Satapathy et al. demonstrate that prostaglandin E2 promotes YAP-dependent nuclear translocation of PD-L1 via importin-α3. In the nucleus, PD-L1 cooperates with YAP-TEAD to enhance transcriptional activity, revealing a noncanonical role for PD-L1 in regulating oncogenic gene expression beyond immune evasion.
Category: futurism – Page 117
Incorporating Intensity Modulated Total Body Irradiation (IMRT-TBI) into Future Cooperative Group Clinical Trials: An NRG Hematologic Malignancies Working Group-Led Report from the National Clinical Trials Network
Read it in the RedJournal: @NRGOnc
: Intensity-modulated radiation therapy (IMRT) is increasingly used for total body irradiation (TBI) due to its ability to deliver myeloablative doses while sparing radiosensitive organs. To enable consistent evaluation in future National Clinical Trials Network (NCTN) studies, the xxx Hematologic Malignancies Working Group (HMWG) convened IMRT-TBI experts and NCTN leaders to develop consensus recommendations for standardized multi-institutional implementation.
Gravitational Collapse Primes Galactic Magnetism
A coordinate transformation devised for an expanding universe leads to new insights into how a collapsing protogalaxy acquires a large magnetic field.
Scientists Revive a 3.2-Billion-Year-Old Enzyme To Unlock Life’s Origins
A resurrected ancient enzyme is helping scientists test how reliably Earth’s oldest rocks record signs of life.
Cisco Confirms Active Exploitation of Two Catalyst SD-WAN Manager Vulnerabilities
Cisco warns CVE-2026–20122 and CVE-2026–20128 in Catalyst SD-WAN Manager are actively exploited; patches released across multiple software versions.
Why conversation is more like a dance than an exchange of words
Think about the last time you told a story to a friend. You probably adjusted it halfway through. You saw their eyebrows lift. You noticed them lean in, or glance away. You clarified a detail. You sped up the ending. That constant fine-tuning is not a bonus feature of communication: it is communication. And you can read all about this real-time coordination process in a new review by Judith Holler and Anna K. Kuhlen (Max Planck Institute for Psycholinguistics), published in Nature Reviews Psychology.
Holler and Kuhlen argue that conversation is not simply one person speaking while another listens. It is a process in which both participants continuously monitor, predict, and shape each other’s behavior. “Conversation is not a linear exchange of words,” Holler writes. “It is a jointly managed activity in which meaning emerges through coordination.”
‘Nano-origami’ reshapes liquid droplets into six-pointed stars
For the first time, researchers in France and Israel have observed how an emulsified liquid droplet can transform from a hexagon into a six-pointed star shape in response to rising temperature. Publishing their results in Physical Review Letters, a team led by Eli Sloutskin at Bar-Ilan University has shed new light on the mechanisms underlying this striking behavior, revealing a previously unseen form of “nano-origami,” that could inspire future generations of self-assembling nanostructures.
When tiny amounts of liquid are isolated, surface tension usually drives them to adopt a spherical shape—but over the past decade, researchers have uncovered far more complex behavior in emulsions of oil and water. In these systems, droplets are stabilized by surfactant molecules, which reduce the surface tension between the two liquids.
Under carefully controlled temperature changes, these droplets can undergo dramatic shape transformations. Previous studies have shown spheres turning into icosahedra, and then flattening into triangular, parallelogram or hexagonal, lens-like shapes with exclusively convex edges.
Unveiling hidden variables in stressed bacteria
Noise in bacterial stress responses is often dismissed as mere randomness. While true stochasticity exists, much variation reflects hidden variables—cell state, history, and microenvironment—that are only now becoming measurable. Choudhary and Vincent review emerging tools that disentangle chance from determinism, moving microbiology toward more mechanistic and predictive frameworks.
How some skills become second nature
Patterns of gaze and attention can reveal how some people unconsciously figure out how to master a task, MIT researchers have shown.
SNAP25 undergoes phase separation to facilitate the assembly of the synaptic vesicle fusion machinery
Zhu et al. find that SNAP25, a key SNARE protein involved in synaptic vesicle fusion, undergoes phase separation, which is regulated by palmitoylation modification and interaction with syntaxin-1. The SNAP25 condensates recruit syntaxin-1 and VAMP2 to form coacervates, facilitating vesicle docking and the assembly of the SNARE complex.