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In a new study, a Yale Pathology team has identified a possible therapeutic target for treating obesity-induced liver cancer.

Researchers say inhibiting a molecule called fatty acid binding protein 5 (FABP5) could block tumor progression in many cases:


Inhibiting a certain protein in mice reduced obesity-induced liver tumor development, Yale researchers found. It could reveal a future treatment route.

In this study, we leverage wavelet-based bispectral analysis of magnetic fluctuation data to identify likely candidates for nonlinear three-wave coupling, which are subsequently investigated with bandpass filtering. The participating waves, two TAEs and a low-frequency magnetohydrodynamic (MHD) mode, are seen to satisfy coupling conditions in both frequency and toroidal wavenumber, consistent with nonlinear generation. We conclude that the detection of quadratic nonlinearities on sub-millisecond time scales is possible with this technique.

The paper is organized as follows: Sec. II provides an overview of the relevant theory of TAE, while Sec. III contextualizes the experiment and describes its data. Section IV provides a primer on bicoherence analysis, in addition to simple examples of its implementation. Section V applies time-resolved bispectral analysis to the experimental data, focusing on the detection of quadratic nonlinearities. Section VI summarizes our work and considers the next steps of the analysis.

Meta’s move into the open social web, also known as the fediverse, is puzzling. Does the Facebook owner see open protocols as the future? Will it embrace the fediverse only to shut it down, shifting people back to its proprietary platforms and decimating startups building in the space? Will it bring its advertising empire to the fediverse, where today clients like Mastodon and others remain ad-free?

One possible answer can be teased out of a conversation between two Meta employees working on Threads and Flipboard CEO Mike McCue, whose company joined the fediverse with its support of ActivityPub, the protocol that powers Mastodon and others.

On McCue’s “Flipboard Dot Social” podcast, he spoke to two leaders building the Threads experience, director of product management Rachel Lambert and software engineer Peter Cottle. McCue raised questions and concerns shared by others working on fediverse projects, including what Meta’s involvement means for this space, and whether Meta would eventually abandon Threads and the fediverse, leaving a destroyed ecosystem in its wake.