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Closing in on a universal vaccine: Nasal spray protects mice from respiratory viruses, bacteria and allergens

In the realm of medical advancements, a universal vaccine that can protect against any pathogen has long been a Holy Grail—and about as elusive as a mythological vessel. But Stanford Medicine researchers and collaborators have taken an astonishing step forward in that quest, surprising even themselves.

In a new study in mice, they have developed a universal vaccine formula that protects against a wide range of respiratory viruses, bacteria and even allergens. The vaccine is delivered intranasally—such as through a nasal spray—and provides broad protection in the lungs for several months.

In the study, published in Science, researchers show that vaccinated mice were protected against SARS-CoV-2 and other coronaviruses, Staphylococcus aureus and Acinetobacter baumannii (common hospital-acquired infections), and house dust mites (a common allergen).

Cryogenic Arks — Sleeping Through the Ages

From frozen habitats to millennia-long journeys, we explore the science behind cryogenic arks and deep-time interstellar travel.

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Check out Joe Scott’s Oldest & Newest: https://nebula.tv/videos/joescott-old… my exclusive video Chronoengineering: https://nebula.tv/videos/isaacarthur–… 🚀 Join this channel to get access to perks: / @isaacarthursfia 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Cryogenic Arks – Sleeping Through the Ages Written, Produced & Narrated by: Isaac Arthur Select imagery/video supplied by Getty Images Music by Epidemic Sound: http://nebula.tv/epidemic & Stellardrone Chapters 0:00 Intro 2:50 The Need for Cryogenic Arks 6:12 From Freezing Flesh to Preserving Life 12:33 The Physics and Engineering of the Cryogenic Ark 18:46 The Problem of Time and Identity 24:59 Oldest & Newest 25:59 How Long Can We Stay Frozen? 30:48 Crew Dynamics and Risk 35:18 Beyond Cryogenics – Slowing Time Itself.
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Water-window X-rays without a synchrotron: How graphite flakes could shrink bioimaging tools

Researchers from Nanyang Technological University, Singapore (NTU Singapore) have found a new way to produce X-rays with wavelengths in what is called the “water window.” This new method holds promise in making bioimaging X-ray machines smaller and more flexible to use.

Water-window X-rays are useful for bioimaging because they visualize biological cells at high contrast without staining them or requiring potentially damaging preparation.

However, some tabletop machines only produce radiation in a fixed range of energies, so more machines are needed if X-rays of varying energies are required to improve image contrast. Even then, they cannot cover the full spectrum of energies in the water window. There are single machines that can flexibly produce X-rays of different energies, but these are expensive synchrotrons larger than a house and difficult for most researchers to access.

Missing technosignatures? Turbulent plasma may blur ultra-narrow signals before they leave their home star systems

A new study by researchers at the SETI Institute suggests that stellar “space weather” could make radio signals from extraterrestrial intelligence harder to detect. Stellar activity and plasma turbulence near a transmitting planet can broaden an otherwise ultra-narrow signal, spreading its power across more frequencies and making it more difficult to detect in traditional narrowband searches. The paper is published in The Astrophysical Journal.

For decades, many SETI experiments have focused on identifying spikes in frequency—signals unlikely to be produced by natural astrophysical processes. But the new research highlights an overlooked complication: even if an extraterrestrial transmitter produces a perfectly narrow signal, it may not remain narrow by the time it leaves its home system.

In most technosignature searches, scientists account for distortions that happen as radio waves travel across interstellar space. This study focuses on what can happen closer to the source. Plasma density fluctuations in stellar winds, as well as occasional eruptive events such as coronal mass ejections, can distort radio waves near their point of origin, effectively “smearing” the signal’s frequency and reducing the peak strength that search pipelines rely on.

Scientists put forward a new theory of brain development

Your brain begins as a single cell. When all is said and done, it will house an incredibly complex and powerful network of some 170 billion cells. How does it organize itself along the way? Cold Spring Harbor Laboratory neuroscientists have come up with a surprisingly simple answer that could have far-reaching implications for biology and artificial intelligence.

Stan Kerstjens, a postdoc in Professor Anthony Zador’s lab, frames the question in terms of positional information. “The only thing a cell ‘sees’ is itself and its neighbors,” he explains. “But its fate depends on where it sits. A cell in the wrong place becomes the wrong thing, and the brain doesn’t develop right. So, every cell must solve two questions: Where am I? And who do I need to become?”

In a study published in Neuron, Kerstjens, Zador, and colleagues at Harvard University and ETH Zürich put forward a new theory for how the brain organizes itself during development.

How does a developing brain self-organize? Cell lineage may guide neuron placement

Your brain begins as a single cell. When all is said and done, it will house an incredibly complex and powerful network of some 170 billion cells. How does it organize itself along the way? Cold Spring Harbor Laboratory neuroscientists have come up with a surprisingly simple answer that could have far-reaching implications for biology and artificial intelligence.

Stan Kerstjens, a postdoc in Professor Anthony Zador’s lab, frames the question in terms of positional information. “The only thing a cell ‘sees’ is itself and its neighbors,” he explains. “But its fate depends on where it sits. A cell in the wrong place becomes the wrong thing, and the brain doesn’t develop right. So, every cell must solve two questions: Where am I? And who do I need to become?”

In a study published in Neuron, Kerstjens, Zador, and colleagues at Harvard University and ETH Zürich put forward a new theory for how the brain organizes itself during development.

Space Station Microbes Harvest Metals from Meteorites

Most microbes aboard the International Space Station can extract valuable metals like palladium from meteorite material in microgravity, showing potential for sustainable space resource mining.


How can microbes be used to help enhance human space exploration, specifically on the Moon and Mars? This is what a recent study published in npj Microgravity hopes to address as a team of scientists investigated how microbes could be used to harvest essential minerals from rocks that could be used to enhance sustainability efforts on long-term human missions to the Moon and Mars. This study has the potential to help scientists develop new methods for improving human spaceflight, which could substantially alleviate the need for relying on Earth for supplies.

For the study, the researchers sent meteorite and microorganism samples to the International Space Station (ISS) where astronauts conducted a series of experiments to ascertain how microorganisms could harvest essential minerals, specifically platinum and palladium, from the meteorite samples. Concurrently, the researchers also conducted the same experiments on Earth to compare the results under microgravity and terrestrial environments.

The goal of the study was to ascertain whether microorganisms could be used on future long-term space missions to harvest precious metals for construction of space habitats. In the end, the researchers and astronauts found that the microorganisms not only successfully extracted metals like palladium and platinum but also had minimal fungal residues typically that results from such processes. This lack of fungal residue was found to be more prevalent under microgravity conditions.

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