Lifeboat Foundation

When Brian Hanley set out to test a gene therapy, he started with himself.

The microglia are central to aging in the brain and science is already finding ways to reverse it like introducing young microglia to the brain to remove plaques associated with Alzheimers. Brain aging is not a one way process!

The difference between an old brain and a young brain isn’t so much the number of neurons but the presence and function of supporting cells called glia. In Cell Reports on January 10, researchers who examined postmortem brain samples from 480 individuals ranging in age from 16 to 106 found that the state of someone’s glia is so consistent through the years that it can be used to predict someone’s age. The work lays the foundation to better understand glia’s role in late-in-life brain disease.

“We extensively characterized aging-altered gene expression changes across 10 human brain regions and found that, in fact, glial cells experience bigger changes than neurons,” says Jernej Ule, a neurobiologist at the Francis Crick Institute and the University College London, who led the study with departmental colleague Rickie Patani (@PataniLab) and first author Lilach Soreq. “There’s quite a bit of regional information that will be of interest to different people—for example some will notice a very unique pattern of astrocyte-specific changes in the substantia nigra—and we provide a lot of data that still needs to be analyzed.”

Continue reading “Glia, not neurons, are most affected by brain aging” »

Playing God is a common objection to developing technologies to increase human lifespan and yet it is never used in relation to current therapies already available.

Here I’ll point out another of the articles going up at the Life Extension Advocacy Foundation, this time on the topic of the naturalistic fallacy where it occurs in opposition to healthy life extension. Our community would like to build medical therapies that address the causes of aging, thereby ending age-related disease and greatly extending healthy human life spans. It has always surprised me to find that most people, at least initially, object to this goal. It seems perfectly and straightforwardly obvious to me that aging to death, suffering considerably along the way, is just as much a problem to be overcome as any other medical condition that causes pain and mortality. Yet opposition exists, and that opposition is one of the greatest challenges faced when raising funding and pushing forward with research and development of rejuvenation therapies.

When it comes to treating aging as a medical condition the naturalistic fallacy is voiced in this way: aging is natural, what is natural is good, and therefore we shouldn’t tamper with aging. If you look around at your houses, your computers, your modern medicine, and consider that such an objection is perhaps just a little late to the game, and hard to hold in a self-consistent manner, then you’re probably not alone. Notably, the same objection is rarely brought up when it comes to treating specific age-related diseases, or in the matter of therapies that already exist. People who are uncomfortable about radical changes to the course of aging and who speak out against the extension of human life are nonetheless almost all in favor of cancer research, treatments for heart disease, and an end to Alzheimer’s disease. Yet age-related diseases and aging are the same thing, the same forms of damage and dysfunction, only differing by degree and by the names they are given.

Continue reading “Addressing Naturalistic Objections to Extending Healthy Human Life Spans” »

The Cellage synthetic biology digest.

The field of synthetic biology holds the potential to treat a variety of aging processes and treat age-related diseases. Synthetic biology allows biologists to create new functions in cells by creating synthetic cellular programs and could allow us to combat age-related diseases in ways never before considered.

#aging #crowdfundthecure

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https://www.consumerphysics.com/myscio/

Want to take someone’s site down and need a cheap hacker; well the Dark Web has them.

In the lawless digital hinterlands of the dark web, hackers hire out their expertise for just £20, offering to cripple websites with an overload of data from ready-made “botnet” armies.

On hidden forums, accessible only by using encrypted technology, clients tout for their services, bidding to have cybercriminals perform all manner of illegal activities, such as compromising university systems to alter grades.

Continue reading “Cybercriminals charge just £20 to paralyse websites” »

Meet TOR the Dark Web’s friend. It does many of the same capabilities like a Google except your IP address is hidden. There are rules about using the site that a person signing up must agree to such as not going to sights that bogs down the performance, etc.

Ever wondered how cyber criminals meet online. How do they conduct their meetings and operations? Is it anyway near your Hollywood fantasy? Check this post to know about various anonymous platforms of hacker dealings!

It seems the dark web is now making it easier for disgruntled employees to take their revenge to the next level, we learn from the KrebsOnSecurity article, “Rise of Darknet Stokes Fear of the Insider.” The article cites Gartner analyst Avivah Litan; she reports a steep increase in calls from clients concerned about vindictive employees, current or former, who might expose sensitive information on the dark web. Not surprisingly, companies with a lot of intellectual property at stake are already working with law-enforcement or private security firms to guard against the threat.

How, exactly, is the dark web making worker retaliation easier than ever before? Writer Brian Krebs explains:

Noam Jolles, a senior intelligence expert at Diskin Advanced Technologies, studies darknet communities. I interviewed her last year in ‘Bidding for Breaches,’ a story about a secretive darknet forum called Enigma where members could be hired to launch targeted phishing attacks at companies. Some Enigma members routinely solicited bids regarding names of people at targeted corporations that could serve as insiders, as well as lists of people who might be susceptible to being recruited or extorted.

His vision is definitely achievable.

The future of airport transfer—in a pod.

World-renowned global futurist Dr. James Canton envisions hotel experiences that include supersonic travel and DNA-driven spa treatments, so what can we expect in the next decade? Canton, a former Apple Computer executive, author and social scientist, worked in conjunction with Hotels.com, to present the Hotels of the Future Study at a recent conference in San Francisco. In the study he describes hotels with everything from RoboButlers and virtual reality entertainment to hotel restaurants based on gourmet genomics and the emergence of neurotechnology to make sleep more refreshing. Canton, who has advised three White House Administrations and over 100 companies, believes these megatrends will shape the future of the hotel experience and that the RoboButler is the change we will most likely see first. Although, he also notes that plans are already underway for a supersonic hyperloop route from Los Angeles to New York City.

Continue reading “A World-Renowned Futurist Reveals The Hotel Of The Future” »