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CRISPR-Based Screen Reveals Possible Anti-Tau Mechanism
This screening platform washed cells with a broad range of retroviruses to determine which ones affect tau. In follow-up testing, the gene CUL5 was singled out as being crucial for tau degradation. Mitochondrial function was also found to be a key part of preventing tau pathology.
Using an ingenious CRISPR-based screening technique, scientists have found a protein that tags tau for degradation and is more strongly expressed in tau-resilient neurons [1].
Some neurons are more equal than others
The accumulation of tau protein fibrils in neurons is a hallmark of Alzheimer’s and several other diseases [2]. Scientists have long noticed that even in the brains of people who died of Alzheimer’s, some neurons are markedly healthier than others, suggesting that neurons differ in how they handle tau and that these differences may explain selective vulnerability in tauopathies [3].
Vehique: Hi!
I’m Gemechu. I’m a software engineer and AI builder finishing my Master’s in CS at LMU Los Angeles this May.
I’m looking to join a team, full-time or internship!
For context, I have hands-on experience shipping AI-powered products to production. I recently built https://www.vehique.ai/, a conversational vehicle marketplace from scratch — designed the multi-agent architecture, built the full stack, and scaled it to over 3,000 monthly users. Prior to that I have a couple of research engineering experiences at seed-stage startups.
Have experience building end to end, whether that’s the AI layer, backend and infra, or full-stack product work.
Looking to join where I can create impactful products.
If you’re hiring or know someone who might be, please feel free to reach out.
🌿 All my projects and experience are on my portfolio — https://gemechu.xyz/
Enterprise Spotlight: Manufacturing Reimagined
Emerging technologies from AI and extended reality to edge computing, digital twins, and more are driving big changes in the manufacturing world.
Download the February 2026 issue of the Enterprise Spotlight from the editors of CIO, Computerworld, CSO, InfoWorld, and Network World and learn about the new tech at the forefront of innovation and how it is poised to reshape how companies operate, compete, and deliver value in a rapidly evolving digital landscape.
Epistasis study uncovers genetic interactions linked to heart disease
Euan Ashley’s lab explores the intricate interactions of gene variants. Tiny “typos,” or genetic mutations, can sneak into segments of DNA. Many of these are harmless, but some can cause health problems. Two or more genes can team up and change the outcome of a physical or molecular trait. This phenomenon, known as epistasis, occurs through complex interactions between genes that are functionally related—such as those that support protein creation.
Identifying these group dynamics provides crucial clues to how genetic diseases manifest and should be treated. But they’re not easily detected and often fly under the radar.
To help root out these connections, Ashley, MB ChB, DPhil, professor of genetics and of biomedical data science, and a team of scientists, including co-corresponding author Bin Yu, Ph.D., a professor of statistics and of electrical engineering and computer sciences at the University of California, Berkeley, have developed computational techniques to identify and understand the hidden ways epistasis influences inherited diseases.
I Put Music Theory in a Leaf
Support me on Patreon:https://www.patreon.com/LeviMcClainConnect with me here:Levi McClain’s Music: https://linktr.ee/levimcclainmusicLevi McClain’s Instagra…