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Adrenergic receptors (ARs) are preferentially expressed by innate lymphocytes such as natural killer (NK) cells.

Here, we study the effect of epinephrine-mediated stimulation of the β2-adrenergic receptor (β2AR) on the function of human NK cells.


β2-Adrenergic receptor stimulation inhibits NK cell activation. (A) β2-Adrenergic receptor expression analysis of PBMCs by flow cytometry (n = 8). Subsets were assigned according to the following markers: B cells (CD19+), NK cells (CD56+, CD3), CD56 dim (CD56dim, CD3), CD56 bright (CD56bright, CD3), NK-T cells (CD56+, CD3+), T cells (CD3+), and monocytes (FSC/SSC). (B) Representative β2-adrenergic receptor (β2AR) expression histograms of freshly isolated or cultured NK cells. © IFNγ secretion of fresh NK cells (top) or cultured NK cells (bottom). NK cells were pretreated with epinephrine ± propranolol (each 1 µM) and stimulated for 5 h by plate-bound antibodies as indicated. Supernatant was analyzed by IFNγ ELISA (mean, n = 3). (D) Degranulation of fresh NK cells (top) or cultured NK cells (bottom) was analyzed by CD107a expression. NK cells were pretreated and stimulated (3 h) like in ©, (mean, n = 3). Statistical analysis in © and (D) was performed using two-way ANOVA test, **** p < 0.0001; *** p < 0.001; ** p < 0.01; control set to 100%).

Their research is published in the Journal of Lightwave Technology.

“We tackled the persistent issue of balancing spatial resolution and measurement range in our original fiber-optic distributed strain sensing technique called BOCDR,” said Associate Professor Yosuke Mizuno of Yokohama National University. “Our purpose was to develop a more efficient system that overcomes this trade-off without relying on complex components like variable delay lines.”

The conventional BOCDR technique offers advantages such as operation with light injection from one end of the sensing fiber, relatively , and random-access capability to sensing points. However, it also faces trade-offs between spatial resolution and measurement range. Previous efforts to mitigate this issue have included special schemes, such as temporal gating, double modulation, and chirp modulation.

Researchers have recently observed a fascinating effect in the behavior of twisted light when it reflects off surfaces.


Everyday experience tells us that light reflected from a perfectly flat mirror will give us the correct image without any deformation. Interestingly, this is not the case when the light field itself is structured in a complex way. Tiny deformations appear.

Dr Shannon Curry said she believes humans will first land on Mars — at the earliest — in 2040, but more realistically 2050. And 2075 before Mars colonization! Very realistic prediction, and I enthusiastically agree.


NASA’s MAVEN spacecraft, led by scientists at the University of Colorado Boulder, was supposed to operate for one year when it entered orbit on September 21, 2014. Ten years later, the Mars Atmosphere and Volatile Evolution orbiter has been a boon to scientists studying the red planet and they hope it will remain in operation for years to come.

In May, MAVEN researchers got to watch as a huge solar storm hit the planet along with a massive dose of radiation. The MAVEN spacecraft is an orbiter, so it won’t ever land on the surface of Mars like the Curiosity and Perseverance rovers. Instead, it’s designed to examine the Martian atmosphere, which principal investigator Shannon Curry said “holds a number of secrets in terms of our past, present, and future.”

Here are some takeaways from Curry’s interview with Colorado Matters.