Summary: A newly constructed brain map shows every single neuron and how they are wired together in the brains of fruit fly larvae.
Source: UK Research and Innovation.
Researchers have built the first ever map showing every single neuron and how they’re wired together in the brain of the fruit fly larva.
Scientists working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and—in doing so—unearthed a potential new therapeutic target.
The scientists have found that an enzyme called fumarate hydratase is repressed in macrophages, a frontline inflammatory cell type implicated in a range of diseases including lupus, arthritis, sepsis and COVID-19.
Professor Luke O’Neill, Professor of Biochemistry at Trinity, is the lead author of the research article that has just been published in the journal, Nature. He said, “No one has made a link from fumarate hydratase to inflammatory macrophages before and we feel that this process might be targetable to treat debilitating diseases like lupus, which is a nasty autoimmune disease that damages several parts of the body including the skin, kidneys and joints.”
A recent scientific breakthrough could see electricity being generated using nothing but the atmosphere, with perhaps a little added hydrogen.
The process involves an enzyme made by bacteria to help them grow and survive in environments including volcanic craters and Antarctica. The enzyme, called Huc, has been found to produce a small electrical current by consuming hydrogen in the air as a source of energy, researchers said in a paper published Wednesday in scientific journal Nature.
Transcatheter mitral valve repair for heart failure patients with mitral regurgitation can reduce the long-term rate of hospitalizations by almost 50 percent, and death by nearly 30 percent, compared with heart failure patients who don’t undergo the minimally invasive procedure.
These are the breakthrough findings from a new study led by a researcher from the Icahn School of Medicine at Mount Sinai. This multi-center trial is the largest trial to examine the safety and effectiveness of transcatheter mitral-valve repair in a heart failure population using Abbott’s MitraClip system. It shows this treatment option significantly improves outcomes for patients with heart failure that do not respond to conventional treatments.
The five-year results from the “Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Device” study, or COAPT, were announced Sunday, March 5, in a Late Breaking Clinical Trial presentation at the American College of Cardiology Scientific Sessions Together with World Congress of Cardiology (ACC.23/WCC) in New Orleans, and published in The New England Journal of Medicine.
A new test finally ignited a nuclear fusion reaction that unleashed more energy than it took in. This raises hopes that someday the reaction that powers the sun could also cleanly power activities here on Earth.
The experiment took place at the National Ignition Facility in Livermore, Calif. The U.S. Department of Energy announced its achievement on December 13.
“This is a monumental breakthrough,” says Gilbert Collins. This physicist works at the University of Rochester in New York and did not take part in the new research. “Since I started in this field, fusion was always 50 years away,” Collins says. “With this achievement, the landscape has changed.”
Researchers hope KRAS test can serve renewed function as soon as possible Scientists have found an existing gene test frequently used on the NHS can also shed light on whether a bowel cancer patient will respond positively or negatively to chemotherapy. Researchers from The Institute of Cancer Research, Imperial College London and the Netherlands Cancer Institute have found the KRAS test can have use beyond its current function of predicting how patients will react to cancer drug cetuximab.
A ranking of the most innovative companies in AI, including OpenAI, DeepMind, Nvidia, Builder.ai, Voxel, and others.
A joint effort in chemistry has resulted in an innovative method for utilizing carbon dioxide in a positive – even beneficial – manner: through electrosynthesis, it is integrated into a series of organic molecules that play a crucial role in the development of pharmaceuticals.
During the process, the team made an innovative discovery. By altering the type of electrochemical reactor used, they were able to generate two distinct products, both of which are useful in medicinal chemistry.
The team’s paper was recently published in the journal Nature. The paper’s co-lead authors are postdoctoral researchers Peng Yu and Wen Zhang, and Guo-Quan Sun of Sichuan University in China.
A team of scientists, including physicist Eugene Demler from ETH Zurich, for the first time, closely observed how magnetic correlations play a role in mediating hole pairing.
Superconductivity only occurs in pairs. Therefore, in order for conductance without electrical resistance to take place in specific materials, the charge carriers must pair up. In traditional superconductors, the current is made up of electrons and pairing is facilitated by the collective movements of the crystal lattice, referred to as phonons. This mechanism is well understood. However, in recent decades, a growing number of materials have been found that don’t fit within this conventional theoretical framework.
The leading theories for unconventional superconductors suggest that magnetic fluctuations, not phonons, lead to pairing in these systems, — and surprisingly, magnetic interactions arise from the repulsive Coulomb interaction between electrons. However, verifying these models in experiments is extremely difficult.
