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Quantum Biology Meets AI to Give CRISPR a Microbial Makeover

At Oak Ridge National Laboratory (ORNL), quantum biology, artificial intelligence, and bioengineering have collided to redefine the landscape of CRISPR Cas9 genome editing tools. This multidisciplinary approach, detailed in the journal Nucleic Acids Research, promises to elevate the precision and efficiency of genetic modifications in organisms, particularly microbes, paving the way for enhanced production of renewable fuels and chemicals.

CRISPR is adept at modifying genetic code to enhance an organism’s performance or correct mutations. CRISPR Cas9 requires a guide RNA (gRNA) to direct the enzyme to its target site to perform these modifications. However, existing computational models for predicting effective guide RNAs in CRISPR tools have shown limited efficiency when applied to microbes. ORNL’s Synthetic Biology group, led by Carrie Eckert, observed these disparities and set out to bridge the gap.

“A lot of the CRISPR tools have been developed for mammalian cells, fruit flies, or other model species. Few have been geared towards microbes where the chromosomal structures and sizes are very different,” explained Eckert.

Nvidia introduces the H200, an AI-crunching monster GPU that may speed up ChatGPT

On Monday, Nvidia announced the HGX H200 Tensor Core GPU, which utilizes the Hopper architecture to accelerate AI applications. It’s a follow-up of the H100 GPU, released last year and previously Nvidia’s most powerful AI GPU chip. If widely deployed, it could lead to far more powerful AI models—and faster response times for existing ones like ChatGPT—in the near future.

According to experts, lack of computing power (often called “compute”) has been a major bottleneck of AI progress this past year, hindering deployments of existing AI models and slowing the development of new ones. Shortages of powerful GPUs that accelerate AI models are largely to blame. One way to alleviate the compute bottleneck is to make more chips, but you can also make AI chips more powerful. That second approach may make the H200 an attractive product for cloud providers.

Popular AI platform introduces rewards system to encourage deepfakes of real people

The “bounties” feature has mostly been used to recreate women (big surprise.)

Civitai, an online marketplace for sharing AI models, just introduced a new feature called “bounties” to encourage its community to develop passable deepfakes of real people, as originally reported by 404 Media.


Popular AI platform Civitai just launched a feature called ‘bounties’ that encourages the community to create passable deepfakes upon request. The best one gets some fake money.

AI is going to ‘turbocharge winners’ faster than anyone is expecting, predicts an MIT research scientist

Risk is certainly an area of concern for CFOs when it comes to implementing generative AI.

However, Andrew McAfee, a principal research scientist at MIT, has a message for CFOs regarding the technology: “Risk tolerance needs to shift,” McAfee said.


“The risks are real, but they are manageable,” Andrew McAfee told a group of CFOs.

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