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A group of researchers from Yale University and Agilent Technologies have developed a #syntheticbiology technique that turns bacterium E. Coli into a phosphorylated protein factory capable of churning out every known instance of this modification in human proteins.

Proteins, the end product of genes, carry out life functions. Most human proteins are modified by a process called serine phosphorylation — a chemical switch that can alter their structure and function. Malfunctions in this process have been implicated in diseases such as cancer and Alzheimer’s yet are difficult to detect and study. A group of researchers from Yale University and Agilent Technologies have developed a synthetic biology technique that turns bacterium E. Coli into a phosphorylated protein factory capable of churning out every known instance of this modification in human proteins.

“We synthesized over 110,000 phosphoproteins from scratch and we can now study how they all function together,” said Jesse Rinehart, associate professor of cellular and molecular physiology at the Systems Biology Institute and senior author of the research. “This is the future of scientific research — we can build everything we study.”

Previously, researchers were only able to create a single phosphoprotein at a time. The new platform will help scientists create designer proteins by studying the impact of phosphorylation on all potential protein interactions, the authors say. “Biologists want to know which proteins interact with each other because diseases can arise when these interactions go wrong,” said Karl Barber, a Yale graduate student who is the first author on the study and a recently named Schmidt Science Fellow.

Continue reading “New platform will help create designer human proteins in the lab” | >

An international team of astronomers have made the most precise test of gravity outside our own solar system.

By combining data taken with NASA’s Hubble Space Telescope and the European Southern Observatory’s Very Large Telescope, their results show that gravity in this galaxy behaves as predicted by Albert Einstein’s general theory of relativity, confirming the theory’s validity on galactic scales.

In 1915 Albert Einstein proposed his general theory of relativity (GR) to explain how gravity works. Since then GR has passed a series of high precision tests within the solar system, but there have been no precise tests of GR on large astronomical scales.

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The Himalayan Range includes some of the youngest and most spectacular mountains on Earth, but the rugged landscape that lends it the striking beauty for which it is known can also keep scientists from fully understanding how these mountains formed. “We know more about the rocks on parts of Mars than we do about some of the areas in the Himalaya,” said Dr. Alka Tripathy-Lang.

“Many researchers have done extraordinary geologic mapping in this rugged region, but the fact is that some places are just completely inaccessible because of topography, elevation, or geopolitical issues. The rocks in those areas are an important piece of the tectonic puzzle and are important for understanding the way the region evolved,” said Dr. Wendy Bohon. “The tools we used, originally developed for mapping rocks on Mars, were a way to safely access information about the rocks in the Himalayas.”

Bohon and colleagues worked with researchers at the Mars Space Flight Facility at Arizona State University to use data from the Earth orbiting satellite Terra in the same way planetary geologists have been using data from the Mars orbiting satellite Odyssey.

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Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice.

In a study published by Cell Reports, the scientists use a new bioengineering process they developed called a self-condensation cell culture. The technology helps nudge medical science closer to one day growing human organ tissues from a person’s own cells for regenerative therapy, say study investigators at Cincinnati Children’s Hospital Medical Center in the U.S. and Yokohama City University (YCU) in Japan.

“This method may serve as a principal curative strategy for treating type 1 diabetes, of which there are 79,000 new diagnoses per year,” said Takanori Takebe, MD, a physician-scientist at the Cincinnati Children’s Center for Stem Cell and Organoid Medicine. “This is a life-threatening disease that never goes away, so developing effective and possibly permanent therapeutic approaches would help millions of children and adults around the world.”

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Aside from dark matter and the dark energy that comprised the universe, there remained to be 5 percent of what was called the “ordinary matter.” About two-thirds of this ordinary matter was left unaccounted for until now. ( Harvard-Smithsonian Center for Astrophysics )

After a 20-year-long experiment, a team of international scientists detects the last of the missing intergalactic material predicted to be created by the Big Bang.

Specifically, the team was finally able to detect the missing parts of the “ordinary matter” that makes up everything in the universe, from the stars to the cores of black holes. This ordinary matter is different from the “dark matter” that comprised the bulk of the universe’s mass. The dark matter remained to be undetected until now.

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It seems that Microsoft isn’t done experimenting with blockchain technology.

Microsoft and Ernst & Young (EY) announced the launch of a blockchain solution for content rights and royalties management on Wednesday.

The blockchain solution is first implemented for Microsoft’s game publisher partners. Indeed, gaming giant Ubisoft is already experimenting with the technology.

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