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Illustrated is the power of combined interference with different DNA damage response processes to combat cancer: Homologous recombination, which is selectively deficient in the tumour due to the BRCA defect, and base excision repair of single strand breaks, which is blocked by the administration of PARP inhibitors.

Client:
Dr. Rini de Crom.
Dr. Marja Miedema.
www.erasmusmc.nl, 2014

www.ddresponse.eu/

Funded by the 7th Framework Programme of the European Commission in the theme Health.

Losing as little as 6–7 minutes per day to sedentary behavior or low-intensity activities has been linked to a decline in cognitive function, according to recent research.

The daily time spent in moderate and intense physical activity is linked to mid-life brain power, according to new research published in the Journal of Epidemiology & Community Health.

The results indicate that the optimal level for working memory and mental tasks, such as planning and organization, is at this intensity level. Replacing it with just 6–7 minutes of light-intensity activities or sedentary behavior per day is linked to decreased cognitive performance.

Israeli scientists have developed a substance that overcomes antibiotic resistance by “pricking bacteria to death,” researchers at Ben Gurion University told the Times of Israel on Friday, in a breakthrough that could help combat a major threat to global health.

The substance contains “nano needles” which have a lethal effect on bacteria, and will be developed into topical creams and antibacterial coatings for surfaces, the scientists said, noting that it has shown 90% effectiveness in killing antibiotic-resistant bacteria in lab conditions.

When bacteria stop being affected by antibiotics, it is known as antibiotic resistance, and these pathogens are sometimes colloquially called superbugs.

Though no one died in the accident, the catastrophe serves as a wake-up call to the potential for more deadly freight rail derailments, public health advocates warn. By one estimate, 25 million Americans live in an oil train blast zone, and had the derailment occurred just a few miles east, it would be burning in downtown Pittsburgh, with tens of thousands of residents in immediate danger.

Ineffective oversight and a largely self-monitoring industry that has cut the nation’s rail workforce to the bone in recent years as it puts record profits over safety is responsible for the wreck, said Ron Kaminkow, an Amtrak locomotive engineer and former Norfolk Southern freight engineer.

“The Palestine wreck is the tip of the iceberg and a red flag,” said Kaminkow, who is secretary for the Railroad Workers United, a non-profit labor group that coordinates with the nation’s rail unions. “If something is not done, then it’s going to get worse, and the next derailment could be cataclysmic.”

Researchers from The University of Queensland have discovered the active compound from an edible mushroom that boosts nerve growth and enhances memory.

Professor Frederic Meunier from the Queensland Brain Institute said the team had identified new active compounds from the mushroom, Hericium erinaceus. This type of edible mushroom, commonly known as the Lion’s Mane Mushroom, is native to North America, Europe, and Asia. It is commonly sought after for its unique flavor and texture, and it is also used in traditional Chinese medicine to boost the immune system and improve digestive health.

Researchers have discovered lion’s mane mushrooms improve brain cell growth and memory in pre-clinical trials.

Over the past decade, I’ve kept a close eye on the emergence of artificial intelligence in healthcare. Throughout, one truth remained constant: Despite all the hype, AI-focused startups and established tech companies alike have failed to move the needle on the nation’s overall health and medical costs.

Finally, after a decade of underperformance in AI-driven medicine, success is approaching faster than physicians and patients currently recognize.


The next version, ChatGPT4, is scheduled for release later this year, as is Google’s rival AI product. And, last week, Microsoft unveiled an AI-powered search engine and web browser in partnership with OpenAI, with other tech-industry competitors slated to join the fray.

It remains to be seen which company will ultimately win the generative-AI arms race. But regardless of who comes out on top, we’ve reached a tipping point.

In 2021, Carbon Robotics unveiled the third-generation of its Autonomous Weeder, a smart farming robot that identifies weeds and then destroys them with high-power lasers. The company now has taken the technology from that robot and built a pull-behind LaserWeeder — and it kills twice as many weeds.

The weedkiller challenge: Weeds compete with plants for space, sunlight, and soil nutrients. They can also make it easier for insect pests to harm crops, so weed control is a top concern for farmers.

Chemical herbicides can kill the pesky plants, but they can also contaminate water and affect soil health. Weeds can be pulled out by hand, but it’s unpleasant work, and labor shortages are already a huge problem in the agriculture industry.

We take them for granted until we can’t. That’s why people react so strongly to the fear of losing their memories — either by forgetting small things in the sort term (which we all do; don’t worry), or else the fear of either us or a loved one suffering from memory loss in our older age.

And, that’s why I’d like to talk today about habits and brain health, and cinnamon.

Yes, cinnamon, the tasty and sweet-smelling spice originating in Asia, and found liberally in the U.S., combined with raisins on bagels, toast, pastries, even big boxes of processed cereal with cartoon characters on the front.

We all know that exercise is good for our health. But besides lowering the risk of obesity or type II diabetes, exercise has also been shown to benefit our brain. More precisely, exercise modifies parts of the brain and improves memory, attention and improves mood. Regular exercise further lowers the risk to suffer from dementia or depression. But how does exercise benefit our brains?

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Philosophers have speculated for centuries that exercise promotes our brain functionality but only a few decades ago, scientists uncovered that this is true. Studies have shown that children who are more athletic perform better in creativity, concentration, maths verbal and IQ tests. These children also tend to have a larger hippocampus and basal ganglia both of which are important for memory and attention span. Adults who started to workout regularly also have changes in their brain and perform better in various tests. There are several mechanisms which explain this phenomenon. When we exercise, brain cells release VEGF which helps to supply the brain with oxygen. Moreover, neurotrophins are released when we workout which helps the survival of brain cells. Exercise also seems to improve neuroplasticity through the same pathways. Since exercise leads to the release of neurotransmitters such as serotonin, workouts also have been used to treat mental disorders such as depression. In various studies it was seen exercise helps to alleviate the symptoms of people who suffer from major depression.

The new disease could provide insights into how the cell’s recycling system contributes to a healthy brain. Researchers at the National Institutes of Health have discovered a new neurological condition characterized by issues with motor coordination and speech. They identified three children with the condition, two siblings and an unrelated child.