Lifeboat Foundation

The last decade has brought a lot of attention to the use of microscopic robots (microrobots or nanorobots) for biomedical applications. Now, nanoengineers have developed microrobots that can swim around in the lungs and deliver medication to be used to treat bacterial pneumonia. A new study shows that the microrobots safely eliminated pneumonia-causing bacteria in the lungs of mice and resulted in 100% survival. By contrast, untreated mice all died within three days after infection.

The results are published Nature Materials in the paper, “Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia.”

The microrobots are made using click chemistry to attach antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles to natural microalgae. The hybrid microrobots could be used for the active delivery of antibiotics in the lungs in vivo.

Scientists have been able to direct a swarm of microscopic swimming robots to clear out pneumonia microbes in the lungs of mice, raising hopes that a similar treatment could be developed to treat deadly bacterial pneumonia in humans.

The microbots are made from algae cells and covered with a layer of antibiotic nanoparticles. The algae provide movement through the lungs, which is key to the treatment being targeted and effective.

In experiments, the infections in the mice treated with the algae bots all cleared up, whereas the mice that weren’t treated all died within three days.

There needs to be a radical change to biological wetware in order to handle viruses. What is needed is either nanoparticles or an immunity to all diseases. Crispr is the main path for the biological singularity but it needs to be perfected first as the human body is still a black box due to restrictions. I do believe that mass spectrometry will essentially be key to see the inner world of human biology. Then crispr can make new parts essentially to evolve past our current limits. But either way the biological singularity is needed for survival of human beings for better health.

The coronavirus revealed flaws in the nation’s pandemic plans. The spread of monkeypox shows that the problems remain deeply entrenched.

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Jennifer Garrison, Buck Institute.
Reframing Health and Aging through the Lens of Reproduct.

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This year’s Breakthrough Prize in Life Sciences has a strong physical sciences element. The prize was divided between six individuals. Demis Hassabis and John Jumper of the London-based AI company DeepMind were awarded a third of the prize for developing AlphaFold, a machine-learning algorithm that can accurately predict the 3D structure of proteins from just the amino-acid sequence of their polypeptide chain. Emmanuel Mignot of Stanford University School of Medicine and Masashi Yanagisawa of the University of Tsukuba, Japan, were awarded for their work on the sleeping disorder narcolepsy.

The remainder of the prize went to Clifford Brangwynne of Princeton University and Anthony Hyman of the Max Planck Institute of Molecular Cell Biology and Genetics in Germany for discovering that the molecular machinery within a cell—proteins and RNA—organizes by phase separating into liquid droplets. This phase separation process has since been shown to be involved in several basic cellular functions, including gene expression, protein synthesis and storage, and stress responses.

The award for Brangwynne and Hyman shows “the transformative role that the physics of soft matter and the physics of polymers can play in cell biology,” says Rohit Pappu, a biophysicist and bioengineer at Washington University in St. Louis. “[The discovery] could only have happened the way it did: a creative young physicist working with an imaginative cell biologist in an ecosystem where boundaries were always being pushed at the intersection of multiple disciplines.”

Researchers have developed a metasurface device that can display three types of images depending on the illumination light. The three-channel device could be used as an anticounterfeiting measure or offer a new way to securely deliver encrypted information.

“Metasurfaces are artificial materials with tiny nanostructures that can be used to manipulate light,” said research team member Qi Dai from Wuhan University in China. “In this work, we exploited both the size and orientation of the nanostructures to design a metasurface with three working modes.”

The researchers describe the new device in Optics Express. They also showed that depending on the light used, the metasurface would generate a holographic image or a structural-color nanoprinting image with or without polarization-dependent watermarks.

Daegu Gyeongbuk Institute of Science & Technology (DGIST, President Yang Kook) Professor Hongsoo Choi’s team of the Department of Robotics and Mechatronics Engineering collaborated with Professor Sung-Won Kim’s team at Seoul St. Mary’s Hospital, Catholic University of Korea, and Professor Bradley J. Nelson’s team at ETH Zurich to develop a technology that produces more than 100 microrobots per minute that can be disintegrated in the body.

Microrobots aiming at minimal invasive targeted precision therapy can be manufactured in various ways. Among them, ultra-fine 3D printing technology called two-photon polymerization method, a method that triggers polymerization by intersecting two lasers in synthetic resin, is the most used. This technology can produce a structure with nanometer-level precision. However, a disadvantage exists in that producing one microrobot is time consuming because voxels, the pixels realized by 3D printing, must be cured successively. In addition, the magnetic nanoparticles contained in the robot can block the light path during the two-photon polymerization process. This process result may not be uniform when using magnetic nanoparticles with high concentration.

To overcome the limitations of the existing microrobot manufacturing method, DGIST Professor Hongsoo Choi’s research team developed a method to create microrobots at a high speed of 100 per minute by flowing a mixture of magnetic nanoparticles and gelatin methacrylate, which is biodegradable and can be cured by light, into the microfluidic chip. This is more than 10,000 times faster than using the existing two-photon polymerization method to manufacture microrobots.

Epitaxy on nanopatterned graphene enables the realization of a broad spectrum of freestanding single-crystalline membranes with substantially reduced defects.

Skoltech scientists modeled the behavior of nanobubbles appearing in van der Waals heterostructures and the behavior of substances trapped inside the bubbles. In the future, the new model will help obtain equations of state for substances in nano-volumes, opening up new opportunities for the extraction of hydrocarbons from rock with large amounts of micro-and nanopores. The results of the study were published in the Journal of Chemical Physics.

The van der Waals nanostructures hold much promise for the study of tiniest samples with volumes from 1 cubic micron down to several cubic nanometers. These atomically thin layers of two-dimensional materials, such as graphene, hexagonal boron nitride (hBN) and dichalcogenides of transition metals, are held together by weak van der Waals interaction only. Inserting a sample between the layers separates the upper and bottom layers, making the upper layer lift to form a nanobubble. The resulting structure will then become available for transmission electron and atomic force microscopy, providing an insight into the structure of the substance inside the bubble.

The properties exhibited by substances inside the van der Waals nanobubbles are quite unusual. For example, water trapped inside a nanobubble displays a tenfold decrease in its dielectric constant and etches the diamond surface, something it would never do under normal conditions. Argon which typically exists in liquid form when in large quantities can become solid at the same pressure if trapped inside very small nanobubbles with a radius of less than 50 nanometers.