Lifeboat Foundation

Senescent cell removal is the first true rejuvenation therapy to treat one of the aging processes and with human clinicial trials in the next 18 months these are some very exciting times. Here is yet another study showing natural compounds can be used in combination with drugs to kill senescent cells.

Today’s open access research paper outlines the discovery of yet another new candidate drug for the selective destruction of senescent cells. This is an increasingly popular research topic nowadays. Senescent cells perform a variety of functions, but on the whole they are bad news. Cells become senescent in response to stresses or reaching the Hayflick limit to replication. They cease further division and start to generate a potent mix of signals, the senescence-associated secretory phenotype or SASP, that can provoke inflammation, disarray the surrounding extracellular matrix structures, and change behavior of nearby cells for the worse. Then they destroy themselves, or are destroyed by the immune system — for the most part at least. This is helpful in wound healing, and in small doses helps to reduce cancer incidence by removing those cells most at risk of becoming cancerous. Unfortunately a growing number of these cells linger without being destroyed, more with every passing year, and their presence eventually causes significant dysfunction. That in turn produces age-related disease, frailty, and eventually death. Senescent cells are not the only root cause of aging, but they provide a significant contribution to the downward spiral of health and wellbeing, and even only their own would eventually produce death by aging.

The beneficial aspects of senescent cells seem to require only a transient presence, so the most direct approach to the problem presented by these cells is to destroy them every so often. Build a targeted therapy capable of sweeping senenscent cells from tissues, and make it efficient enough to keep the count of such cells low. That is the way to prevent senescent cells form contributing to age-related disease. Working in mice, researchers have produced results such as functional rejuvenation in aged lungs and extended life span through the targeted destruction of senescent cells. Since perhaps only a few percent of the cells in old tissue are senescent, this targeted destruction can be accomplished with few side-effects beyond those generated by off-target effects of the medication itself.

Continue reading “Piperlongumine as a Senolytic Drug Candidate with Fewer Side-Effects” »

A new biomarker for Alzheimers could improve the patient outcome and allow for earlier treatment.

An enzyme found in the fluid around the brain and spine is giving researchers a snapshot of what happens inside the minds of Alzheimer’s patients and how that relates to cognitive decline.

Iowa State University researchers say higher levels of the enzyme, autotaxin, significantly predict memory impairment and Type 2 diabetes. Just a one-point difference in autotaxin levels — for example, going from a level of two to a three — is equal to a 3.5 to 5 times increase in the odds of being diagnosed with some form of memory loss, said Auriel Willette, an assistant professor of food science and human nutrition at Iowa State.

Continue reading “New biomarker predicts Alzheimer’s disease and link to diabetes” »

Designing synthetic promoters for safe and precise targeting of dysfunctional “senescent” cells, with the aim of developing senolytic gene therapies to remove them.

Even in the best case, automation leaves the first generation of workers it displaces in a lurch because they usually don’t have the skills to do new and more complex tasks, Mr. Acemoglu found in a paper published in May.

Robert Stilwell, 35, of Evansville, Ind., is one of them. He did not graduate from high school and worked in factories building parts for tools and cars, wrapping them up and loading them onto trucks. After he was laid off, he got a job as a convenience store cashier, which pays a lot less.

“I used to have a really good job, and I liked the people I worked with — until it got overtaken by a machine, and then I was let go,” he said.

Continue reading “The Long-Term Jobs Killer Is Not China. It’s Automation” »

The first pioneers on Mars may build their homes using the ice beneath their feet.

In November, a University of Texas research team reported that Mars’ Utopia Planitia region contains about as much water, in the form of buried ice, as Lake Superior does here on Earth.

This ice layer, which spans a greater area than the state of New Mexico, lies in Mars’ mid-northern latitudes and is covered by just 3 feet to 33 feet (1 to 10 meters) of soil, the scientists determined. [Photos: The Search for Water on Mars].

Dr. Chen Yue, Director of Commercial Satellite Technology for the China Academy of Space Technology (CAST) announced on December 10, 2016 that not only has China successfully tested EmDrives technology in its laboratories, but that a proof-of-concept is currently undergoing zero-g testing in orbit (according to the International Business Times, this test is taking place on the Tiangong 2 space station).

Scientists with the China Academy of Space Technology claim NASA’s results ‘re-confirm’ what they’d already achieved, and have plans to implement it in satellites ‘as quickly as possible.’

Continue reading “China says tests of Propellentless EMDrive on Tiangong 2 space station were successful” »

My solution for air pollution. What do u think?

Solve CoLab is a forum in which individuals and groups collaborate on solutions to global challenges.

ExoMars will soon start aerobraking in Mars orbit in a years-long effort to sample Mars super-thin lower atmosphere in the ongoing search for trace gases indicative of life and active geology.

ESA’s ExoMars Trace Gas Orbiter is preparing to aerobrake into parts of the unexplored Martian lower atmosphere in search of methane, water vapor and other possible signatures of life on the Red Planet.

New study provides deeper insight into the immune system.

In a bid to better understand the gene expression patterns that control T cell activity, researchers at the La Jolla Institute for Allergy and Immunology mapped genome-wide changes in chromatin accessibility as T cells respond to acute and chronic virus infections. Their findings, published in the Dec. 20, 2016 issue of Immunity, shed light on the molecular mechanisms that determine the fate of T lymphocytes and open new approaches to clinical intervention strategies to modulate T cell activity and improve immune function.

“Identifying the different factors that determine different T cell states and therefore their function helps us understand if T cells will be able or not to fight viral infections or tumor growth, and if they will be able or not to provide long-term protection,” says the study’s first author James Scott-Browne, a postdoctoral fellow in the laboratory of Anjana Rao, a professor in the Division of Signaling and Gene Expression. “We may be able to revert the exhaustion phenotype of T cells and render them better able to fight tumors or chronic viral infections such as HIV, or generate better memory cells in response to vaccines.”

Continue reading “Researchers map genome-wide changes that drive T cell maturation and exhaustion” »