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The compositional and functional diversity of the gut fungal microbiome

In a recent study published in The Lancet Microbe, researchers assessed the role of gut bacterial microbiome assembly and the gut mycobiome in relation to health, pathology, and clinical applications.

Studies have built a framework for investigating how gut fungi are connected to—or perhaps cause—different diseases and how to alter gut fungi to treat diseases by revealing the landscape of gut mycobiome composition in humans. Importantly, available mycobiome discoveries are not extensively applied to clinical practice, and gut fungi are still widely ignored in the context of treatments based on the microbiota.

According to studies conducted on mice, altering the intestinal fungi through oral administration of antifungal medications worsened allergic rhinitis and colitis, indicating that an imbalance in the gut mycobiome may play a role in the pathogenesis of intestinal as well as extra-intestinal diseases. Similar comparisons between the gut mycobiomes of healthy people and patients with various intestinal and extra-intestinal disorders have been documented in many studies.

New study shows transmission of epigenetic memory across multiple generations

Without altering the genetic code in the DNA, epigenetic modifications can change how genes are expressed, affecting an organism’s health and development. The once radical idea that such changes in gene expression can be inherited now has a growing body of evidence behind it, but the mechanisms involved remain poorly understood.

A new study by researchers at UC Santa Cruz shows how a common type of epigenetic modification can be transmitted via sperm not only from parents to offspring, but to the next generation (“grandoffspring”) as well. This is called “transgenerational epigenetic inheritance,” and it may explain how a person’s health and development could be influenced by the experiences of his or her parents and grandparents.

The study, published the week of September 26 in the Proceedings of the National Academy of Sciences (PNAS), focused on a particular modification of a histone protein that changes the way DNA is packaged in the chromosomes. This widely studied epigenetic mark (called H3K27me3) is known to turn off or “repress” the affected genes and is found in all multicellular animals—from humans to the nematode worm C. elegans used in this study.

‘Love hormone’ is revealed to have heart healing properties

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.

Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another unsuspected function: It stimulates derived from the heart’s outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, that generate heart contractions. This discovery could one day be used to promote the regeneration of the human heart after a . The results are published in Frontiers in Cell and Developmental Biology.

“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” said Dr. Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study’s senior author.

Diets high in processed fiber may increase risk of liver cancer

Sometimes, it can be hard to follow dietary recommendations despite new dieting ideas and trends.

Everyone’s dietary needs are different, which means that diets often need to be diverse and tailored based on individual needs and health risks.

A recent study published in Gastroenterology looked at diets high in fermentable fiber in mice and their associated risk for developing liver cancer.

Rehabilitating spinal cord injury and stroke with graphene and gaming

Few human injuries are as catastrophic as those to the spine. An accident, disease or act of violence affecting the spine can result in poor function – even paralysis – almost anywhere in the body.

The spinal column is enormously complex, with limited capacity for regeneration and any health implications are usually long-term and chronic.

While there is no known way to repair a spinal cord injury (SCI), scientists may be on the cusp of some important breakthroughs. New approaches are being taken to reverse the nerve damage, with some researchers attempting to reshape the architecture of the spinal cord using materials engineered in the laboratory.

Closer Study of Major Autism Gene Suggests Possible Treatment Approach

In adult mice with loss of CHD8 gene function, FDA-approved drug partially restores disrupted brain cell production

CINCINNATI, Sept. 23, 2022 /PRNewswire/ — Research led by a scientist at Cincinnati Children’s who primarily studies brain tumors may open doors for improved treatment of autism.

Autism spectrum disorder (ASD) affects about one in 40 children between ages 3 and 17, according to the National Survey of Children’s Health. Those affected often experience difficulty socializing, impaired language development, repetitive behaviors, and other symptoms. Of those tested for various genes linked to the condition, nearly everyone with disruptive mutations of the gene CHD8 has autism.

7 Harmful Side Effects of Excessive Consumption of Green Tea

Research and blogs talk a lot about the health benefits of green tea. It’s rich in antioxidants and flavonoids, which have positive influences on our physical and mental well-being. Some studies show that green tea can boost metabolism, reduce inflammation and improve cognitive function.

But what’s less talked about are the side effects of green tea. They may be uncommon, but that doesn’t mean they don’t deserve discussion! This is of particular importance to those who have caffeine sensitivity or who may be taking certain medications which interact with caffeine and other bioactive components in green tea.

So before you brew yourself a cup, read on about the potential side effects of drinking green tea so you’re fully educated about what you’re consuming.

Polio declared imminent threat to public health in New York

“From day one, we’ve taken an aggressive public health approach to combat the spread of polio and ensure New Yorkers are protected,” Hochul said. “This declaration will bolster our ongoing efforts to protect New Yorkers against paralytic disease, prevent spread, and support our public health partners.”

Public health officials at the county level will have expanded ability to receive funding and resources for immunization clinics and conduct outreach for unvaccinated and under-vaccinated New York residents. Local health officials will be able to claim a reimbursement for these efforts, back dated to July 21 and running through Dec. 31.

“Working daily with local county health departments, our partners at CDC, and trusted leaders, the Department is working effectively to increase childhood and community vaccination rates in counties where the virus has been detected,” Bassett said. “Thanks to long-established school immunization requirements, the vast majority of adults, and most children, are fully vaccinated against polio. Our focus remains on ensuring the on-time administration of polio vaccination among young children and catching kids and adults up who are unimmunized and under-immunized in the affected areas. That work continues at full force.”

Researchers identify new model of Alzheimer’s as an autoimmune disease

Scientists at the Krembil Brain Institute, part of the University Health Network, have proposed a new mechanistic model (AD2) for Alzheimer’s, looking at it not as a brain disease, but as a chronic autoimmune condition that attacks the brain.

This novel research is published today, in Alzheimer’s & Dementia.

“We don’t think of Alzheimer’s as fundamentally a disease of the . We think of it as a disease of the immune system within the brain,” says Dr. Donald Weaver, co-Director of the Krembil Brain Institute and author of the paper.

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