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New treatment eliminates bladder cancer in 82% of patients

LOS ANGELES — A new drug-releasing system, TAR-200, eliminated tumors in 82% of patients in a phase 2 clinical trial for individuals with high-risk non-muscle-invasive bladder cancer whose cancer had previously resisted treatment.

In the majority of cases, the cancer disappeared after only three months of treatment, and almost half the patients were cancer-free a year later.

“Traditionally, these patients have had very limited treatment options. This new therapy is the most effective one reported to date for the most common form of bladder cancer,” said Sia Daneshmand, MD, director of urologic oncology with Keck Medicine of USC and lead author of a study detailing the clinical trial results published in the Journal of Clinical Oncology. “The findings of the clinical trial are a breakthrough in how certain types of bladder cancer might be treated, leading to improved outcomes and saved lives.”#

Rogue Planets Floating in Space Appear to Be Forming Their Own Moons

Free-floating, planetary-mass objects that are just drifting carefree through the galaxy, untethered and starless, appear to be able to generate their own systems of moons, like a planetary system on a miniature scale.

An analysis of new JWST observations on a number of rogue planets – each weighing between five and 10 Jupiters – has revealed the presence of disks with a significant proportion of crystalline silicate, just like those surrounding some baby stars right before their planets start to form.

“These studies show that objects with masses comparable to those of giant planets have the potential to form their own miniature planetary systems,” says observational astronomer Aleks Scholz of the University of St Andrews in the UK.

Brain Autopsies Revealed a Potential Culprit Behind Alzheimer’s

Scientists have revealed that immune cells in Alzheimer’s brains behave differently from those in brains of people without the disease – a discovery that could lead to new treatments.

Published in 2023, an analysis of human brain tissue discovered microglia in the brains of people with Alzheimer’s were more frequently in a pre-inflammatory state, making them less likely to be protective.

Microglia are immune cells that help keep our brains healthy by clearing waste and preserving normal brain function.

Scientists just found a protein that reverses brain aging

Scientists at UCSF have uncovered a surprising culprit behind brain aging: a protein called FTL1. In mice, too much FTL1 caused memory loss, weaker brain connections, and sluggish cells. But when researchers blocked it, the animals regained youthful brain function and sharp memory. The discovery suggests that one protein could be the master switch for aging in the brain — and targeting it may one day allow us to actually reverse cognitive decline, not just slow it down.

Magnetically induced convection enhances water electrolysis in microgravity

Electrochemical devices producing oxygen in space face limited buoyancy, hindering gas bubble removal and increasing reaction overpotentials. Now, it has been shown that commercial magnets can enhance the reaction efficiency and induce phase separation in microgravity. The optimized magnetoelectrochemical architectures developed here may guide the designs of future life-support systems.

Mysterious Object Hurtling Toward Us From Beyond Solar System Appears to Be Emitting Its Own Light, Scientists Find

The object, dubbed 3I/ATLAS, has caught the attention of Harvard astronomer Avi Loeb, who has a long track record of making controversial predictions about previous interstellar objects being relics from an extraterrestrial civilization.

While there’s been a growing consensus among astronomers that the latest object is a comet, Loeb has continued to entertain the idea that it may have been sent to us by an intelligent species from outside of the solar system — and he’s far from backing down.

In a blog post over the weekend, Loeb pointed to observations by NASA’s Hubble Space Telescope, which showed a “glow of light, likely from a coma, ahead of the motion of 3I/ATLAS towards the Sun.”

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