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Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques

Antler blastema progenitor cells (ABPCs) are a distinct population of skeletal mesenchymal stem cells found in regenerating deer antlers, with strong stemness and renewal capacity in vitro. Stem cell-derived extracellular vesicles (EVs) are emerging as potential therapeutic candidates that can mediate donor cells’ beneficial effects. Here, we tested the effects of ABPC-derived EVs (EVsABPC) on aging in mice and rhesus macaques (Macaca mulatta). We identified a variety of unique factors in EVsABPC and showed that in vitro, EVsABPC attenuated phenotypes of senescence in bone marrow stem cells. In aged mice and macaques, EVsABPC substantially increased femoral bone mineral density. Further, intravenous EVsABPC improved physical performance, enhanced cognitive function and reduced systemic inflammation in aged mice, while reversing epigenetic age by over 3 months. In macaques, EVABPC treatment was also neuroprotective, reduced inflammation, improved locomotor function and reduced epigenetic age by over 2 years. Our findings position ABPCs as an emerging and practical source of EVs with translational value for healthy aging interventions.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

Hunting for quantum-classical crossover in condensed matter problems

The intensive pursuit for quantum advantage in terms of computational complexity has further led to a modernized crucial question of when and how will quantum computers outperform classical computers. The next milestone is undoubtedly the realization of quantum acceleration in practical problems. Here we provide a clear evidence and arguments that the primary target is likely to be condensed matter physics. Our primary contributions are summarized as follows: 1) Proposal of systematic error/runtime analysis on state-of-the-art classical algorithm based on tensor networks; 2) Dedicated and high-resolution analysis on quantum resource performed at the level of executable logical instructions; 3) Clarification of quantum-classical crosspoint for ground-state simulation to be within runtime of hours using only a few hundreds of thousand physical qubits for 2d Heisenberg and 2d Fermi-Hubbard models, assuming that logical qubits are encoded via the surface code with the physical error rate of p = 10–3. To our knowledge, we argue that condensed matter problems offer the earliest platform for demonstration of practical quantum advantage that is order-of-magnitude more feasible than ever known candidates, in terms of both qubit counts and total runtime.

Yoshioka, N., Okubo, T., Suzuki, Y. et al. Hunting for quantum-classical crossover in condensed matter problems. npj Quantum Inf 10, 45 (2024). https://doi.org/10.1038/s41534-024-00839-4

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Subaru telescope uncovers ancient ‘fossil’ object in outer Solar System

Far beyond Pluto, icy wanderers known as Trans-Neptunian Objects (TNOs) drift through the vast cosmic depths. Some of them orbit at incredible distances, more than 200 times farther from the Sun than Earth, making them tough to spot, but priceless to study.

These elusive objects may hold secrets to how the Solar System formed, and even hint at the presence of a mysterious Planet Nine lurking in the shadows.

Now, the Subaru Telescope has spotted a new one: a small, distant body that’s helping scientists piece together the puzzle of our solar neighborhood’s past and its still-unfolding future.

Netflix’s ‘The Eternaut’ Pioneers Generative AI for 10x Faster VFX, Sparking Hollywood Job Debates

Netflix’s “The Eternaut,” an Argentine sci-fi series, pioneers generative AI for a building collapse scene, enabling 10x faster VFX and cost savings. Co-CEO Ted Sarandos sees it empowering creators, not replacing them. Mixed reactions highlight job fears, signaling AI’s growing role in Hollywood amid ethical debate.

This Stem Cell Treatment Could One Day Make Insulin Obsolete

Type I diabetes is an exhausting full-time job. Having it means living a life full of constant care and maintenance. You’re always checking in on your blood sugar to make sure it isn’t too high or is it too low, extremes that could be easily reached with the most minor indulgence or tiniest bout of laziness.

A new treatment, as detailed in the New York Times, might change everything we know about managing type I diabetes.

Zimislecel is an experimental stem cell-based therapy that recently dropped a bomb on the diabetes world. Developed by the Boston-based Vertex Pharmaceuticals, it’s a one-time infusion that has turned 10 of 12 trial patients suffering from severe type I diabetes into people who no longer need insulin, and in less than a year.

Topological quantum processor marks breakthrough in computing

In a leap forward for quantum computing, a Microsoft team led by UC Santa Barbara physicists on Wednesday unveiled an eight-qubit topological quantum processor, the first of its kind. The chip, built as a proof-of-concept for the scientists’ design, opens the door to the development of the long-awaited topological quantum computer.

“We’ve got a bunch of stuff that we’ve been keeping under wraps that we’re dropping all at once now,” said Microsoft Station Q Director Chetan Nayak, a professor of physics at UCSB and a Technical Fellow for Quantum Hardware at Microsoft. The chip was revealed at Station Q’s annual conference in Santa Barbara, and accompanies a paper published in the journal Nature, authored by Station Q, their Microsoft teammates and a host of collaborators that presents the research team’s measurements of these new qubits. (Circa Feb 20 2025)

Microsoft team led by UC Santa Barbara physicists unveils first-of-its-kind topological qubit, paving the way for a more fault-tolerant quantum computer.