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Central sensitization: analysis by physio meets science.

Neurophysiological Mechanism of Central Sensitization in the Spinal Cord following Surgery:

▶️ Central sensitization was first described by Woolf in 1983 (https://pubmed.ncbi.nlm.nih.gov/6656869/) as a form of long-term adaptive neuroplasticity that amplifies the transmission of nociceptive information by affecting spinal cord neurons and is believed to be a principal neurophysiological mechanism with regard to pain persistence.

▶️ Peripheral nociception can trigger a prolonged increase in the excitability of dorsal root ganglia (DRG) neurons, which transmit nociceptive signals to the spinal cord, resulting in central sensitization.

▶️ This condition involves heightened responsiveness of spinal neurons, driven by signaling molecules like adenosine triphosphate (ATP) and neurotransmitters such as glutamate (Glu) and substance P (SP).

▶️ These molecules activate specific receptors on spinal neurons, including purinergic receptor 2 (P2-R), N-methyl-D-aspartate receptor (NMDAR), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), and neurokinin 1 receptor (NK1R).

▶️ The activation of these receptors sets off a cascade of intracellular pathways involving enzymes like calcium/calmodulin-dependent protein kinase II (CaMKII), protein kinase C (PKC), protein kinase A (PKA), mechanistic target of rapamycin (mTOR), phosphoinositide 3-kinase (PI3K), and extracellular signal-regulated kinases 1/2 (ERK1/2), all of which amplify the transmission of nociceptive signals to the brain.

Continue reading “Mechanisms of chronic postsurgical pain” | >

I’ve long been fascinated by the fundamental mystery of our universe’s origin. In my work, I explore an alternative to the traditional singularity-based models of cosmology. Instead of a universe emerging from an infinitely dense point, I propose that a flat universe and its time-reversed partner—an anti-universe—can emerge together from nothing through a smooth, quantum process.

This model, described in a manuscript accepted for publication in Europhysics Letters, addresses some of the key challenges in earlier proposals, such as the Hartle–Hawking no-boundary and Vilenkin’s tunneling approaches.

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Key Takeaways A study found that some organs age faster than a person’s actual ageFaster organ aging is linked to diseases like cancer, dementia and heart diseaseA blood test could help detect early signs of organ aging.

MONDAY, March 17, 2025 (HealthDay News) — Your organs might be aging faster than you are — and that could increase your risk for serious diseases, including cancer, heart disease and dementia.

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Researchers at Heriot-Watt University have made a discovery that could pave the way for a transformative era in photonic technology. For decades, scientists have theorized the possibility of manipulating the optical properties of light by adding a new dimension—time. This once-elusive concept has now become a reality thanks to nanophotonics experts from the School of Engineering and Physical Sciences in Edinburgh, Scotland.

Published in Nature Photonics, the team’s breakthrough emerged from experiments with nanomaterials known as transparent conducting oxides (TCOs)—a special glass capable of changing how light moves through the material at incredible speeds. These compounds are widely found in and touchscreens and can be shaped as ultra-thin films measuring just 250 nanometers (0.00025 mm), smaller than the wavelength of visible light.

Led by Dr. Marcello Ferrera, Associate Professor of Nanophotonics, of the Heriot-Watt research team, supported by colleagues from Purdue University in the US, managed to “sculpt” the way TCOs react by radiating the material with ultra-fast pulses of light. Remarkably, the resulting temporally engineered layer was able to simultaneously control the direction and energy of individual particles of light, known as photons, a functionality which, up until now, had been unachievable.

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A Cornell-led research team has developed an artificial intelligence-powered ring equipped with micro-sonar technology that can continuously—and in real time—track fingerspelling in American Sign Language (ASL).

In its current form, SpellRing could be used to enter text into computers or smartphones via fingerspelling, which is used in ASL to spell out words without corresponding signs, such as proper nouns, names and technical terms. With further development, the device—believed to be the first of its kind—could revolutionize ASL translation by continuously tracking entire signed words and sentences.

The research is published on the arXiv preprint server.

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Korean researchers have succeeded in developing a key technology for all-solid-state secondary batteries, known as next-generation lithium-ion batteries due to their high safety. The work was published online as a cover study in Small at the end of last year.

Electronics and Telecommunications Research Institute (ETRI) developed a separation membrane based on a material that easily becomes fibrillized when subjected to mechanical shearing (force applied) through a mixing process with solid electrolyte powder without using a solvent. This solid electrolyte membrane is simple and fast to manufacture and is extremely thin and robust.

In general, in research on all-solid-state secondary batteries, the thickness is set to several hundred micrometers (µm) to 1 millimeter (mm) to increase the durability of the membrane when using a hard solid electrolyte in the manufacturing process. However, this has the disadvantage of being too thick compared to conventional polymer separation membranes, resulting in a very large loss of energy density.

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It may someday be possible to listen to a favorite podcast or song without disturbing the people around you, even without wearing headphones. In a new advancement in audio engineering, a team of researchers led by Yun Jing, professor of acoustics in the Penn State College of Engineering, has precisely narrowed where sound is perceived by creating localized pockets of sound zones, called audible enclaves.

In an enclave, a listener can hear sound, while others standing nearby cannot, even if the people are in an enclosed space, like a vehicle, or standing directly in front of the audio source.

In a study published in the Proceedings of the National Academy of Sciences, the researchers explain how emitting two nonlinear ultrasonic beams creates audible enclaves, where sound can only be perceived at the precise intersection point of two ultrasonic beams.

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We move thanks to coordination among many skeletal muscle fibers, all twitching and pulling in sync. While some muscles align in one direction, others form intricate patterns, helping parts of the body move in multiple ways.

In recent years, scientists and engineers have looked to muscles as potential actuators for “biohybrid” robots—machines powered by soft, artificially grown . Such bio-bots could squirm and wiggle through spaces where traditional machines cannot. For the most part, however, researchers have only been able to fabricate artificial muscle that pulls in one direction, limiting any robot’s range of motion.

Now MIT engineers have developed a method to grow artificial muscle tissue that twitches and flexes in multiple coordinated directions. As a demonstration, they grew an artificial, muscle-powered structure that pulls both concentrically and radially, much like how the iris in the human eye acts to dilate and constrict the pupil.

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