Lifeboat Foundation

Solar cells that are stretchable, flexible and wearable won the day and the best poster award from a pool of 215 at Research Expo 2016 April 14 at the University of California San Diego. The winning nanoengineering researchers aim to manufacture small, flexible devices that can power watches, LEDs and wearable sensors. The ultimate goal is to design and build much bigger flexible solar cells that could be used as power sources and shelter in natural disasters and other emergencies.

Research Expo is an annual showcase of top graduate research projects for the Jacobs School of Engineering at UC San Diego. During the poster session, graduate students are judged on the quality of their work and how well they articulate the significance of their research to society. Judges from industry, who often are alumni, pick the winners for each department. A group of faculty judges picks the overall winner from the six department winners.

Continue reading “Stretchable, Flexible, Wearable Solar Cells Take Top Prize at Research Expo 2016” »

Traumatic brain injuries might have faded from the headlines since the NFL reached a $765 million settlement for concussion-related brain injuries, but professional football players aren’t the only ones impacted by these injuries. Each year, between 2 million and 3 million Americans suffer from traumatic brain injuries—from elderly people who fall and hit their head, to adolescents playing sports or falling out of trees, to people in motor vehicle accidents.

There are currently no treatments to stop the long-term effects of a traumatic brain injury (TBI), and accurate diagnosis requires a visit to a medical center for a CT scan or MRI, both of which involve large, expensive equipment.

UC San Diego bioengineering Professor Ester Kwon, who leads the Nanoscale Bioengineering research lab at the Jacobs School of Engineering, aims to change that. Kwon’s team is developing nanomaterials—materials with dimensions on the nanometer scale—that could be used to diagnose traumatic brain injury on the spot, be it a sports field, the scene of a car accident, or a clinical setting. They’re also engineering nanoparticles that could target the portion of the patient’s brain that was injured, delivering specific therapeutics to treat the injury and improve the patient’s long-term quality of life.

As nanotechology burrows into an increasing number of medical technologies, new developments in nanoparticles point to the ways that treatments can today be nanotechnologically targeted. In one case, would-be end effectors on microrobots are aimed at clearing up cases of bacterial pneumonia. In another, a smart-targeting system may decrease clotting risks in dangerous cases of thrombosis.

Scientists from the University of California, San Diego, demonstrated antibiotic-filled nanoparticles that hitch a ride on microbots made of algae to deliver targeted therapeutics. Their paper was recently published in Nature Materials. As a proof of concept, the researchers administered antibiotic-laden microbots to mice infected with a potentially fatal variety of pneumonia (a strain that is common in human patients who are receiving mechanical ventilation in intensive-care settings). All infections in the treated mice cleared up within a week, while untreated mice died within three days.

The algae–nanoparticle hybrid microbots were effectively distributed to infected tissue through lung fluid and showed negligible toxicity. “Our goal is to do targeted drug delivery into more challenging parts of the body, like the lungs,” said bioengineering professor Liangfang Zhang in a press statement. “And we want to do it in a way that is safe, easy, biocompatible, and long lasting.”

To produce the next generation of high-frequency antennae for 5G, 6G and other wireless devices, a team at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has invented the machine and manufacturing technique to manipulate microscopic objects using 3D printing and braid them into filaments a mere micrometre in diameter.

How small is this? One human hair varies in diameter between 20 and 200 micrometres from tip to root. Spider web silk can vary from 3 to 8 micrometres in diameter. So that’s teeny tiny. And for us to pack in the many antennae that go into mobile phone technology today, the smaller the better.

Continue reading “Water-Braiding Technology Invented For Next Generation Wireless Devices” »

A team of researchers from Korea University, Ajou University and Hanyang University, all in the Republic of Korea, has created a tiny aquabot propelled by fins made of a porous hydrogel imbued with nanoparticles. In their paper published in the journal Science Robotics, the group describes how the hydrogel works to power a tiny boat and reveals how much voltage was required.

Scientists and engineers have been working for several years to build tiny, soft robots for use in medical applications and have found that hydrogels are quite suitable for the task. Unfortunately, such materials also have undesirable characteristics, most notably, poor electro-connectivity. In this new effort, the researchers took a new approach to making hydrogels more amenable for use with electricity as a power source —adding conductive nanoparticles.

Continue reading “Incorporating nanoparticles into a porous hydrogel to propel an aquabot with minimal voltage” »

A Ludwig Cancer Research study has developed a novel nanotechnology that triggers potent therapeutic anti-tumor immune responses and demonstrated its efficacy in mouse models of multiple cancers. Led by Co-director Ralph Weichselbaum, investigator Wenbin Lin and postdoctoral researcher Kaiting Yang at the Ludwig Center at Chicago, the study describes the synthesis, mechanism of action and preclinical assessment of the nanoparticle, which is loaded with a drug that activates a protein central to the efficient induction of anti-cancer immunity. The study, which overcomes significant technical barriers to targeting that protein-;stimulator of interferon genes, or STING-;for cancer therapy, appears in the current issue of Nature Nanotechnology.

“The nanoparticles developed by the Lin lab release a drug that targets macrophages and can activate potent antitumor immune responses that extend the survival of mice bearing a variety of tumors,” said Chicago Center Co-director Weichselbaum. “When used in combination with radiotherapy and immunotherapy, they even help control ‘cold tumors’ that are otherwise almost completely impervious to immune attack.”

STING is part of cellular sensing system for DNA fragments, which are generated by infection or cancer treatments that damage DNA, like radiotherapy and some chemotherapies. Its activation promotes inflammation and drives immune cells like macrophages and dendritic cells to process and present cancer antigens to T cells, helping to stimulate and direct the immune assault on tumors. Though STING is a prized target for drug development, the drug-like molecules that can activate the molecular sensor-;known as cyclic dinucleotides (CDNs)-;have been plagued by issues of poor bioavailability, low stability and high toxicity in the absence of any means to target them specifically to tumors.

A team of researchers at Shanghai Jiao Tong University, working with a pair of colleagues from Harvard University, has developed a new way to synthesize single quantum nanomagnets that are based on metal-free, multi-porphyrin systems. In their paper published in the journal Nature Chemistry, the group describes their method and possible uses for it.

Molecular magnets are materials that are capable of exhibiting ferromagnetism. They are different from other magnets because their building blocks are composed of organic molecules or a combination of coordination compounds. Chemists have been studying their properties with the goal of using them to develop medical therapies such advanced magnetic resonance imaging, new kinds of chemotherapy and possibly magnetic-field-induced local hyperthermia therapy. In this new effort, the researchers have developed a way to create molecular nanomagnets with quantum properties.

The technique involved first synthesizing a monoporphyrin using what they describe as conventional “solution chemistry”—the monoporhyrins were created by using an atomic-force microscope to pull hydrogen atoms off of polyporphyrins. The researchers then applied the result to a base of gold, which they placed in an oven and heated to 80 °C. This forced the rings in the material to become chained. They then turned the oven up to 290°C and then let the material cook for another 10 minutes. This resulted in the formation of additional carbon cycles and the creation of quantum nanomagnets.

The method requires only visible light and no external heating.

Hydrogen sulfide, infamous for its aroma of rotten eggs, is known to be highly poisonous and corrosive — especially in wastewater applications. Petrochemical plants and other industries make thousands of tons of this gas every year as a byproduct of various processes that separate sulfur from petroleum, natural gas, coal, and other products.

Now, Rice University engineers and scientists have devised a new way for such petrochemical industries to turn the noxious gas into “high-demand” hydrogen gas.

Continue reading “Engineers developed a breakthrough method to generate hydrogen gas in one-step process” »

Nanotube-modified bacteria could produce electricity as living photovoltaic devices, say researchers.