Jan 27, 2024
Outcomes in Takotsubo Syndrome and Associations with Medication Use
Posted by Shubham Ghosh Roy in category: biotech/medical
Patients with takotsubo syndrome in a new study had elevated cardiovascular and noncardiovascular death rates. Inhibitors of the renin-angiotensin system were the only cardiovascular medications associated with reduced risk.
In takotsubo syndrome (TS) — also called stress cardiomyopathy or broken heart syndrome — long-term mortality is elevated, similar to that after acute myocardial infarction (AMI), but for unclear reasons. Additionally, evidence-based therapies are lacking for TS. To explore causes of death and the effects of heterogeneous therapies for TS, investigators in Scotland compared outcomes between 620 patients with TS, 620 matched patients presenting with AMI, and 2,480 matched individuals from the general population. Median follow-up was 5.5 years.
Among patients with TS, all-cause mortality was higher compared with the general population (hazard ratio, 1.8), both for cardiovascular causes (HR, 2.5) and noncardiovascular causes (HR, 1.5), but was lower compared with patients with AMI (HR, 0.8). Patients with TS were prescribed cardiovascular and noncardiovascular medications at similar rates to those with AMI. Use of diuretics, anti-inflammatory agents, and psychotropic agents were associated with higher mortality in patients with TS, as was chronic anti-inflammatory medication use. The only medications associated with lower mortality in patients with TS were inhibitors of the renin-angiotensin system.
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