Dark events are organised events linked to death, disaster and suffering, and this conceptual study provides a new framework that can be used in their analysis. The framework has been developed through a theoretical synthesis of concepts from the domain theory of thanatology, and the method theories of dark tourism, dark leisure and collective memory. Six concepts of value for research into dark events are identified: commercialisation; approaches; public sphere; deviant behaviour; experiences; presence of death. The conceptual framework establishes a coherent conceptual footing for dark event research, and highlights links to established theories and methods that can be of value to future researchers in this novel area. Finally, we present an agenda for future research into dark events.

New research reveals that Flagstones in Dorset dates back to 3,200 BC, offering new insight into the origins of monumental architecture in the Neolithic period. Archaeological research at the prehistoric Dorset burial site known as Flagstones has identified it as the earliest known large circular

Noticing somebody fidgeting can be distracting. Vexing. Even excruciating. But why?

According to research, the stressful sensations caused by seeing others fidget are an incredibly common psychological phenomenon, affecting as many as one in three people.

Called misokinesia – meaning ‘hatred of movements’ – this strange phenomenon had been little studied by scientists until recent years, but was noted in the context of a related condition, misophonia: a disorder where people become irritated upon hearing certain repetitious sounds.

A Blog post by Ksenia Se on Hugging Face.

Rao et al. found that lactylation stimulates the proteasomal degradation of cGAS independent of ubiquitin, which is compromised by phosphorylation of PSMA4 via disrupting its association with cGAS. Lactylation rewires PIK3CB activity and impairs ULK1-driven phosphorylation of PSMA4. Consequently, lactylation of cGAS sustains tumor growth and indicates the prognosis of LUAD.

The classic definitions of bundle branch and fascicular block have been established without consideration if conduction block is complete or incomplete (conduction delay). Current electrocardiographic (ECG) definitions cannot distinguish pronounced conduction delay (first-degree block) from complete conduction block. We are presenting here 2 cases of first-degree left bundle branch block (LBBB) that may be relevant when interpreting findings and observations during conduction system pacing.

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA splicing. Two molecular control factors play a key role in splicing, the process by which precursor messenger RNA (pre-mRNA) is cut and reassembled into mature mRNA, a critical s