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A study from the UNC School of Medicine showed that the protein NLRP12, known for its anti-inflammatory effects, also protects mice on a high-fat diet against obesity and insulin resistance; it might have a similar effect in humans [1].

Study abstract

In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation and are important for resolving inflammation, but their role in obesity is unknown. We show that obesity in humans correlates with reduced expression of adipose tissue NLRP12. Similarly, Nlrp12/ mice show increased weight gain, adipose deposition, blood glucose, NF-kB/ MAPK activation, and M1-macrophage polarization. Additionally, NLRP12 is required to mitigate HFD-induced inflammasome activation. Co-housing with wild-type animals, antibiotic treatment, or germ-free condition was sufficient to restrain inflammation, obesity, and insulin tolerance in Nlrp12/ mice, implicating the microbiota. HFD-fed Nlrp12/ mice display dysbiosis marked by increased obesity-associated Erysipelotrichaceae, but reduced Lachnospiraceae family and the associated enzymes required for short-chain fatty acid (SCFA) synthesis.

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When designing a robot, key components are the robot’s sensors, which allow it to perceive its environment, and its actuators, the electrical or pneumatic motors that allow the robot to move and interact with its environment.

Consider your hand, which has temperature and pressure sensors, but also muscles as actuators. The omni-skins, as the Science Robotics paper dubs them, combine sensors and actuators, embedding them into an elastic sheet. The robotic skins are moved by pneumatic actuators or memory alloy that can bounce back into shape. If this is then wrapped around a soft, deformable object, moving the skin with the actuators can allow the object to crawl along a surface.

The key to the design here is flexibility: rather than adding chips, sensors, and motors into every household object to turn them into individual automatons, the same skin can be used for many purposes. “We can take the skins and wrap them around one object to perform a task—locomotion, for example—and then take them off and put them on a different object to perform a different task, such as grasping and moving an object,” said Kramer-Bottiglio. “We can then take those same skins off that object and put them on a shirt to make an active wearable device.”

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That conclusion is based on a study that reviewed genetic testing results from 1.45 million individuals and found that nearly 25 percent of “variants of uncertain significance” were subsequently reclassified — sometimes as less likely to be associated with cancer, sometimes as more likely.

The study appears in the Journal of the American Medical Association (JAMA).

When variations from the norm are discovered in a gene, the variants are classified as “benign,” “likely benign,” “variant of uncertain significance,” “likely pathogenic,” or “pathogenic.”

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Certainly, there are those in the movement who espouse the most extreme virtues of transhumanism such as replacing perfectly healthy body parts with artificial limbs. But medical ethicists raise this and other issues as the reason why transhumanism is so dangerous to humans when what is considered acceptable life-enhancement has virtually no checks and balances over who gets a say when we “go too far.” For instance, Kevin Warwick of Coventry University, a cybernetics expert, asked the Guardian, “What is wrong with replacing imperfect bits of your body with artificial parts that will allow you to perform better – or which might allow you to live longer?” while another doctor stated that he would have “no part” in such surgeries. There is, after all, a difference between placing a pacemaker or performing laser eye surgery on the body to prolong human life and lend a greater degree of quality to human life, and that of treating the human body as a tabula rasa upon which to rewrite what is, effectively, the natural course of human life.

While many https://whatistranshumanism.org/#what-is-a-transhuman” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://whatistranshumanism.org/#what-is-a-transhuman”> transhumanist ideals remain purely theoretical in scope, what is clear is that females are the class of humans who are being theorised out of social and political discourse. Indeed, much of the social philosophy surrounding transhumanist projects sets out to eliminate gender in the human species through the application of advanced biotechnology and assisted reproductive technologies, ultimately inspired by Shulamith Firestone’s https://teoriaevolutiva.files.wordpress.com/2013/10/fireston…lution.pdf” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://teoriaevolutiva.files.wordpress.com/2013/10/fireston…lution.pdf”> The Dialectic of Sex and much of Donna Haraway’s writing on https://warwick.ac.uk/fac/arts/english/currentstudents/under…sm_in_the_…pdf” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://warwick.ac.uk/fac/arts/english/currentstudents/under…sm_in_the_…pdf”> cyborgs. From parthenogenesis to the creation of artificial wombs, this movement seeks to remove the specificity of not gender, but sex, through the elision of medical terminology and procedures which portend to advance a technological human-cyborg built on the ideals of a post-sex model.

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