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As of this month, the US satellite Vanguard I has spent 60 years in orbit and it remains the oldest man-made object in space. Vanguard I was the fourth satellite launched into orbit — following the USSR’s Sputnik I and II and the US’ Explorer I. But none of the first three remain in orbit today and though Vanguard I can’t send signals back to Earth anymore, it’s still providing valuable data for researchers.

The first two attempts to launch the first Vanguard satellite failed, but on March 17th, 1958, Vanguard I was successfully placed into orbit. It was manufactured by the US Naval Research Laboratory (NRL), which published a lookback this week honoring the satellite’s 60 years of service, and was part of a project that aimed to study Earth’s geophysical phenomena from space. The Vanguard Project was established as part of the US contribution to the International Geophysical Year — a multi-national effort to study geophysical phenomena during a period of time when the sun’s sunspot activity would be at a peak.

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What this means

“If we look at our best numerical simulations of a magnetic field reversal, this is the type of pattern we see right before a reversal,” says Dr. Tarduno. “We don’t know if the current [anomaly] will lead to a full reversal.” If the anomaly continues to grow, the patch in the outer core under Africa could be the trigger to a full pole reversal.

If we look at our best numerical simulations of a magnetic field reversal, this is the type of pattern we see right before a reversal.

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Hey, remember that dog-like robot, SpotMini, that Boston Dynamics showed off last week, the one that opened a door for its robot friend? Well, the company just dropped a new video starring the canine contraption. In this week’s episode, a human with a hockey stick does everything in his power to stop the robot from opening the door, including tugging on the machine, which struggles in an … unsettling manner. But the ambush doesn’t work. The dogbot wins and gets through the door anyway.

The most subtle detail here is also the most impressive: The robot is doing almost all of this autonomously, at least according to the video’s description. Boston Dynamics is a notoriously tight-lipped company, so just the few sentences it provided with this clip is a relative gold mine. That information describes how a human handler drove the bot up to the door, then commanded it to proceed. The rest you can see for yourself. As SpotMini grips the handle and the human tries to shut the door, it braces itself and tugs harder—all on its own. As the human grabs a tether on its back and pulls it back violently, the robot stammers and wobbles and breaks free—still, of its own algorithmic volition.

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A group of engineers have proposed a novel approach to computing: computers made of billionth-of-a-meter-sized mechanical elements. Their idea combines the modern field of nanoscience with the mechanical engineering principles used to design the earliest computers.

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Scientists at the UNC School of Medicine and NC State have created an injectable gel-like scaffold that can hold combination #chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models so far suggest this approach could one day ramp up therapeutic benefits for patients bearing tumors or after removal of the primary tumors.

The research, published in Science Translational Medicine, focused on two specific types of melanoma and breast #cancer, but this approach could work in other tissue types. Also, the research showed that this localized delivery of combination therapy significantly inhibited the recurrence of cancer after the primary was surgically removed.

“We’ve created a simple method to use #chemotherapy while leveraging the biology of the #tumor and our natural defense against foreign invaders to beat back with limited side effects,” said senior author Zhen Gu, PhD, associate professor in the joint UNC/NCSU Biomedical Engineering Department. “We have a lot more work to do before human clinical trials, but we think this approach holds great promise.”

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It’s not uncommon for the press to get hyped up before the long process of refinement and FDA approval. Let’s hope that this one moves along quickly — while demonstrating safety and efficacy.

https://www.troab.com/worlds-first-bionic-kidney-set-replace…-two-years

Parte 3 of the SENS Research Foundation interview by LEAF is out!


Welcome to part three and the final part of our SENS Undoing Aging 2018 interview; we have a few more scientific questions today for Aubrey and his team as well as questions about future developments and taking new therapies to market.

Dr. de Grey, has your position on the relevance of telomere attrition changed since you first devised SENS, especially in the light of the recent results with fibrosis and your involvement with AgeX?

Aubrey: No. Let’s start with the big picture. Neither I nor anyone sensible has ever suggested that telomere attrition has no functional effects in aging: telomere attrition causes cells to become senescent and runs down the proliferative capacity of stem cells, amongst other things. Nor have I suggested that there wouldn’t be some short-term health benefits to activating telomerase or telomerase gene therapy in aging animals or animal models of age-related disease (or even their human equivalents). Indeed, there was plenty of animal data to support this long before the recent results with a mouse model of idiopathic pulmonary fibrosis (IPF)[1].

This piece originally appeared at the Institute for Emerging and Evolutionary Technologies website. It is dedicated to Leon Festinger.

Transhumanism is more often regarded as a faith by its detractors than its supporters. For my own part, I have long argued that the signature themes of transhumanism – especially the preoccupation with intellectual immortality and physical resurrection – bear the marks of Abrahamic theology. Indeed, without that theological backdrop, transhumanism’s zeal for mind uploading and cryonics looks simply bizarre. However, in this context, transhumanists can reasonably argue that they are scientifically delivering on those original theological promissory notes. Nevertheless, there remains the potentially pejorative sense of ‘faith’ lurking in what might be called transhumanism’s sense of eschatology – that is, its account of when, how and to whom those promissory notes will be delivered.

History shows that any humanly conceived idea is eventually realized in some form. Most of these ideas are realized fairly shortly after conception and in more or less the manner intended by their conceiver. However, many of the most important ideas – the ones that profoundly alter humanity’s self-understanding — are only realized much later and typically in a context quite alien to those who originally conceived them. Norbert Wiener famously observed that the possibility of an artificial intelligence was first raised in Talmudic discussions of the Biblical Golem. One of the goals of medieval alchemy was the creation of life from non-living materials. As for space travel and the search for extraterrestrial intelligence, they became staples of speculative thought starting with the European Renaissance’s unprecedented confidence in the power of human ingenuity. But in all these cases, the ideas have taken 500‑2000 years to be realized – and many have yet to fully satisfy the ambitions of their conceivers.

The disconnect between the conditions of intellectual conception and realization is quite familiar to writers of history and fiction. Hegel called it the ‘cunning of reason’ and it informs many a plot twist. These authors operate at a ‘meta-level’ to those who conceive and realize the ideas in question. In that respect, they move in the direction of God’s point of view. This enables them to survey with confidence a much broader bandwidth of the space-time continuum than either the conceivers or the realizers of the ideas themselves. However, what stops these second-order observers from achieving complete Olympian detachment is that they can still feel emotion about the consequences. Thus, they – and their readers — are the ones who laugh, cry or are simply amazed at the fate of ideas as they make their way from their conceivers to their realizers. Moreover, those emotions may be quite different from the ones experienced by the people depicted in the works, who by definition operate from more limited horizons and hence are ignorant of the larger narrative context.

We live in a time when many knowledgeable people are projecting radical changes to the human condition in the historical near-term, say, in the next generation or two. These include indefinite human longevity in the bodies of our birth and the prospect of artificially enhancing our minds and bodies, including the ability to upload our minds into machines capable of extending our mental powers indefinitely. Some would go further in the manner of Elon Musk to claim that space travel and colonisation might become so ordinary as to become one channel for solving humanity’s persistent earth-bound problems.

Few doubt that the time it takes to conceive and to realize the most radical ideas has shrunk over the course of history. Much of our intuitive sense of ‘acceleration’ comes from this basic awareness. It was already present in the Italian Futurist movement at the start of the twentieth century, which appealed to the accelerated pace of change – largely in the realms of transportation and communication — more than a half-century before it was operationalised in terms of computational efficiency as Moore’s Law. Moreover, humanity has become increasingly open to multiple realizations of a given idea, such that only professional historians nowadays worry about the loss of the conceiver’s original context as his or her idea comes to be realized in various ways. Indeed, the original Italian Futurists made a point of wanting to destroy all traces of the past as a precondition to freedom and progress, which they equated with the frictionless realization of the products of the human mind. Although transhumanists rarely say anything quite so nihilistic, their privileging of the ‘virtual’ over the ‘natural’ sends largely the same message.

However, transhumanists also seem to believe that the sense of space-time compression implied by an ‘accelerationist’ world-view especially favours the current generation of transhumanists. They typically locate what theologians would call the eschaton, which some transhumanists think of as the ‘singularity’, as occurring within their normal biological lifetime – certainly in less than fifty years and quite possibly within a generation. Not surprisingly, then, transhumanists tend to be middle-aged white males with a reasonable amount of disposable income. These people also tend not to have children, even if they are married. In other words, they are already prepared to enter a world in which, say, price is not a barrier to acquiring enhanced powers or extended longevity, and intergenerational succession is not something one needs to worry about, either at the personal or the public policy level.

But what happens if the eschaton does not occur within such a convenient time-frame? To be sure, I am generally optimistic that science and technology’s direction of travel points to where transhumanists want to go. Nevertheless, for various reasons, the relevant developments may not happen as soon as the likes of Ray Kurzweil or Aubrey de Grey have predicted – or hoped. In other words, the people who might end up benefitting from the transhumanist paradise that awaits Homo sapiens are the descendants of people who lived non-transhumanist lives in our times. Of course, some transhumanists believe that cryonics gets around this problem, but its prospects remain largely as speculative now as they were fifty years ago – at least with regard to human resurrection.

So, do you still believe in transhumanism even if it is unlikely that you will personally benefit from it?