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We are happy to announce Dr. Nir Barzilai, Albert Einstein College of Medicine, as a speaker for the 2019 Undoing Aging Conference

Dr. Barzilai is a chaired Professor of Medicine and Genetics and Director of the biggest Center in the world to study the Biology of Aging.

“Nir is our keynote speaker this year because, quite honestly, if I’d only given him half an hour there is no way he could do justice to his role in our movement. His scientific contributions have been world-leading for decades, but in recent years he has done so much more: he has taken a prominent role in two important rejuvenation startups, and he has also employed his exceptional political skills in forging invaluable new understandings between the biomedical gerontology and regulatory communities. Plus, he’s almost as entertaining a speaker as me!”, says Aubrey de Grey.

Yaron Fuchs Awarded Sartorius & Science Prize

Yaron Fuchs is the 2018 grand prize winner of the Sartorius & Science Prize for Regenerative Medicine & Cell Therapy, for work that reveals a role for programmed stem cell death in wound healing and tissue regeneration. The findings, described in his prize-winning essay, “The therapeutic promise of apoptosis,” could potentially pave the way to novel regenerative medicine and tumor therapies that target stem cells undergoing apoptosis — a type of programmed cell death.

The 2018 grand prize winner revealed a role for programmed stem cell death in wound healing and tissue regeneration, and potentially in tumor therapies.

Anti-Aging Research: Science, not Hype

You’re cordially invited to the 1st of a series of blog entries I’m writing on anti-aging research smile

A: “It’s a dynamic system that veers away from its homeostasis (normal equilibrium point): hence a form of slow-progressing illness. Labeling it as ‘natural’ is a surrender to our traditional state of ignorance and powerlessness, which fortunately are beginning to be changed!”

THE AOA PROBLEM – WHAT WE CAN DO ABOUT IT (reprinted from Curt Lewis Flight Safety Information News)

In the wake of the October 29 Indonesian crash of a brand new Boeing 737 MAX 8 that took the lives of 189 passengers, the FAA has issued Emergency Airworthiness Directive (AD) 2018−23−51. The 737 is the most widely flown aircraft in the world, This tragedy opens an important conversation between regulators, operators and pilots.

Lion Air, an experienced 737 operator, was the launch carrier last year for the 737 MAX 8 and the MAX 9 in March. While it will take a long time to analyze the Lion Air 610 accident, the AD points out that current system architecture has created vulnerabilities.

APOE Gene Therapy In Clinical Trials To Prevent Alzheimer’s

The APOE gene, or the “forgetting gene,” has been proven to influence Alzheimer’s risk. So a team of scientists is exploring the effect of gene therapy on people with the riskiest version of the gene.

If it works, the pay-off could be huge.

Gene therapy involves transplanting specific genetic material into human cells in order to correct genetic problems, and is typically attempted on diseases with a singular cause. Alzheimer’s doesn’t seem to have one singular cause — but since the risk of developing it is so strongly associated with the APOE gene, it’s certainly worth a try.

Juvenescence: Investing in the age of longevity

In the spirit of the progenitor of Budda, Mohammed, and Christ, accept that the purse is a tool of suffering.

This new book by Jim Mellon and Al Chalabi is a layman’s guide to longevity. It investigates the new technologies and explains how to benefit from the life extending technologies both personally and professionally. It helps readers unravel the science, offers ideas on potential investment and reveals the views of the key opinion leaders.

Immune Function as a Determinant of Aging and Longevity

The state of the immune system is an important determinant of aging. With age, immune function both declines in effectiveness and becomes inflammatory. Chronic inflammation accelerates the progression of all of the common age-related diseases. It disrupts tissue maintenance and regeneration, to pick one of many examples. It is likely that a sizable component of variation in aging arises from the differences between individuals in the degree to which the immune system has become damaged and dysfunctional.

Some of this immune aging is a matter of the burden of exposure to more rather than fewer pathogens over a lifetime: persistent infections in particular, such as cytomegalovirus and other herpesviruses, appear to drive immune aging. Some immune aging stems from the atrophy of the thymus, the organ responsible for maturation of T cells. A lesser volume of active thymic tissue means fewer new T cells to take up an effective defense of the body. Some immune aging is due to failure of barriers in the gut, allowing gut bacteria to trigger inflammatory activity. Some immune aging arises from cellular senescence among immune cells, turning them into harmful centers of inflammatory signaling. All of these issues have potential solutions, but, as in all matters related to aging, far too little funding and attention are given to the relevant development programs.

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