New extensive study shares recent discoveries and sheds light on the role of telomere length in human diseases and aging. Part 3 of 3.
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In 1996, Dolly the sheep became the first mammal to be cloned from a somatic cell. Twenty years later, scientists have succeeded in using the same technique on primates—as detailed in a study published today in the journal Cell, two long-tailed macaque monkeys were born at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai.
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How To Launch A Space Startup
Posted in policy, space travel
In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.
In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.
Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), a novel co-inhibitory receptor, was upregulated in CD8 + T cells of elderly adults. Aged TIGIT + CD8 + T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by TIGIT knockdown.
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for the 2017 tallinn architecture biennale, noumena has presented its installation based on the future of robots and its adaptability with the environment. deep learning has paved the way for machines to expand beyond narrow capabilities to soon achieving human-level performance on intellectual tasks. however, as artificial intelligence — A.I. — establishes its place within humans, society will need to develop a framework for both to thrive. a new form of artificial life will emerge, finding space at the peripheries of humanity in order to not compete for human-dominated resources. A.I. will attempt to improve its operating surroundings to not just survive but be self-sustaining, forming the basis of a civilization constrained at the intersection of nature and technology.
image © tõnu tunnel.
barcelonian based practice noumena has developed a framework to build this narrative based on the cross disciplinary intersection of computational design, mechanical and electronic design, rapid prototyping interaction and mapping. nowadays, computing tools as well as rapid prototyping machines allow to have a quick practical feedback on design solutions and to iterate experimenting different possibility at the same time giving the chance to choose and custom a functional part.
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