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Category: health – Page 447

High-performance detectors that are compatible with mainstream semiconductor device fabrication deliver high speed, ultra-sensitivity, and good timing resolution.

Recent advances in biomedical imaging include the enhancement of image contrast, 3D sectioning capability, and compatibility with specialized imaging modes such as fluorescence lifetime imaging (FLIM).1–3 Compared with other imaging methods, FLIM offers the highest image contrast because it measures the lifetime of the fluorescence, rather than just its intensity or wavelength characteristics. The contrasting fluorescence lifetime attributes can then enable the observer to discriminate between regions, such as identifying healthy and diseased tissue for cancer detection. In conventional FLIM, a discrete single-photon detector, typically based on photomultiplier tube (PMT) technology, enables the acquisition of a single focal spot.4 This focal spot is then raster-scanned across the field of view to form an image. This approach, however, requires sequential scanning—pixel by pixel—and thus results in a slow image acquisition rate.

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If you are interested in the work of SENS and how Dr Haroldo Silva and his team are looking for ways to treat cancer why not come along and join them?

There is going to be a SENS AMA on Reddit with Aubrey de Grey and OncoSENS researcher Haroldo Silva. Ask them anything about SENS and the long term goal of developing universal cancer therapies.

FUTUROLOGY JULY 19TH 1 pm EST/10 am PST/6 pm BST.

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Is it time for rehab for junk food junkies?

Apparently, all the burgers and smoothies you’re consuming cause your brain to forget to stop eating even when you’re full.

Can you relate to midnight cravings and the feeling of perpetual hunger? Do you resort to grabbing fast food on the fly or eating out of a tub of ice cream while you’re bored around the house?

New research reveals obesity may be a brain disease that worsens in people with a diet high in sugar and fat. People who are diet conscious and eat healthy are less likely to indulge in sweet cravings and unhealthy snacks, since their brain recalls a sense of fulfillment derived from watching what they eat. Consuming sugars and fats hinders the functioning of the hippocampus area of one’s brain, blocking from their mind the memories of when their stomach felt full.

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Elite athletes need never miss an opportunity to train again, even when they’re 40,000 feet above the ground.

A new luxury private plane for sports teams aims to keep athletes in top shape while travelling to and from events, thanks to on-board training facilities including exercise bikes and massage tables.

Russian luxury jet firm Sukhoi unveiled its concept SportJet at the Farnborough International Airshow in Hampshire this week.

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Interesting.

WHAT: Scientists at the National Institutes of Health are reporting new, unexpected details about the fundamental structure of collagen, the most abundant protein in the human body. In lab experiments, they demonstrated that collagen, once viewed as inert, forms structures that regulate how certain enzymes break down and remodel body tissue. The finding of this regulatory system provides a molecular view of the potential role of physical forces at work in heart disease, cancer, arthritis, and other disease-related processes, they say. The study appears in the current online issue of the Proceedings of the National Academy of Sciences.

Scientists have known for years that collagen remodeling plays an important role in a wide variety of biological processes ranging from wound healing to cancer growth. In particular, researchers know that collagen is broken down by a certain class of enzymes called matrix metalloproteinases (MMPs), but exactly how they did this remained somewhat of a mystery, until now.

In the NIH study, the scientists isolated individual, nano-sized collagen fibrils from rat-tail tendons. They then exposed the collagen fibrils to fluorescently-labeled human MMP enzymes. Using video microscopy, the scientists tracked thousands of enzymes moving along a fibril. Unexpectedly, the scientists observed that the enzymes preferred to attach at certain sites along the fibril, and over time these attachment sites slowly moved, or disappeared and reappeared in other positions. These observations revealed collagen fibrils have defects that spontaneously form and heal. In the presence of tension, such as when tendons stretch, defects are likely eliminated, preventing enzymes from breaking down collagen that is loaded by physical force, the researchers suggest. In short, they identified a possible strain-sensitive mechanism for regulating tissue remodeling.

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Ray Kurzweil is a celebrity technologist, well known both for his work as an inventor and for his relatively accurate predictions of technological change. Among his predictions is that of an imminent biotech revolution, which may enable people to restore and maintain healthy life for much longer periods of time than those humans have enjoyed historically. In the meantime, Ray says he takes 250 dietary supplements each day, in addition to receiving half a dozen intravenous therapies each week.

“Although my program may seem extreme, it is actually conservative – and optimal (based on my current knowledge). [My doctor] and I have extensively researched each of the several hundred therapies that I use for safety and efficacy. I stay away from ideas that are unproven or appear to be risky (the use of human-growth hormone, for example).” – Ray Kurzweil in The Singularity Is Near (pages 211–212)

Some of Ray’s dietary supplements are nootropics, intended to maintain and improve brain health. He lists them in his book, Transcend (pages 15 and 22). I’ve compared the nootropics he recommends to reviews on Examine.com, an independent and unbiased encyclopedia on supplementation and nutrition that is not affiliated in any way with any supplement company. Below is a table that summarizes what I found, followed by some observations.

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Nice chime on QC.

Manoj Saxena is the executive chairman of CognitiveScale and a founding managing director of The Entrepreneurs’ Fund IV (TEF), a $100m seed fund focused exclusively on the cognitive computing space.

Saxena is also the chairman of Federal Reserve Bank of Dallas, San Antonio branch and Chairman, SparkCognition an Austin based cognitive security and safety analytics company.

Prior to joining TEF, Saxena was general manager, IBM Watson, where his team built the world’s first cognitive systems in healthcare, financial services, and retail. Earlier he founded, built and sold two Austin based software startups.

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Are pomegranates really the superfood we’ve been led to believe will counteract the aging process? Up to now, scientific proof has been fairly weak. And some controversial marketing tactics have led to skepticism as well. A team of scientists from EPFL and the company Amazentis wanted to explore the issue by taking a closer look at the secrets of this plump pink fruit. They discovered that a molecule in pomegranates, transformed by microbes in the gut, enables muscle cells to protect themselves against one of the major causes of aging. In nematodes and rodents, the effect is nothing short of amazing. Human clinical trials are currently underway, but these initial findings have already been published in the journal Nature Medicine.

As we age, our cells increasingly struggle to recycle their powerhouses. Called mitochondria, these inner compartments are no longer able to carry out their vital function, thus accumulate in the cell. This degradation affects the health of many tissues, including muscles, which gradually weaken over the years. A buildup of dysfunctional mitochondria is also suspected of playing a role in other diseases of aging, such as Parkinson’s disease.

One molecule plays David against the Goliath of aging

The scientists identified a molecule that, all by itself, managed to re-establish the cell’s ability to recycle the components of the : urolithin A. “It’s the only known molecule that can relaunch the mitochondrial clean-up process, otherwise known as mitophagy,” says Patrick Aebischer, co-author on the study. “It’s a completely natural substance, and its effect is powerful and measurable.”

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