood, for which a reliable, cost-effective and sensitive analytical method should be established. LC-MS/MS has emerged as a powerful tool for the determination of TMAO due to its high sensitivity, specificity, and ability to handle complex matrices. Herein, we describe the development and validation of an LC-MS/MS method for the determination of TMAO in human blood plasma.

Breakthrough battery lets physicists reverse entanglement—and rewrite quantum law

Scientists have finally uncovered a quantum counterpart to Carnot’s famed second law, showing that entanglement—once thought stubbornly irreversible—can be shuffled back and forth without loss if you plug in a clever “entanglement battery.”

Psilocybin treatment extends cellular lifespan and improves survival of aged mice

Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent.

Kato, K., Kleinhenz, J.M., Shin, YJ. et al. Psilocybin treatment extends cellular lifespan and improves survival of aged mice. npj Aging 11, 55 (2025). https://doi.org/10.1038/s41514-025-00244-x.

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Devices that pull water out of thin air poised to take off

More than 2 billion people worldwide lack access to clean drinking water, with global warming and competing demands from farms and industry expected to worsen shortages. But the skies may soon provide relief, not in the form of rain but humidity, sucked out of the air by “atmospheric water harvesters.” The devices have existed for decades but typically are too expensive, energy-hungry, or unproductive to be practical.

Now, however, two classes of materials called hydrogels and metal-organic frameworks have touched off what Evelyn Wang, a mechanical engineer at the Massachusetts Institute of Technology (MIT), calls “an explosion of efforts related to atmospheric water harvesting.”

So far, none of the devices can compete with established approaches to augment water supplies, such as desalinating seawater. But some applications—cooling data centers and slaking the thirst of soldiers on the move—could support higher costs until the technology scales up, says Samer Taha, CEO of Atoco, a California-based startup. “There are many applications where atmospheric water harvesting can help.”